dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse

This website has run out of funding so feel free to contribute if you can afford it (see footer)

Author Topic: Methamphetamine induces DNA damage in specific regions of the female rat brain.  (Read 1847 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6493
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:August 01, 2021, 05:48:14 PM
  • Deeply Confused Learner
  • Profession: IT Engineer
shamelessly ripped straight from PubMed (is that like club med ?)

Methamphetamine is neurotixic and thus increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain.

They examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions.

Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine-rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine-rich brain regions that were tested.

Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.
well, that's me fucked and glad to not have wanted kids
I do not condone or support any illegal activities. All information is for theoretical discussion and wonder.
All activities discussed are considered fictional and hypothetical. Information of all discussion has been derived from online research and in the spirit of personal Freedom.

Tags:
 

Related Topics

  Subject / Started by Replies Last post
1 Replies
2916 Views
Last post August 09, 2015, 12:18:28 PM
by Narkotikon
6 Replies
5074 Views
Last post July 03, 2016, 10:10:42 PM
by Chip
22 Replies
8411 Views
Last post November 16, 2016, 12:38:05 PM
by Wildcat
0 Replies
1310 Views
Last post May 04, 2018, 12:30:01 PM
by Chip
2 Replies
2541 Views
Last post July 19, 2018, 03:59:01 AM
by neighborboy
0 Replies
1510 Views
Last post December 16, 2018, 07:18:39 PM
by Chip
0 Replies
1182 Views
Last post May 18, 2019, 07:53:52 AM
by Chip
0 Replies
2578 Views
Last post September 28, 2019, 05:44:36 AM
by Chip
0 Replies
407 Views
Last post June 08, 2021, 05:01:46 AM
by Chip
0 Replies
102 Views
Last post July 20, 2021, 05:15:08 PM
by Chip


dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse





TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE


Founded December 2014
SimplePortal 2.3.6 © 2008-2014, SimplePortal