https://psychedelicslovershop.com

[flexgustavo (OP)]

Hey everyone,

I wanted to open up a discussion around 5-MeO-DMT—sometimes called the "God molecule"—and hear from folks who’ve worked with it, or are considering it. It seems to have a reputation that’s very different from other psychedelics, and I'd love to get some deeper insight from this community.

What is 5-MeO-DMT?

For those newer to it: 5-MeO-DMT is a powerful, naturally occurring tryptamine, found in certain plants, toads (Bufo alvarius), and also synthesized. It’s not the same as N,N-DMT—it’s often described as more non-dual, ego-dissolving, and less “visual,” though it varies a lot by person and dose.

A Few Questions I’m Exploring:

How would you describe the difference between 5-MeO-DMT and N,N-DMT (the “classic” DMT)?

What mindset and setting do you think are essential for working with this substance? I’ve read that it can be extremely destabilizing if not approached with care.

Plugging vs vaping vs insufflation – what are the major differences in onset, duration, and intensity?

Did it change anything for you? Spiritually, mentally, or emotionally? Temporary or lasting?

What I’ve Learned So Far (from reading, not personal experience yet):

It’s not recreational. People describe it as “dying before dying.”

Integration seems huge after an experience—people report bliss, but also confusion, emotional upheaval, or dissociation if not prepared.

There are risks, especially with dose titration. Going too hard can be traumatic or dangerous (there are stories of seizures, blackouts, or extreme panic).

Set, setting, and sitter are more important here than with maybe any other psychedelic.

If you've had experience with 5-MeO-DMT (synthetic or from toad), I’d love to hear:

How you prepared

What dosage you worked with

How you integrated the experience afterward

Any advice or red flags you’d offer to someone approaching this substance for the first time

Let’s keep this grounded in harm reduction, consent, and respect for the power of this compound. I'm not looking to source it, just trying to learn from those who’ve walked the path.

Thanks in advance for sharing your wisdom and stories.