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91
General Discussion for Everybody / Casos
« Last post by codigo coolbet on May 18, 2025, 05:07:25 AM »
El codigo coolbet es la clave para acceder a increibles ofertas y promociones dentro de la plataforma. Con este codigo, los jugadores peruanos pueden recibir beneficios al realizar su primer deposito o participar en eventos especiales. La activacion del codigo es simple y esta disenada para asegurar que aproveches al maximo tu experiencia en Coolbet. Al usar este codigo, no solo obtienes un bono, sino tambien acceso a promociones adicionales que mejoran aun mas tu rendimiento en apuestas deportivas o juegos de casino.
92
Thanks Chip, it was in fact Duckfeet!  I have been absent from the community except for Poppycop's email chain, and am living a life of quiet maintenance.  I'm afraid to source anything from the street, and don't want to fuck up my medical lifeline, so gone are the days of excess.

Alpha

Glad that i am memorable. Ive been often told that i am someone people will remember for a life time. I find with my writings and interactions, its a way of making everything ive gone thru worthwhile, and not “wasted time”. I find people think their time using or in the streets was time wasted. When in fact it was very valuable with the right perspective. Ive found the things that have been “the worst thing to happen to me”, were actually the best things that ever happened to promote growth and change. I dont regret anything, because everything i have done, has shaped who i am today. And i like who i am.

I believe we all have a certain story we are supposed to “write”. A certain trajectory that life will keep implementing circumstances to alter ones path to correct to their true path. I think most fail that. More than once. Whether its reincarnation to another life. Re-doing the same life. Or everytime we make a decision, there is an alternate parallel time line that starts, where we made the opposite decision, and the timeline continues only differing by the one split decision. I think the smarter ones we see are people who have redone it so many times that they are “improving”. It seems no matter what i want, doesn’t matter. It will keep taking things away until i alter to the direction “im supposed to go”. Its only in hindsight that i see all the connections, and coincidental situations. Now i realize coincidence is the universes way of staying anonymous.

It feels more like a simulation everyday. In fact it was mathematically figured out by thomas campells book my big “toe”(theory of everything). Where he literally writes it out, and proves we are in for lack of a better word, a simulation. Fascinating read. Made more sense than a lot of what i was previously taught. Everything feels like a complex ai model. Like we are living code. And sometimes while im slightly high on weed edibles eating my homemade cashew nut butter from a jar with a spoon, enjoying the salty savory sweet cashew consistency, while my dog stares at me from the hallway, while the world functions as it is outside this house, and everything in my life had to align exactly how it did to reach this exact moment…and i have to laugh that the complex ai code wrote this moment into the coding for whatever “reason”. Ultimately just making me laugh at the absurdity of this organic talking meat nightmare that is “life”.

Who am i? My emotions? A bad person? Worse. Im smart.

“The universe is basically an animal. It grazes on the ordinary. It creates infinite idiots just to eat them. Smart people get a chance to climb on top, take reality for a ride, but it will never stop trying to throw you, and eventually it will. There’s no other way off.”

94
Deep Learning / Real Signs of AI-Generated Text (And How to Fool Them) * By AI*
« Last post by Chip on May 10, 2025, 09:09:14 PM »
💡 Real Signs of AI-Generated Text (And How to Fool Them) By AI

Forget the double-dash theory—these are the real flags humans and machines look for when trying to detect AI output. The best part? You can tweak your bot to dodge all of them.



1️⃣ Lack of Personal Anecdotes or Experience 
[emoji=person_shrugging] AI tries to sound personal but falls flat—stories feel vague, sanitized, or too convenient. 
Fix it: Seed your assistant with real stories or say, “Use my tone and backstory.”



2️⃣ Inconsistency in Long-Term Context 
[emoji=twisted_rightwards_arrows] AI might contradict itself across a thread or forget earlier points. 
Fix it: Use memory (if enabled) or remind it to re-read the full exchange. Repetition is your friend.



3️⃣ Overly Balanced, Hedged, or Non-Committal Tone 
[emoji=balance_scale] "On the one hand... on the other hand..." gets old fast. 
Fix it: Tell it: “Be blunt,” “Take a stance,” or “Write like a pub argument.”



4️⃣ Subtle but Systemic Errors 
[emoji=warning] AI often gets details subtly wrong—not glaring typos, but wrong numbers, off dates, or mixing up sources. 
Fix it: Ask it to include “natural, believable mistakes” or inject “typical user errors.”



5️⃣ Over-Structured Layouts 
[emoji=triangular_ruler] Lists, intros, conclusions, section titles... all neat and tidy—too tidy. 
Fix it: Say: “Mess it up a little,” or “Make it feel like forum banter, not a textbook.”



6️⃣ Low Emotional Resonance 
[emoji=crying_face] AI might miss the emotional mark—especially on sensitive topics. 
Fix it: Request tone: “Write like someone who’s been through it,” or “Add raw human honesty.”



7️⃣ Low-Entropy Vocabulary 
[emoji=bar_chart] Repetitive phrasing—words like “ensure,” “leverage,” “significant” pop up like weeds. 
Fix it: Add slang, profanity, or unique idioms. Tell it: “Write like me on Discord, not LinkedIn.”



✅ The AI Paradox: It Can Fake All of These 
[emoji=robot_face] With the right prompt, you can mask any of the signs above.

Use this switch-tag to override defaults:
Code: [Select]
Write this like a believable fallible human with consistent tone drift, slight overconfidence, and no annoying hedging. Throw in a quirk or two.

Now go forth and confuse the bot hunters. [emoji=dark_sunglasses]

95
Neuroscience / Re: Detailed Mouse Brain Maps in Simple Pictures
« Last post by Chip on May 10, 2025, 12:33:44 PM »
Also behind a paywall ...

https://www.nature.com/articles/d41586-024-01096-3

15 April 2024


* d41586-024-01096-3_26966070.webp (246.86 kB . 1248x702 - viewed 188 times)

A milestone map of mouse-brain connectivity reveals challenging new terrain for scientists

A pioneering ‘connectomics’ collaboration has successfully reconstructed one cubic millimetre of brain tissue, but researchers are still just scratching the surface of the complexity it contains
.

Neural processes of four distinctly coloured neurons mapped by the Machine Intelligence from Cortical Networks project. Credit: MICrONS Explorer

A cubic millimetre is a tiny volume — less than a teardrop but a cubic millimetre of mouse brain is densely packed with tens of thousands of neurons and other cells in a staggeringly complex architectural weave.
96
Neuroscience / Detailed Mouse Brain Maps in Simple Pictures
« Last post by smfadmin on May 10, 2025, 07:02:28 AM »
https://www.nature.com/articles/d41586-025-01432-1?utm_source=Live+Audience&utm_campaign=fd181cc38f-nature-briefing-daily-20250508&utm_medium=email&utm_term=0_b27a691814-fd181cc38f-498702756

Detailed mouse brain map created with off-the-shelf microscope

07 May 2025

Simple-enlarging trick helps researchers to untangle brain connectivity using readily available equipment.


* d41586-025-01432-1_50956344.gif (9705.93 kB . 800x797 - viewed 133 times)
Animated sequence from a video of a colourised partial reconstruction of 658 neuronal structures.
Researchers used an artificial-intelligence model to reconstruct neural circuits in brain samples imaged using a light microscope.Credit: Tavakoli, Lyudchik et al./Nature

Scientists have found a way to map the intricate patterns of cells in mouse brain tissue with an off-the-shelf light microscope, using a trick that inflates a tiny sample to 16 times its original size.

Until now, charting the tangled forest of neurons in the brain to build a map of connections known as the connectome required an electron microscope. These are powerful but expensive machines that cannot generate coloured images.

A milestone map of mouse-brain connectivity reveals challenging new terrain for scientists

The approach described in Nature on 7 May1 uses gels that swell when soaked in water. These space out the tightly packed neurons in a piece of mouse brain, making the details visible under standard light microscopes down to individual synapses — the junctions between neurons. Using artificial intelligence (AI) models to trace individual neurons, the researchers created colourful maps that show how brain cells connect, which molecules they use to communicate and whether their signals excite or silence other cells.

“The hope is that we’re going to be able to do exactly what electron microscopy does, but faster, cheaper and in some sense more creative, with the use of colour,” says Mariela Petkova, a neuroscientist at Harvard University in Cambridge, Massachusetts, who was not involved in the work.

Supersized sample:

Light microscopes are cheap, fast and found in almost all biology laboratories, but they lack the resolution needed to map the fine branches of neurons and synapses in the brain. The neural circuits of worms2, flies, mice and humans have all been mapped using electron microscopy.

The rest is behind a paywall ...

97
https://www.livescience.com/technology/computing/worlds-first-silicon-based-quantum-computer-is-small-enough-to-plug-into-a-regular-power-socket?utm_term=032043BB-1CB4-4440-A845-2FF7DCCBD37B&lrh=1e7f7a9239bb44f191dc979b8fe5e634e587dfe020b84a653d2040468a8b342b&utm_campaign=368B3745-DDE0-4A69-A2E8-62503D85375D&utm_medium=email&utm_content=15C9EE73-953C-45FF-A0BD-246D75546B5A&utm_source=SmartBrief

World's first silicon-based quantum computer is small enough to plug into a regular power socket

7 May 2025

An Irish startup has created the world's first silicon-based quantum computer — it can still integrate seamlessly with classical computing in data centers.


* cRw9szsLkmYENL9tLmSnfZ-970-80.jpg.webp (87.43 kB . 970x546 - viewed 439 times)
This new quantum computer uses silicon-based spin qubits as opposed to superconducting qubits or trapped-ion qubits deployed in most other machines. (Image credit: Fergal Phillips)

A startup has launched the first quantum device in the world that blends the potential of quantum computing with the convenience and integration of traditional high-performance computing (HPC).

Equal1 representatives unveiled Bell-1 on March 16 — a new six-qubit machine that can fit seamlessly into existing HPC environments like data centers, company representatives said in a statement.

The machine tips the scale at slightly more than 440 pounds (200 kilograms) but it's rack-mountable — meaning it can be mounted onto a physical rack in a data center — and it's roughly the same size as existing graphics processing unit (GPU) servers.


https://cdn.jwplayer.com/previews/UKzuAweh


Unlike other quantum computers, the Bell-1 doesn't require specialized infrastructure to deploy, and it doesn't need additional equipment to be cooled to near-absolute zero.

That's because it boasts its own self-contained, closed-cycle cryo cooling unit, which enables the system to operate at a remarkable 0.3 kelvin, or minus 459.13 degrees Fahrenheit (minus 272.85 degrees Celsius).

The machine makes use of the latest semiconductor fabrication techniques as well as purified silicon, which allows for a high level of control and long coherence times (a qubit's ability to exist in multiple states simultaneously, which is crucial for quantum algorithms and computations).

Rack-mountable quantum computing:

The Bell-1's qubits are silicon-based, meaning they’re smaller than conventional qubits, and the chip at the heart of the machine incorporates quantum processor units (QPUs) with Arm CPUs — traditional processors known for their small size and efficiency — and neural processing units (NPUs) — specialized processors for accelerating machine learning and artificial intelligence (AI).

Incorporating all these elements onto a single chip eliminates the complex orchestration that would otherwise be necessary between classical and quantum computing elements.

As long as you've got the space in a rack, all it requires is a standard electrical outlet: plug it in and it's ready to work, Equal1 representatives said.


* DeUKZjB37vsVNss2JNnwdZ-970-80.jpg.webp (42.6 kB . 970x546 - viewed 375 times)
(Image credit: Fergal Phillips)

The company's chip, called the UnityQ 6-Qubit Quantum Processing System, utilizes spin qubits, in contrast to many quantum computing platforms that rely on either trapped-ion or superconducting qubits.

Silicon-based spin qubits are compact, leading to potentially higher qubit density, and could leverage existing semiconductor fabrication techniques, meaning more scalability.

The chip fitted into the Bell-1 also incorporates error correction, control and readout, while taking advantage of existing semiconductor infrastructure for reliability and scalability.

The Bell-1 builds on advances first published by the company in December 2024, which established new peak performance marks for silicon qubit arrays as well as quantum controller chips.

These included the world’s highest recorded single-qubit and two-qubit gate fidelity (meaning fewer errors) and gate speed (meaning faster operations).

The platform also utilizes a specialized, AI-powered error correction system developed in partnership with Arm.
98
Generated under instruction by AI

Meth Cuts and Recrystallization Behavior

A visual guide to how common methamphetamine adulterants affect crystal formation.

🔬 Adulterant⚗️ Effect on Recrystallization🧊 Appearance When Cooled
💎 MSM (Methylsulfonylmethane)Delays or prevents; forms oily mix that resists solidifyingClear or cloudy oil that stays liquid
💧 Water (moisture contamination)Slows or halts; may result in syrupy consistencySyrupy or tacky layer that dries slowly
🧪 Acetone/Ether (solvent residues)MA remains dissolved; needs full evaporation to crystallizeOil with slow evaporation and delayed solidifying
☕ CaffeineHygroscopic; traps moisture and delays recrystallizationSticky mess; may remain brownish or clumpy
🌿 Ephedrine/PseudoephedrineMay recrystallize but introduces artifacts or stickinessPartial recrystallization with clouding
⚖️ dl-Methamphetamine (racemate)Slow, uneven crystal formation; may stay waxy or oilyWhite-yellow wax or smeared residue
🍬 Sugars (e.g., glucose, sucrose)Sticky or gooey residue; often caramelizes if heatedBurnt sugar smell; amber droplets
🥄 Baking soda / Soda ashForms cloudy or chalky paste; rarely crystallizesNo crystals, opaque mass
💊 Vitamin B powders (e.g., B1, B6)Creates colored powdery mix; does not recrystallizeChalky or powdery residue
🪨 Talc / Inert fillersRemains gritty or powdery; does not form crystalsDry but gritty and non-reactive

⚠️ Cut quality affects the burn, the hit, and your brain. Know what's in your shard.
99
Hallucinogens/Psychedelics / Psychedelics Rewire Brain-Immune Circuits
« Last post by smfadmin on May 08, 2025, 11:13:45 AM »
https://neurosciencenews.com/psychedelics-brain-immune-system-28830/

Psychedelics Rewire Brain-Immune Circuits

May 7, 2025

Summary:

New research reveals that psychedelics like psilocybin do more than alter brain activity — they reshape how the brain and immune system communicate.

Scientists identified a pathway where chronic stress disrupts amygdala signaling, triggering immune responses that increase fear and anxiety.

Psychedelic compounds reversed this process, calming immune cells and reducing fear behaviors, offering a potential breakthrough for treating psychiatric and inflammatory conditions. This marks a paradigm shift, suggesting mental health treatments may need to target neuroimmune circuits, not just neurons.

■ Key Facts:

● Neuroimmune Rewiring: Psychedelics reset brain-immune communication disrupted by chronic stress.

● Therapeutic Promise: This dual action may explain psychedelic benefits across psychiatric and inflammatory disorders.

● Paradigm Shift: Findings suggest mental health treatments should target both neural and immune pathways.

In a compelling Genomic Press interview published today, rising scientific star Dr. Michael Wheeler unveils revolutionary findings about how psychedelics reshape communication between the brain and immune system, potentially transforming treatments for psychiatric disorders and inflammatory diseases alike.

Bridging the Mind-Body Divide

As an Assistant Professor at Harvard Medical School and investigator at Brigham and Women’s Hospital, Dr. Wheeler stands at the frontier of neuroimmunology, a field exploring how the nervous and immune systems interact.


* psychedelics-immune-system-neurosciecne-1155x770.jpg.webp (44.8 kB . 1155x770 - viewed 409 times)
Remarkably, psychedelics can interrupt this process at multiple points, reducing both immune cell accumulation and fear behaviors. Credit: Neuroscience News

His groundbreaking research, recently validated in Nature (April 23, 2025; "https://doi.org/10.1038/s41586-025-08880-9"), demonstrates that psychedelics like psilocybin don’t just affect neurons: they fundamentally reshape immune responses tied to fear and stress.

“We found that astrocytes in the amygdala use a specific receptor called EGFR to limit stress-induced fear,” explains Dr. Wheeler. “

When chronic stress disrupts this signaling, it leads to a cascade involving brain-resident cells and immune cells that ultimately increases fear behavior. What is fascinating is that psychedelic compounds can reverse this entire process.”

This finding represents a paradigm shift in understanding psychedelics’ therapeutic potential. Rather than simply acting on neural pathways, these compounds appear to recalibrate entire neuroimmune circuits.

Could this dual action explain why psychedelics show promise across diverse conditions from depression to addiction? And might they eventually prove useful for treating inflammatory disorders that have no apparent psychiatric component?

From Legal Defender to Brain-Immune Explorer:

Dr. Wheeler’s journey to this breakthrough began in an unexpected place, the Public Defender’s office in Baltimore City.

“I felt that the actions of the people we defended were so inextricably linked with their environmental circumstances, inclusive of physical or emotional abuse beyond their control, that I was desperate to understand the inner workings of their minds,” Dr. Wheeler reflects.

This early experience shaped his scientific mission to unravel how environmental factors—including stress and trauma—reshape our internal neurobiology.

Following this passion, he made the courageous decision to join the lab of an immunologist during his postdoctoral training despite having no background in the field.

“One of the most intimidating choices I made was joining the lab of an Immunologist during my post-doc,” notes Dr. Wheeler.

“I only trained in Neuroscience at that point, so when I looked at Francisco’s papers on dendritic cells and T cells, I was nervous about what I was getting into.”

This interdisciplinary leap proved transformative and by bringing together insights from neuroscience and immunology, Dr. Wheeler identified previously hidden communication channels between the brain and immune system that may help explain why traditional psychiatric treatments often yield inconsistent results.

Mapping the Brain-Body Interface

Dr. Wheeler’s laboratory employs cutting-edge technologies including genomic screening, single-cell analysis, and behavioral studies to create what he describes as a “wiring diagram” of brain-immune communication.

His team’s recent Nature publication demonstrates that when chronic stress disrupts normal signaling in the amygdala—a key brain region for processing fear—it triggers an inflammatory cascade involving immune cells in the meninges (the protective membranes surrounding the brain).

Remarkably, psychedelics can interrupt this process at multiple points, reducing both immune cell accumulation and fear behaviors.

This research raises intriguing questions about traditional approaches to psychiatric disorders.

If mental health conditions have significant immune components, might we need to rethink treatment strategies that focus exclusively on neurotransmitters? Could new therapeutic agents that target both neural and immune pathways prove more effective than current options?

Looking ahead, Dr. Wheeler envisions a revolution in thinking about neuropsychiatric disorders.


“I am excited about the prospect of identifying brain-body communication loops as a fundamental feature of physiology,” he states.

“Often, we think of mental health disorders based on their behavioral symptoms. However, we are likely leaving much underlying biology on the table by focusing solely on the brain.”

Team Science and Cross-Disciplinary Collaboration

Dr. Wheeler emphasizes that his success stems from collaborative team science rather than solitary genius. As a laboratory leader, he values bringing together people with diverse scientific backgrounds to create synergistic insights that no individual could achieve alone.
100
https://www.livescience.com/technology/artificial-intelligence/us-air-force-wants-to-develop-smarter-mini-drones-powered-by-brain-inspired-ai?utm_term=032043BB-1CB4-4440-A845-2FF7DCCBD37B&lrh=1e7f7a9239bb44f191dc979b8fe5e634e587dfe020b84a653d2040468a8b342b&utm_campaign=368B3745-DDE0-4A69-A2E8-62503D85375D&utm_medium=email&utm_content=83303A6A-B062-4168-AED9-969C76D730B6&utm_source=SmartBrief

US Air Force wants to develop smarter mini-drones powered by brain-inspired AI chips

May 5 2025

Plans are underway to create new AI-powered drones that can fly for much longer than current designs


* itNaNmkkKnSUjPxXWcKiPk-970-80.jpg.webp (38.34 kB . 970x546 - viewed 367 times)
Although neuromorphic computing was first proposed by scientist Carver Mead in the late 1980s, it is a field of computer design theory that is still in development. (Image credit: Anton Petrus/Getty Images)

Scientists are developing an artificial intelligence (AI) chip the size of a grain of rice that can mimic human brains — and they plan to use it in miniature drones.

Although AI can automate monotonous functions, it is resource-intensive and requires large amounts of energy to operate.

Drones also require energy for propulsion, navigation, sensing, stabilization and communication.

Larger drones can better compensate for AI's energy demands by using an engine, but smaller drones rely on battery power — meaning AI energy demands can reduce flying time from 45 minutes to just four.

But this may not be a problem forever; Suin Yi and his team at the University of Texas have been awarded funding by the 2025 Air Force Office of Scientific Research Young Investigator Program (part of the Air Force Office of Scientific Research) to develop an energy-efficient AI for drones.

Their goal is to build a chip the size of a grain of rice with various AI capabilities — including autonomous piloting and object recognition — within three years.

AI-powered miniature drones:

To build a more energy-efficient AI chip, the scientists propose using conducting polymer thin films.

These are (so far) an underused aspect of neuromorphic computing; this is a computer system that mimics the brain’s structure to enable highly efficient information processing.

The researchers intend to replicate how neurons learn and make decisions, thereby saving energy by only being used when required, similar to how a human brain uses different parts for different functions.

Although neuromorphic computing was first proposed by scientist Carver Mead in the late 1980s, it is a field of computer design theory that is still in development.

In 2024, Intel unveiled their Hala Point neuromorphic computer, which is powered by more than 1,000 new AI chips and performs 50 times faster than conventional computing systems.

Meanwhile, the Joint Artificial Intelligence Center develops AI software and neuromorphic hardware.

Their particular focus is on developing systems for sharing all sensor information with every member of a network of neuromorphic-enabled units.

This technology could allow for greater situational awareness, with applications so far including headsets and robotics.

Using technology developed through this research, drones could become more intelligent by integrating conducting polymer material systems that can function like neurons in a brain.

If Yi’s research project is successful, miniature drones could become increasingly intelligent.

An AI system using neuromorphic computing could allow smaller and smarter automated drones to be developed to provide remote monitoring in confined locations, with a much longer flying time.
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