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« Last post by Chip on June 02, 2025, 02:04:11 PM »
🔥 Piperine Synergy & PotentiationPiperine is the primary active alkaloid in black pepper ( Piper nigrum) and functions as a powerful bioavailability enhancer, modulating both Phase I (CYP450) and Phase II (glucuronidation) metabolic pathways.
🧬 Key Mechanisms- Inhibits CYP3A4, CYP2D6, CYP2E1 – Slows drug metabolism
- Blocks UDP-glucuronosyltransferase (UGT) – Prevents rapid excretion
- Enhances absorption via intestinal epithelial permeability
- Increases thermogenesis and blood flow in the gut
⚡ Optimal Dosage| Formulation | Typical Dose | | Piperine extract (BioPerine®) | 5–20 mg | | Black pepper (powdered spice) | 250–500 mg |
🧠 Therapeutic effect begins at 5 mg of standardized piperine extract. Doses over 20 mg may cause GI irritation.
🔥 Substances Potentiated by Piperine🧠 Nootropics & Neuromodulators- Curcumin – Up to 2000% ↑ absorption
- Resveratrol – Higher blood plasma retention
- 5-HTP – Slower breakdown, stronger mood support
- L-DOPA / Mucuna – Prolonged dopaminergic effect
- Phenethylamine (PEA) – Longer duration, stronger stimulation
- Hordenine – Extended TAAR1 activity
- Caffeine – Slower metabolism, extended half-life
- Modafinil – Mild potentiation of wakefulness
💊 Supplements & Adaptogens- Berberine – Enhanced glucose modulation
- Quercetin – Amplified antioxidant effects
- Bacopa Monnieri – Improved cognitive support
- CoQ10 – Greater mitochondrial delivery
- Melatonin – Longer sleep duration
- Fat-soluble Vitamins (A, D, E, K) – Improved absorption
🌿 Cannabinoids- CBD / THC – Increased potency and duration
⚠️ May raise anxiety levels at high doses
⏱️ Timeline of Effects| Time After Ingestion | Effect | | 0–10 min | Initial absorption in GI tract begins | | 10–30 min | CYP/UGT enzyme inhibition takes effect | | 30–45 min | Peak potentiation of target substances | | 1–3 hours | Sustained enhancement of absorption/metabolism | | 3–6 hours | Gradual return to baseline enzyme activity |
🚨 ⚠️ Pharmaceutical Interactions ⚠️ 🚨Due to CYP and UGT inhibition, Piperine may dangerously increase levels of: - Benzodiazepines (Diazepam, Clonazepam)
- SSRIs / SNRIs (Sertraline, Venlafaxine)
- Opioids (Morphine, Oxycodone)
- Beta-blockers (Metoprolol, Atenolol)
- MAO inhibitors – Hypertensive risk
- Anticoagulants (Warfarin) – Bleeding risk
❗ Avoid combining piperine with narrow therapeutic index medications unless supervised by a medical professional.
⚙️ Integration Tips- Dose 10–15 minutes before target compound
- Use 5–10 mg Piperine extract, or 250–300 mg black pepper powder
- Cycle use to avoid enzyme over-inhibition or tolerance
🧠 Notes for Formulators- Piperine is lipophilic – combine with fats or oils for best effect
- Highly synergistic with methyl donors, dopaminergics, and anti-inflammatory agents
- Acts as a natural AMPK modulator, supporting metabolic and neuroprotective stacks
Created for Neurostack Optimization — by Chipper 🔗 GitHub Repo: NeuroOverride Stack
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My fellow dinosaurs still on buckets:
Im frustrated by Bucket Blowout Syndrome BBS. Its not uncommon for the spile to tear through the sidewall of my plastic bucket, spilling a good amount of sap. Bucket quality and age probably factor in. Ive tried different spiles. Several years ago I used the cast aluminum "shark fin" spiles that easily tore through the bucket above the hole. I tried inserting a washer between the fin and the bucket wall but that was cumbersome. Im currently using Sap Meister spiles that have a built-in washer but they tear through also.
Any ideas on how to prevent? Ive tried running tubing to a bucket on the ground but that takes time to setup with different lengths of tubing each year.
Thanks for ideas.
Marc
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Extensor action
A discussion has arisen about extensor action in oz forum,hopefully we can find out more here on the home of TGM.
ADVANTAGES.....what are the advantages? .Can it be overdone?....and what are the signs of overkill in extensor action
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Quite a few, actually all 45s. I do not recheck often, so not sure how many are still truly UTR at least dozens, possibly hundreds. Still lots out there IMO, but as mentioned above, how many are any good?
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"You must take your opponent into a deep, dark forest, where 22=5, and the path leading out is only wide enough for one"
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« Last post by smfadmin on June 01, 2025, 03:48:44 PM »
HOW TO RESPECT YOURSELF
1. Stop begging others.
2. Stop saying more than necessary.
3. Stop looking for who is not looking for you.
4. Invest in yourself and make yourself happy.
5. Stop entertaining gossip about other people.
6. When people disrespect you, confront them immediately.
7. Don't eat other people's food more than they eat yours.
8. Always look your best; dress the way you should be addressed.
9. Reduce how often you visit some people, especially if they don't reciprocate
10. Think before you talk; 80% of how people value you is what comes out of your mouth.
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« Last post by smfadmin on June 01, 2025, 03:14:18 PM »
Your post is irrelevant so why post it here ?
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i would check out the quality of ikon shocks before you buy your next set terry . they used to be great when they were made in australia but the last set i bought were not so good . when i checked the box it said assembled in australia so i guess they are now made in china .
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An interesting or I thought interesting question came up during a discussion with a couple of my good friends.
While discussing Calvinism, Armenianism and Open Theism one of us asked if God can change the past? Now the context is that I am Armenian, but do lean towards Open theism. My one friend is soundly in the middle and the other is Armenian, but leans pretty well to the Calvinist position in many ways.
So one asked if God can change the past. I had been arguing the Open position that God cannot "know" the actual future because it doesnt exist. Time is not a literal, tangible contruct. It isnt a linear "string" with any actual points on it that can be visited. So, according to the Open Theism position, God knows every possible outcome and every possible consequence of every possible choice we can make in every situation...but cannot know the actual choice itself that we will make because until it is made...it has not happened. There IS no future yet that can be known. The lone exception, as any Open theist would readily admit, is in the instances of actual prophecy where God essentially just asserts His absolute will and demands an outcome.
While my one friend was disagreeing, the other asked "can God change the past". His point was that if we come to the conclusion that God cannot change the past because there actually IS NO past to change, then how can we then say God can know the actual choice we will make, and therefore know the actual future and not just every potential future. If the past is not tangible in a sense, like a point on a string behind us, then why do so many assume the future is tangible in a sense? If the string behind us doesnt really exist, then why do we assume the string in front of us does?
It mostly would make time merely a series of "now" where the past and future are NOT actually places but merely constructs of our memory and recorded history. You wuldnt be able to go back to yesterday because yesterday doesnt actually exist. All yesterday is is a series of moments that we lived and happen to remember. It cannot be gone to becuase it never really was a place.
So if that summation is incorrect in your opinion, then can God actually change the past? Can God go back to yesterday and change what you were eating or dinner? Or if a loved one died tragically, can God go back and prevent it? If you say yes, then wouldnt that require God to re-write all of reality, time and space and our memories from the moment of change forward? God would have to erase the butterfly effect right?
Or is God unable to change the past? And if He cannot change the past, then why is the future any different assuming the nature of time itself is constant?
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You could think of it as an opportunity to improve your skills as an instrument chaplain.
Its a bigger part of the job than I ever thought it would be.
Part of cradle to grave service.
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