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Author Topic: Aphasia  (Read 1385 times)

Offline Chip (OP)

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Aphasia
« on: December 17, 2024, 12:00:51 PM »
What happens when you take Zolpidem Tartrate ?

To: info@mndaustralia.org.au,
info@mndnsw.asn.au,
info@mndvic.org.au,
info@mndqld.org.au,
info@mndresearch.org.au,
info@mndcare.org.au,
info@naa.org.au,
info@aihw.gov.au,
mndresearch@unimelb.edu.au,
neuroscience.research@sydney.edu.au,
enquiries@florey.edu.au,
aegersz@gmail.com

Dear Health Professionals,

I want nothing except your consideration on this matter and you were recommended to me.

My background is in Large Systems and I'm running a few AI systems to verify my thoughts and now I defer to the trained.

* Phase 1:

A. Get a Lipidomic profile, if possible.

B. Check genetic markers for autoimmune disease.

C. Compound/Swallow:

1. L-Methionine 500-2000 mg
with
2. SAMe
with
3. Methyl B12
with
4. NAC 600-1200 mg
with
5. 1000 mg Ascorbic acid
with
6. Acetyl-CoA

D.Treat for 3 months

E. Repeat 0. for another Lipidomic profile ?

F. Compare with D. against B. and

G. Is there a satisfactory improvement ?

Yes - Keep treating

H. No - Check the genome's genetic markers for autoimmune disease / this disorder.

Intercept *Histone process* dor Epigenetic Gene Edit and start silencing/activating the most debilitating genetic markers with CRISPR/CAS9~CAS13.

Goal: Target specific gene expressions related to inflammation, neurodegeneration, or motor neuron function by modifying epigenetic markers.

Feasibility: Epigenetic editing with CRISPR/Cas technology is still in experimental stages for complex diseases like MND, particularly in neurons.

While it’s an exciting frontier, safety and specificity challenges remain, especially for conditions where multiple genes are involved.

This structured approach provides a mix of metabolic support, genetic assessment, and advanced therapeutic goals.

* Phase 2 - Consider one of more of the following therapies:

1. CDP-Choline
for synapse support.

2. L-Dopa
for Parkinson’s but may help here too.

3. Methylphenidate - 10 mg
standalone or to offset the Zolpidem "option of last resort".

4. Nicotine Gum - 4 mg
to activate the NMJ or Neuro Muscular Junction.

5. L-Glutamine and GABA supplement
* try to stabilise the 15 Transporters in the Glutaminergic-GABAergic complex.

6. ECT
may resynchronise the Irregular neural oscillations.

7. Check all Reflexes, confirm local signalling is functional.

8. Stem cell therapies could help.

9. Resveratrol
Voltage Gated Calcium channel promoter.

10. Pregabalin
Voltage Gated Calcium channel blocker and nerve agent.

11. For more symptom acquisition try to inject Botox at signal attenuation point and report your observations.

12. SSRIs have proven to promote nerve growth through it action as a potent neuroplastic agent.

13. NGF (Nerve Growth Factor) therapy.

14. 👉 ZOLPIDEM Tartrate with trace doses of Flumazenil to emulate a psuedo-partial agonist like the "Targin of Z-drugs."

Yours faithfully,

Andrew Egerszegi

Post Merged: December 17, 2024, 03:12:23 PM
Zolpidem, a sedative-hypnotic drug primarily used to treat insomnia, has shown some unexpected benefits in patients with neurological conditions, including aphasia. The relationship between aphasia and zolpidem is an area of growing interest, though research remains experimental and not yet conclusive.

How Zolpidem May Help with Aphasia

Zolpidem works by modulating GABA receptors in the brain, which are involved in inhibitory neurotransmission.

In some cases, especially post-stroke or brain injury, zolpidem has been reported to temporarily improve speech and cognitive function in individuals with aphasia.


Potential Mechanisms

1. Awakening Effects: Zolpidem may restore temporary neural activity in dormant or damaged brain areas (often called diaschisis).


2. Neuromodulation: By enhancing inhibitory pathways, zolpidem may help rebalance brain activity, improving language function.



Research and Case Reports

There have been isolated case studies where patients with non-fluent aphasia (e.g., Broca’s aphasia) experienced improved speech after taking low doses of zolpidem.

Some studies suggest this effect may occur in stroke patients with aphasia, where zolpidem awakens underperforming neural circuits.

Improvements are often temporary and occur within hours of taking the drug.


Caution and Limitations

1. Temporary Effects: Improvements, if any, are often short-lived and require further study.


2. Side Effects: Zolpidem can cause drowsiness, confusion, or dependency, making it risky for regular use without proper supervision.


3. Individual Variability: Not all patients respond positively, and the mechanisms are not fully understood.



Current Status

Zolpidem is not approved as a standard treatment for aphasia.

It remains an experimental option in clinical research and case-specific settings.


Conclusion

If considering zolpidem for aphasia, it is crucial to consult with a neurologist or a specialized physician. They can evaluate risks, monitor its effects, and determine if it may offer therapeutic benefits in your specific case.



Post Merged: December 17, 2024, 03:14:22 PM
If it works then we can add some Flumenazil to stop addiction or habitation.

Post Merged: December 17, 2024, 03:29:57 PM
Histamine H3 receptor (H3R) inverse agonists are being explored for their potential to treat various central nervous system (CNS) disorders, including cognitive impairments and motor deficits[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1"). While there isn't specific research directly linking H3R inverse agonists to the treatment of aphasia, their impact on cognitive functions suggests they might have potential in this area as well[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").

### **How H3R Inverse Agonists Work**
H3R inverse agonists block the H3 receptor, which is a negative regulator of histamine release in the brain[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2"). By inhibiting this receptor, these drugs can increase the release of histamine and other neurotransmitters like dopamine, which play a role in cognitive processes and motor functions[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").

### **Applications in CNS Disorders**
Research has shown that H3R inverse agonists have potential in treating various CNS disorders, such as:
- **Alzheimer's Disease**: Improving memory and cognitive functions[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").
- **Attention-Deficit Hyperactivity Disorder (ADHD)**: Enhancing attention and reducing impulsivity[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
- **Schizophrenia**: Addressing cognitive deficits and motor impairments[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2012.00072/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
- **Depression**: Improving mood and motivation[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.861094/full?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").

### **Potential for Aphasia**
While there isn't direct research on H3R inverse agonists for aphasia, their ability to enhance cognitive functions and neurotransmitter release suggests they could potentially benefit individuals with aphasia by improving language and communication skills.
« Last Edit: December 17, 2024, 03:29:57 PM by Chip »
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Offline Chip (OP)

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Re: Aphasia
« Reply #1 on: December 19, 2024, 09:25:13 AM »
To support robust myelination, it's important to include certain nutrients in your diet. Here are some key foods and supplements that can help:

### Foods:
1. **Fatty Fish**: Rich in omega-3 fatty acids, especially DHA (docosahexaenoic acid), which is crucial for myelin production[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.optimaldx.com/research-blog/nutrition-myelin-and-nervous-system-health?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
2. **Eggs**: Contain choline, which is essential for the synthesis of myelin[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.optimaldx.com/research-blog/nutrition-myelin-and-nervous-system-health?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
3. **Leafy Greens**: High in B vitamins, particularly B12 and folate, which support nerve health and myelination[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.optimaldx.com/research-blog/nutrition-myelin-and-nervous-system-health?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
4. **Nuts and Seeds**: Provide vitamin E and other nutrients that support brain health.
5. **Whole Grains**: Contain B vitamins and other nutrients that are important for nerve function.
6. **Lean Meats**: Provide iron and zinc, which are important for myelin production[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://selfhacked.com/blog/myelin/?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").

### Supplements:
1. **Omega-3 Supplements**: Fish oil supplements can provide DHA and EPA (eicosapentaenoic acid)[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.optimaldx.com/research-blog/nutrition-myelin-and-nervous-system-health?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
2. **Choline Supplements**: Can help support myelin synthesis[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.optimaldx.com/research-blog/nutrition-myelin-and-nervous-system-health?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
3. **B Vitamins**: Particularly B12 and folate supplements can be beneficial[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.optimaldx.com/research-blog/nutrition-myelin-and-nervous-system-health?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1").
4. **Vitamin E**: Supports overall brain health and may aid in myelin maintenance.
5. **Iron and Zinc Supplements**: Can help if you have deficiencies that affect myelin production[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://selfhacked.com/blog/myelin/?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").

It's always a good idea to consult with a healthcare provider before starting any new supplement regimen to ensure it's appropriate for your individual needs.

Do you have any specific dietary preferences or restrictions that I should consider when suggesting foods?

I'm taking your recommendations and applying them to aphasia from ischemic stroke.

That's a thoughtful approach! Aphasia resulting from an ischemic stroke can be challenging, but incorporating nutrients that support myelination might indeed be beneficial. Alongside dietary adjustments, speech and language therapy (SLT) is the primary treatment for aphasia[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://medshun.com/article/can-stroke-aphasia-be-cured?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1"). SLT helps improve communication abilities by using current language skills, restoring lost abilities, and finding alternative ways to communicate[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.stroke.org/en/about-stroke/effects-of-stroke/communication-and-aphasia/stroke-and-aphasia/aphasia-diagnosis-and-treatment?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2").

Would you like more information on specific therapies or exercises that can help with aphasia recovery?

Yes pls

Great! Here are some effective therapies and exercises for aphasia recovery:

### Speech and Language Therapy (SLT)
SLT is the primary treatment for aphasia and involves working with a speech-language pathologist to improve language skills[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://bing.com/search?q=aphasia+recovery+therapies&citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "1"). Techniques include:
- **Word Recall Exercises**: Practicing naming objects, people, and actions.
- **Communication Tactics**: Using gestures, drawing, or writing to communicate.
- **Repetition**: Repeating words and sentences to improve speech fluency.

### Constraint-Induced Language Therapy (CILT)
This therapy encourages the use of verbal language by restricting other forms of communication, such as gestures[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://neurolaunch.com/aphasia-therapy/?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2"). It's designed to improve language skills by forcing the brain to find new ways to communicate.

### Melodic Intonation Therapy (MIT)
MIT uses the musical elements of speech, such as melody and rhythm, to help patients with severe aphasia improve their ability to produce speech[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://neurolaunch.com/aphasia-therapy/?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "2"). It's particularly useful for those with non-fluent aphasia.

### Group Therapy
Participating in group therapy sessions can provide social support and opportunities to practice communication skills in a safe and supportive environment[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.medicalnewstoday.com/articles/is-aphasia-permanent?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "3").

### Technology-Assisted Therapy
Using apps and devices designed for aphasia therapy can provide additional practice and support outside of formal therapy sessions[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.medicalnewstoday.com/articles/is-aphasia-permanent?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "3"). These tools often include exercises for word retrieval, sentence construction, and comprehension.

### Supportive Environment
Creating a supportive environment at home and in social settings is crucial. This includes:
- **Short Sentences**: Using simple, clear sentences when communicating.
- **Patience**: Allowing extra time for the person with aphasia to respond.
- **Inclusion**: Encouraging participation in conversations and activities.

### Additional Resources
- **Mayo Clinic**: Offers comprehensive information on aphasia diagnosis and treatment[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.mayoclinic.org/diseases-conditions/aphasia/diagnosis-treatment/drc-20369523?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "4").
- **La Trobe University's Centre for Research Excellence in Aphasia Recovery and Rehabilitation**: Provides resources and research on aphasia recovery[43dcd9a7-70db-4a1f-b0ae-981daa162054](https://www.latrobe.edu.au/research/centres/health/aphasia?citationMarker=43dcd9a7-70db-4a1f-b0ae-981daa162054 "5").

 

Post Merged: December 19, 2024, 09:28:47 AM
@joshua updates for you
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