All Known Psychoactive Drug Categories and Examples of Interest

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📚 Psychoactive Drug Categories and Examples (Expanded)

🌿 Ethnobotanicals
- Ayahuasca — DMT + Harmine, Harmaline
- Ibogaine — Ibogaine
- Kava — Kavalactones
- Kratom — Mitragynine, 7-Hydroxymitragynine
- Salvia divinorum — Salvinorin A
- Peyote — Mescaline
- San Pedro Cactus — Mescaline
- Blue Lotus — Aporphine, Nuciferine
- Syrian Rue — Harmaline, Harmine (MAOIs)
- Yopo / Vilca — Bufotenin, 5-MeO-DMT
- Amanita muscaria — Muscimol, Ibotenic acid
- Calamus root — Beta-asarone
- Voacanga africana — Voacangine
- African Dream Root (Silene capensis) — Triterpenoid saponins
- Calea zacatechichi — Unknown bitter sesquiterpenes

🧠 Oneirogens (Dream Inducers)
- Calea zacatechichi — Dream herb
- Silene capensis — Xhosa dream root
- Galantamine — Acetylcholinesterase inhibitor
- Mugwort — Thujone, cineole
- Phenibut — β-Phenyl-GABA; GABA-B agonist with dream-enhancing properties

☠️ Deliriants (Anticholinergic Hallucinogens)
- Datura stramonium — Scopolamine, Atropine
- Brugmansia — Hyoscine
- Belladonna — Atropine, Scopolamine
- Diphenhydramine — H1 antagonist; anticholinergic in high doses
- Mandrake root — Scopolamine derivatives

💥 Designer Dopaminergics (Stimulant RCs)
- Prolintane — NDRI
- Ethylphenidate — Dopamine/NE reuptake inhibitor
- Isopropylphenidate — Longer acting analog
- Desoxypipradrol (2-DPMP) — Ultra-long acting stimulant

🧬 Peptides / Neuropeptides
- Semax — ACTH(4-10) analog, nootropic, anxiolytic
- Selank — Tuftsin analog, anxiolytic, immune-modulating
- DSIP — Delta sleep-inducing peptide
- Oxytocin — Social bonding, trust, cognition
- Vasopressin — Memory, aggression modulation

🧫 Immunopsychoactives (Inflammation-Modulating Psychoactives)
- LPS (Lipopolysaccharide) — Induces sickness behavior in animal models
- Infliximab — TNF-alpha blocker studied for depression
- IL-6 modulators — Linked to mood regulation in current research

🌬️ Inhalants and Volatile Agents
- Nitrous Oxide — NMDA antagonist
- Amyl Nitrite — Vasodilator, mild euphoria
- Butyl Nitrite — “Poppers”, similar to amyl
- Toluene — Solvent abuse (dangerous)
- Ether — Legacy anesthetic
- Chloroform — CNS depressant, toxic

🎨 Psychedelic Amphetamines (DOx / NBOMe Class)
- DOC — 4-chloro-2,5-dimethoxyamphetamine
- DOB — 4-bromo-2,5-dimethoxyamphetamine
- DOI — 4-iodo-2,5-dimethoxyamphetamine
- 25I-NBOMe — Extremely potent 5-HT2A agonist
- 25C-NBOMe — Chlorinated analog

🧪 Hormonal Modulators (Neuroendocrine-Linked Psychoactivity)
- Arimidex (Anastrozole) — Aromatase inhibitor
- Letrozole — Estrogen synthesis blocker
- Clomiphene — Estrogen receptor modulator
- Tamoxifen — SERM; sometimes nootropic-like effects