DMT is fun and apparently good for your perception of the world.
https://neurosciencenews.com/psychedelic-depression-9488/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+neuroscience-rss-feeds-neuroscience-news+%28Neuroscience+News+Updates%29
I can't speak to ayuascha, which is typically an experience led by a shaman and I've never had the inclination to do it without a shaman guide. I have, however, smoked very large amounts of deems. I can't say with any certainty that it was the cause, but smoking it very very frequently ended up with me experiencing ridicilous mood swings and sudden onsets of depression that resolved themselves as quickly as they came on. It's possible that molly was partly responsible for it, as I abused it way way way too much from 16-26 and I've almost totally lost the magic. Around the time I was frequently smoking deems, I was doing molly every few months (I only ever tested it with marquis and mecke reagant's so I can't say for sure what it was, but I'd guess it was MDA not MDMA since a friend of mine has tested molly over and over and over with Simons and has said that 90% of the stuff he tests is MDA) Moderation is obviously key with anything, especially strong mind altering substances.
With all that said, between my use of LSD over the last 2 years and my DMT use, I have an entirely different outlook on life that has completely changed since I was using. I appreciate the little things much more and I am more conscious of things I do of a selfish nature.