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Author Topic: Equivalent Benzodiazepine Calculator Calculates Equipotent Benzodiazepine Doses  (Read 5234 times)

Offline Chip (OP)

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see https://globalrph.com/medcalcs/benzodiazepine-converter-dosage-conversions

or the Benzodiazepine Conversion Calculator (last updated: Feb 26, 2021).

as https://clincalc.com/Benzodiazepine/ seems a little inaccurate.

BENZODIAZEPINE EQUIVALENT DOSAGE CONVERTER

Mechanism of Action - Benzodiazepines

Binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites within the central nervous system, including the limbic system, reticular formation. Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to chloride ions. This shift in chloride ions results in hyperpolarization (a less excitable state) and stabilization.

Hepatic disease: Depending on the agent, dosage reductions of 50% are required in mild to moderate impairment  and most agents should be avoided in severe/acute liver disease.  Refer to the specific package insert in all cases.

It is nearly impossible to determine an exact equivalent dose.  Differences in pharmacokinetic parameters between benzodiazepines can be quite profound.  Also researchers have not consistently identified equivalent dosages  between these agents (wide range of equivalent dosages reported).  Use a range of +/- 25% for the results.

The actual equivalent dosage could be at the lower or upper end of this range.

The results above also do not take into account the maximum recommended daily dose. General dosing guidelines are listed below including the maximum recommended dose in a 24 hour period.
« Last Edit: March 20, 2024, 10:37:24 PM by Chip »
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