What happens when you take Zolpidem Tartrate ?
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Dear Health Professionals,
I want nothing except your consideration on this matter and you were recommended to me.
My background is in Large Systems and I'm running a few AI systems to verify my thoughts and now I defer to the trained.
* Phase 1:
A. Get a Lipidomic profile, if possible.
B. Check genetic markers for autoimmune disease.
C. Compound/Swallow:
1. L-Methionine 500-2000 mg
with
2. SAMe
with
3. Methyl B12
with
4. NAC 600-1200 mg
with
5. 1000 mg Ascorbic acid
with
6. Acetyl-CoA
D.Treat for 3 months
E. Repeat 0. for another Lipidomic profile ?
F. Compare with D. against B. and
G. Is there a satisfactory improvement ?
Yes - Keep treating
H. No - Check the genome's genetic markers for autoimmune disease / this disorder.
Intercept *Histone process* dor Epigenetic Gene Edit and start silencing/activating the most debilitating genetic markers with CRISPR/CAS9~CAS13.
Goal: Target specific gene expressions related to inflammation, neurodegeneration, or motor neuron function by modifying epigenetic markers.
Feasibility: Epigenetic editing with CRISPR/Cas technology is still in experimental stages for complex diseases like MND, particularly in neurons.
While it’s an exciting frontier, safety and specificity challenges remain, especially for conditions where multiple genes are involved.
This structured approach provides a mix of metabolic support, genetic assessment, and advanced therapeutic goals.
* Phase 2 - Consider one of more of the following therapies:
1. CDP-Choline
for synapse support.
2. L-Dopa
for Parkinson’s but may help here too.
3. Methylphenidate - 10 mg
standalone or to offset the Zolpidem "option of last resort".
4. Nicotine Gum - 4 mg
to activate the NMJ or Neuro Muscular Junction.
5. L-Glutamine and GABA supplement
* try to stabilise the 15 Transporters in the Glutaminergic-GABAergic complex.
6. ECT
may resynchronise the Irregular neural oscillations.
7. Check all Reflexes, confirm local signalling is functional.
8. Stem cell therapies could help.
9. Resveratrol
Voltage Gated Calcium channel promoter.
10. Pregabalin
Voltage Gated Calcium channel blocker and nerve agent.
11. For more symptom acquisition try to inject Botox at signal attenuation point and report your observations.
12. SSRIs have proven to promote nerve growth through it action as a potent neuroplastic agent.
13. NGF (Nerve Growth Factor) therapy.
14. 👉 ZOLPIDEM Tartrate with trace doses of Flumazenil to emulate a psuedo-partial agonist like the "Targin of Z-drugs."
Yours faithfully,
Andrew Egerszegi
Post Merged: December 17, 2024, 03:12:23 PM
Zolpidem, a sedative-hypnotic drug primarily used to treat insomnia, has shown some unexpected benefits in patients with neurological conditions, including aphasia. The relationship between aphasia and zolpidem is an area of growing interest, though research remains experimental and not yet conclusive.
How Zolpidem May Help with Aphasia
Zolpidem works by modulating GABA receptors in the brain, which are involved in inhibitory neurotransmission.
In some cases, especially post-stroke or brain injury, zolpidem has been reported to temporarily improve speech and cognitive function in individuals with aphasia.
Potential Mechanisms
1. Awakening Effects: Zolpidem may restore temporary neural activity in dormant or damaged brain areas (often called diaschisis).
2. Neuromodulation: By enhancing inhibitory pathways, zolpidem may help rebalance brain activity, improving language function.
Research and Case Reports
There have been isolated case studies where patients with non-fluent aphasia (e.g., Broca’s aphasia) experienced improved speech after taking low doses of zolpidem.
Some studies suggest this effect may occur in stroke patients with aphasia, where zolpidem awakens underperforming neural circuits.
Improvements are often temporary and occur within hours of taking the drug.
Caution and Limitations
1. Temporary Effects: Improvements, if any, are often short-lived and require further study.
2. Side Effects: Zolpidem can cause drowsiness, confusion, or dependency, making it risky for regular use without proper supervision.
3. Individual Variability: Not all patients respond positively, and the mechanisms are not fully understood.
Current Status
Zolpidem is not approved as a standard treatment for aphasia.
It remains an experimental option in clinical research and case-specific settings.
Conclusion
If considering zolpidem for aphasia, it is crucial to consult with a neurologist or a specialized physician. They can evaluate risks, monitor its effects, and determine if it may offer therapeutic benefits in your specific case.
Post Merged: December 17, 2024, 03:14:22 PM
If it works then we can add some Flumenazil to stop addiction or habitation.
Post Merged: December 17, 2024, 03:29:57 PM
Histamine H3 receptor (H3R) inverse agonists are being explored for their potential to treat various central nervous system (CNS) disorders, including cognitive impairments and motor deficits[43dcd9a7-70db-4a1f-b0ae-981daa162054](
https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1"). While there isn't specific research directly linking H3R inverse agonists to the treatment of aphasia, their impact on cognitive functions suggests they might have potential in this area as well[43dcd9a7-70db-4a1f-b0ae-981daa162054](
https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
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H3R inverse agonists block the H3 receptor, which is a negative regulator of histamine release in the brain[43dcd9a7-70db-4a1f-b0ae-981daa162054](
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2"). By inhibiting this receptor, these drugs can increase the release of histamine and other neurotransmitters like dopamine, which play a role in cognitive processes and motor functions[43dcd9a7-70db-4a1f-b0ae-981daa162054](
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").
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https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").
- **Attention-Deficit Hyperactivity Disorder (ADHD)**: Enhancing attention and reducing impulsivity[43dcd9a7-70db-4a1f-b0ae-981daa162054](
https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
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https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
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