Piperine + Dopamine Receptors

[smfadmin (OP)]

🧠 Dopamine & MA + Piperine / Hordenine Stack — Condensed Notes

1. Piperine + Dopamine Receptors 
💊 Piperine **does NOT directly increase dopamine receptor sensitivity** 
⚡ Main effect: **CYP3A4/CYP2D6 inhibition**, slows MA metabolism → higher, longer dopamine 
🧪 Mild **MAO inhibition** possible 
⚠️ High doses (200 mg+) → gut irritation, unpredictable effects 

2. Effects of MA + Piperine 
⏳ Slower onset, **sharper peak once absorbed** 
📈 **Extended plateau** → longer functional stimulation 
❌ Piperine increases exposure, **does not restore receptor sensitivity** 

3. Hordenine + MA + Piperine 
🌿 Hordenine: **NRI + mild TAAR1 activity**, additive with MA 
⏱ Piperine slows Hordenine clearance → stronger effect 
💥 Combined: higher norepinephrine + dopamine, longer duration, elevated HR/BP 
⚠️ Not a resensitizer — stresses desensitized receptors 

4. Timeline of Effects (150 mg MA + 200 mg Piperine + 450 mg Hordenine)

| Time        | Effect |
|------------|--------|
| 0–0.5 hr   | Mild alertness, delayed onset |
| 0.5–2 hr   | Rising phase; jitters, mild jaw tension |
| 2–6 hr     | Peak/plateau; functional stimulation, motivation, cardiovascular load |
| 6–12 hr    | Declining; wired tail, restlessness, appetite suppression, sleep disruption |
| 12–24 hr   | Comedown; fatigue, low mood, mental fog, gut irritation |

5. Dopamine Receptor Resensitization 
🔹 High MA tolerance → D1/D2 downregulation 
🔹 Recovery = **rest receptors, not more dopamine**

Recovery Protocol (60 × 1000 mg CDP-Choline) 

💊 Core Stack: 
- CDP-Choline: 250–500 mg AM with food/fat 
- Omega-3 (DHA/EPA): 1000–2000 mg/day 
- Magnesium glycinate/threonate: 200–400 mg PM 

🧩 Optional Builders: 
- Uridine Monophosphate: 150–250 mg AM 
- NAC: 600–1200 mg/day 
- B-vitamins: B6, B9, B12 

🏃 Lifestyle: 
- Exercise 3–5×/week → boosts D2 receptor density 
- Solid sleep → receptor density rebounds 
- Novelty/learning → natural dopamine stimulation 

⏱ Timeline: 
- 1–2 weeks → subtle clarity/focus 
- 1–2 months → reward sensitivity improves 
- 3+ months → motivation rebound 
- 3–6 months → major receptor recovery (if MA minimal) 

⚠️ MA Use During Recovery: 
- Low-dose or spaced out only 
- Micro-dosing occasionally okay, frequent use slows recovery 

6. CDP-Choline Notes 
- Supports **receptor density, synapse repair, membrane health** 
- Works best with **DHA + uridine** 
- Dose: 250–500 mg/day, split 1000 mg capsules 
- Benefits over **weeks–months** 
- Supply: 60 × 1000 mg → ~4 months at 500 mg/day 

7. Safety & Warnings 
- MA + Piperine + Hordenine → increased cardiovascular load; monitor HR/BP 
- Piperine prolongs clearance → longer effects 
- Gut irritation, restlessness, insomnia possible 
- Stack **does NOT resensitize receptors**; repeated use worsens tolerance 

8. TL;DR 
- ⚡ Piperine = metabolic amplifier, not receptor fixer 
- 🧠 CDP-Choline + DHA + uridine + magnesium + lifestyle = true receptor rebuilding 
- 🚀 MA/Hordenine/Piperine = functional boost, long tail, receptor stress 
- 🔑 Recovery = **time off stimulants + nutrition + exercise + sleep**