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Author Topic: Equivalent Benzodiazepine Calculator Calculates equipotent benzodiazepine doses  (Read 2373 times)

Offline Chip (OP)

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see https://globalrph.com/medcalcs/benzodiazepine-converter-dosage-conversions/

as https://clincalc.com/Benzodiazepine/ sems a little inaccurate.

BENZODIAZEPINE EQUIVALENT DOSAGE CONVERTER

Mechanism of Action - Benzodiazepines

Binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites within the central nervous system, including the limbic system, reticular formation. Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to chloride ions. This shift in chloride ions results in hyperpolarization (a less excitable state) and stabilization.

Hepatic disease: Depending on the agent, dosage reductions of 50% are required in mild to moderate impairment  and most agents should be avoided in severe/acute liver disease.  Refer to the specific package insert in all cases.

It is nearly impossible to determine an exact equivalent dose.  Differences in pharmacokinetic parameters between benzodiazepines can be quite profound.  Also researchers have not consistently identified equivalent dosages  between these agents (wide range of equivalent dosages reported).  Using a range of +/- 25% for the result above would produce the following equivalent dosage range:  Diazepam (22.5 - 37.5) mg

The actual equivalent dosage could be at the lower or upper end of this range.

The results above also do not take into account the maximum recommended daily dose. General dosing guidelines are listed below including the maximum recommended dose in a 24 hour period.
,

DIAZEPAM (VALIUM):

Dosing (Adults):  Anxiety/sedation/skeletal muscle relaxant:

Oral: 2-10 mg 2-4 times/day

I.M., I.V.: 2-10 mg, may repeat in 3-4 hours if needed.  Sedation in the ICU patient: I.V.: 0.03 to 0.1 mg/kg every 30 minutes to 6 hours. 

Status epilepticus: I.V.: 5-10 mg every 10-20 minutes, up to 30 mg in an 8-hour period; may repeat in 2-4 hours if necessary. Rapid tranquilization of agitated patient (administer every 30-60 minutes): Oral: 5-10 mg; average total dose for tranquilization: 20-60 mg.
Pharmacokinetics:  Long-acting.  Peak level (oral):  1-2 hours.  Average half-life (variable): 100 hours

Maximum dose/24hr: ~40 mg
« Last Edit: October 20, 2019, 05:16:16 PM by Chip »
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I do not condone or support any illegal activities. All information is for theoretical discussion and wonder.
All activities discussed are considered fictional and hypothetical. Information of all discussion has been derived from online research and in the spirit of personal Freedom.

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