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Author Topic: Bioavailability and pharmacokinetics of lorazepam after intranasal, etc.  (Read 3665 times)

Offline Jega (OP)

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http://www.ncbi.nlm.nih.gov/pubmed/11697755

Abstract
The purpose of this study was to evaluate the pharmacokinetic profile of intranasal lorazepam in comparison to currently established administration routes. Eleven healthy volunteers completed this randomized crossover study. On three occasions, each separated by a 1-week washout, subjects received a 2 mg dose of lorazepam via the intranasal, intravenous, or intramuscular route. Blood samples were collected serially from 0 to 36 hours. Noncompartmental methods were used to determine pharmacokinetic parameters. Lorazepam was well absorbed following intranasal administration with a mean (%CV) bioavailability of 77.7(11.1). Intranasal administration resulted in a faster absorption rate than intramuscular administration. Elimination profiles were comparable between all three routes. The concentration-time profile for intranasal delivery demonstrated evidence of a double peak in several subjects, suggesting partial oral absorption. Females were found to have significantly higher AUC values than males for all three delivery routes. Overall, this study demonstrated favorable pharmacokinetics of intranasal lorazepam in relation to standard administration methods. Intranasal delivery could provide an alternative, noninvasive delivery route for lorazepam.
PMID: 11697755 [PubMed - indexed for MEDLINE]

77 fucking percent! That beats oral! And if there is still partial oral absorption oh well, i'm swallowing them anyway. Wheres my mortar and pestle!?!?

Offline Narkotikon

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Re: Bioavailability and pharmacokinetics of lorazepam after intranasal, etc.
« Reply #1 on: September 24, 2015, 11:01:16 AM »
Have you ever gotten closed-eye visuals taking high-dose (10+ mg) Ativan / lorazepam? 
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Offline Anti-hero

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Re: Bioavailability and pharmacokinetics of lorazepam after intranasal, etc.
« Reply #2 on: September 24, 2015, 11:24:44 AM »
This really isn't that surprising
Because of the fact that atavan
Is the only one of the big four
That's water soluble
HeAd will snort any benzo

I don't find much if I snort the other three
I like putting them under my toung.
Have a real found taste for kpins
Scared to death
No reason why
Do one another
To get me by
Think about the things I said
Read the page it's cold and dead

Offline Jega (OP)

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Re: Bioavailability and pharmacokinetics of lorazepam after intranasal, etc.
« Reply #3 on: September 24, 2015, 11:34:51 AM »
This really isn't that surprising
Because of the fact that atavan
Is the only one of the big four
That's water soluble
Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. It is soluble in polyethylene glycol and probably benzyl alcohol. But if you can show me proof to the contrary i'd love love to see it! Really!
Have you ever gotten closed-eye visuals taking high-dose (10+ mg) Ativan / lorazepam?
I usually don't remember much after 10mg. I'm at 5 right now but 10 would probably throw me over the limit.
I'm still "panackie" but it's been a hard day.
Who knows todays a bad day, and I don't want to take a sixth of my supply in one day but fuck, I'm at my limit today and well medicated.

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