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Just wanted to open a discussion around psychedelic products—ranging from classics like LSD and psilocybin to newer or less mainstream options like DMT vape pens, mescaline extracts, and even microdose blends that are starting to pop up.
Over the past few years, there's been a noticeable shift in how people view these substances. What was once niche or underground is now being talked about in the context of mental health, self-growth, and even spiritual exploration. But with that shift, there’s also been a rise in commercial products—some great, some questionable.
🔍 Types of Psychedelic Products I’ve Seen Recently:
Psilocybin chocolates/gummies – Easy to dose, tastes way better than dried mush.
LSD microdose tabs/blotters – Usually sold in 5–15µg doses.
DMT vape pens – Super convenient but hit hard and require respect.
Ayahuasca analogues – Peganum harmala + DMT-containing plant blends.
“Mushroom capsules” with blends – Often combined with adaptogens or nootropics.
💬 Some Questions for the Community:
Anyone else noticed the influx of these products in the underground scene or online markets?
Have you tried any of these more “branded” or commercialized versions vs. traditional/raw forms?
Do you feel these products make psychedelics more accessible or take away from the experience?
What harm reduction tips would you offer for people trying these newer formats?
🧠 A Note on Intentions:
As psychedelics become more mainstream, I think it’s important not to lose sight of why we’re using them. Whether it's healing trauma, reconnecting with yourself, breaking patterns, or just exploring consciousness, having a clear intention can make all the difference between a trip that changes your life and one that just leaves you confused.
Of course, not every experience has to be super deep—but in my opinion, respect and preparation go a long way.
Would love to hear people’s thoughts, stories, or even recommendations. Let’s keep it harm-reductive and non-judgmental. ✌️
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Hey everyone,
I wanted to open up a discussion around 5-MeO-DMT—sometimes called the "God molecule"—and hear from folks who’ve worked with it, or are considering it. It seems to have a reputation that’s very different from other psychedelics, and I'd love to get some deeper insight from this community.
What is 5-MeO-DMT?
For those newer to it: 5-MeO-DMT is a powerful, naturally occurring tryptamine, found in certain plants, toads (Bufo alvarius), and also synthesized. It’s not the same as N,N-DMT—it’s often described as more non-dual, ego-dissolving, and less “visual,” though it varies a lot by person and dose.
A Few Questions I’m Exploring:
How would you describe the difference between 5-MeO-DMT and N,N-DMT (the “classic” DMT)?
What mindset and setting do you think are essential for working with this substance? I’ve read that it can be extremely destabilizing if not approached with care.
Plugging vs vaping vs insufflation – what are the major differences in onset, duration, and intensity?
Did it change anything for you? Spiritually, mentally, or emotionally? Temporary or lasting?
What I’ve Learned So Far (from reading, not personal experience yet):
It’s not recreational. People describe it as “dying before dying.”
Integration seems huge after an experience—people report bliss, but also confusion, emotional upheaval, or dissociation if not prepared.
There are risks, especially with dose titration. Going too hard can be traumatic or dangerous (there are stories of seizures, blackouts, or extreme panic).
Set, setting, and sitter are more important here than with maybe any other psychedelic.
If you've had experience with 5-MeO-DMT (synthetic or from toad), I’d love to hear:
How you prepared
What dosage you worked with
How you integrated the experience afterward
Any advice or red flags you’d offer to someone approaching this substance for the first time
Let’s keep this grounded in harm reduction, consent, and respect for the power of this compound. I'm not looking to source it, just trying to learn from those who’ve walked the path.
Thanks in advance for sharing your wisdom and stories.
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Hey everyone,
I’ve recently come across a new psychedelic product that’s been making the rounds in some online spaces, and I thought it would be good to open a discussion here to see if anyone has tried it or has any thoughts.
The blend is marketed as a "microdose + visionary" combo, supposedly designed to balance the clarity and focus of a microdose with a subtle entheogenic push. It's a mix of:
Psilocybin extract (sub-perceptual dose)
Harmala alkaloids (MAOI, very low dose)
Lion’s Mane + Niacin (for neurogenesis support)
And a touch of blue lotus for relaxation
I haven’t tried it yet—doing my research first—but I’m curious about a few things:
Stacking harmalas with psilocybin: I've heard mixed opinions about whether this significantly changes the experience. Some say it adds depth or duration, others caution about intensity. Thoughts?
Neuroplasticity stacks: Anyone here had success combining Lion’s Mane and psilocybin long-term? Did you notice any mood or cognitive benefits?
Legality & sourcing: I’m NOT asking where to get it, just wondering if anyone’s seen similar legal versions (like the ones with Amanita extracts or lab-synth analogues) being sold where they are.
I think what interests me most is the intentionality behind this blend—it seems aimed less at tripping and more at mental wellness or introspection. Of course, there’s always a need to be cautious with combinations, especially involving MAOIs.
Would love to hear:
Any experiences with similar blends or stacks
Dosage tips if you’ve done something like this
Any red flags you’d suggest watching for
Let’s keep this grounded in harm reduction, science, and shared insight. Appreciate the space and the community here.
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« Last post by smfadmin on August 29, 2025, 09:26:44 AM »
🧠 Dopamine & MA + Piperine / Hordenine Stack — Condensed Notes
1. Piperine + Dopamine Receptors
💊 Piperine **does NOT directly increase dopamine receptor sensitivity**
⚡ Main effect: **CYP3A4/CYP2D6 inhibition**, slows MA metabolism → higher, longer dopamine
🧪 Mild **MAO inhibition** possible
⚠️ High doses (200 mg+) → gut irritation, unpredictable effects
2. Effects of MA + Piperine
⏳ Slower onset, **sharper peak once absorbed**
📈 **Extended plateau** → longer functional stimulation
❌ Piperine increases exposure, **does not restore receptor sensitivity**
3. Hordenine + MA + Piperine
🌿 Hordenine: **NRI + mild TAAR1 activity**, additive with MA
⏱ Piperine slows Hordenine clearance → stronger effect
💥 Combined: higher norepinephrine + dopamine, longer duration, elevated HR/BP
⚠️ Not a resensitizer — stresses desensitized receptors
4. Timeline of Effects (150 mg MA + 200 mg Piperine + 450 mg Hordenine)
| Time | Effect |
|------------|--------|
| 0–0.5 hr | Mild alertness, delayed onset |
| 0.5–2 hr | Rising phase; jitters, mild jaw tension |
| 2–6 hr | Peak/plateau; functional stimulation, motivation, cardiovascular load |
| 6–12 hr | Declining; wired tail, restlessness, appetite suppression, sleep disruption |
| 12–24 hr | Comedown; fatigue, low mood, mental fog, gut irritation |
5. Dopamine Receptor Resensitization
🔹 High MA tolerance → D1/D2 downregulation
🔹 Recovery = **rest receptors, not more dopamine**
Recovery Protocol (60 × 1000 mg CDP-Choline)
💊 Core Stack:
- CDP-Choline: 250–500 mg AM with food/fat
- Omega-3 (DHA/EPA): 1000–2000 mg/day
- Magnesium glycinate/threonate: 200–400 mg PM
🧩 Optional Builders:
- Uridine Monophosphate: 150–250 mg AM
- NAC: 600–1200 mg/day
- B-vitamins: B6, B9, B12
🏃 Lifestyle:
- Exercise 3–5×/week → boosts D2 receptor density
- Solid sleep → receptor density rebounds
- Novelty/learning → natural dopamine stimulation
⏱ Timeline:
- 1–2 weeks → subtle clarity/focus
- 1–2 months → reward sensitivity improves
- 3+ months → motivation rebound
- 3–6 months → major receptor recovery (if MA minimal)
⚠️ MA Use During Recovery:
- Low-dose or spaced out only
- Micro-dosing occasionally okay, frequent use slows recovery
6. CDP-Choline Notes
- Supports **receptor density, synapse repair, membrane health**
- Works best with **DHA + uridine**
- Dose: 250–500 mg/day, split 1000 mg capsules
- Benefits over **weeks–months**
- Supply: 60 × 1000 mg → ~4 months at 500 mg/day
7. Safety & Warnings
- MA + Piperine + Hordenine → increased cardiovascular load; monitor HR/BP
- Piperine prolongs clearance → longer effects
- Gut irritation, restlessness, insomnia possible
- Stack **does NOT resensitize receptors**; repeated use worsens tolerance
8. TL;DR
- ⚡ Piperine = metabolic amplifier, not receptor fixer
- 🧠 CDP-Choline + DHA + uridine + magnesium + lifestyle = true receptor rebuilding
- 🚀 MA/Hordenine/Piperine = functional boost, long tail, receptor stress
- 🔑 Recovery = **time off stimulants + nutrition + exercise + sleep**
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« Last post by smfadmin on August 25, 2025, 10:55:55 PM »
https://www.psychiatrist.com/news/songs-that-shape-our-memories/?utm_source=Klaviyo&utm_medium=email&utm_campaign=news_weekly&klid=01HYSTTNXNB74YAYKT9XMYQCN0&_kx=va3uRF3O8-7Dg_zjrKMZJk0wdery-TOTVyZ3l8muM1g.VpkqxCSongs That Shape Our MemoriesAugust 21, 2025 Clinical relevance: Songs don’t just trigger memories. They can determine which ones spring to mind and how powerful they are. A large new study shows that a song’s acoustic features influence which memories surface and how strongly they resonate. High-energy tracks tend to spark fast, social memories, while acoustic songs evoke slower, more deeply personal recollections. The findings could guide therapies n by tailoring playlists to patient needs. For most of us, a familiar song can be a time machine. It can instantly take us back to our first kiss, an early heartbreak, or an unforgettable road trip. Now, new research from Goldsmiths, University of London, shows that the sound of a song can help shape which memory pops up. They can even influence how hard those memories hit. The study, published in PLOS One, is the largest so far to directly tie the acoustic features of music to the qualities of music-evoked autobiographical memories (MEAMs). And the results could determine therapies for a host of mental health issues, such as dementia and depression. It can also shed new light on how memory and music interact. A Large-Scale Look at Musical Memory: Psychologists Safiyyah Nawaz and Diana Omigie recruited 233 adults, between the ages of 18 and 76, to participate in their online experiment. The researchers asked each participant to pick a song that meant something to them and describe the memory associated with it. They also rated the memory’s vividness, importance, and emotional tone. Later, they listened to 10 short clips of songs culled from the Billboard Hot 100 charts during their formative years (ages 9 to 19, a crucial time for music-related memories). If a song sparked something, participants again rated the recall for detail and emotional content. Throughout the study, participants provided more than 1,400 music-evoked memories. It was enough to allow the researchers to analyze not only what people remembered, but why certain songs wield such power. Using Spotify’s Web API, the team managed to isolate nine auditory features from each memory-evoking track, including energy, loudness, acousticness, tempo, and danceability. A subsequent statistical analysis revealed a single critical factor, which the researchers dubbed energeticness-acousticness (E-A). One end of the spectrum featured energetic, loud, electronic or dance-oriented songs. And the other? Quieter, more acoustic tracks. Different Sounds Mean Different Memories: The contrast between high-energy and acoustic songs mapped neatly onto differences in the types of memories they brought forth: High-energy songs (like club tracks or pop anthems) tended to elicit memories marked by excitement, amusement, and social interaction. Listeners typically associated these songs to concerts, parties, or some other group event. Lower-energy, more acoustic tracks (like ballads or classical compositions) seemed to be more likely to elicit memories that the participants described as vivid, unique, and personally important. Listeners associated these emotional tunes to a sense of calmness, sadness, romance, or aesthetic appreciation. Notably, acoustic songs often evoked memories brimming with more negative emotion words. Even so, the participants still rated these recollections as overall positive experiences. That paradox, the authors point out, underscores music’s ability to reframe painful events in a more forgiving light. The researchers also looked at how quickly – and vividly – memories surfaced. Participants recalled energetic songs (and the memories tied to them) more quickly and more often. While acoustic tracks prompted slower recall but produced longer, more detailed memory descriptions. Simply put, upbeat music performed better when triggering many memories, but quieter music tended to yield more powerful ones. One striking difference emerged between self-selected songs and experimenter-chosen chart hits. Listeners consistently rated memories tied to personally chosen songs as more vivid, emotional, unique, and important. They also contained more specific sensory details. This, the authors suggest, hints that while the acoustic profile of a song matters, a personal connection might matter even more. Why This Matters: The findings carry implications for both psychology and clinical practice. Dementia caregivers are already using music-based reminiscence therapy to spark forgotten episodes and strengthen identity. Knowing which song types are most likely to evoke vivid or social memories could help therapists tailor playlists to patient needs. For example, upbeat, high-energy songs might be useful for encouraging social engagement, while acoustic ballads could help surface personally meaningful life stories. The study also emphasizes the need to move beyond simple “positive versus negative” emotional models. By tracking specific categories like romance, aesthetic appreciation, or amusement, the researchers make a case that music can cue up a far richer emotional palette than earlier two-dimensional models of arousal and valence suggested.
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« Last post by Jamesstymn on August 25, 2025, 05:53:55 PM »
Yo, people I just found something useful and I had to share it. You know how drugstores are always a struggle when you look for rare meds? Sometimes the cost is ridiculous, sometimes they just don’t have it, and sometimes you waste hours. Well, I came across a platform with a giant catalog of medical products. Not just a couple of basic pills, but an entire marketplace: from painkillers and vitamins. Ditropan;Oxybutynin;Gastrointestinal Tract;5mg Why is this useful? Seriously, we’ve got better things to do. Here you just click a button — and problem solved. A real-life case Recently I was searching for a rare drug. I checked three big chains and it was out of stock everywhere. Online? Solved in a few clicks. The assortment is huge You can find whatever you need: from vitamins and supplements to rare imports. No more wasting gas and time. Modafresh;Modafinil;Other, Sleep Aid;200 mgAnother bonus: prices are often more affordable than local drugstores. My opinion To be fair, I thought it would be harder. Now I’m curious: would you give it a shot? Share your experience in the comments — I bet many of you have interesting cases. Hi everyone! It may sound surprising, but the list is pretty impressive. We’re talking about a wide range: from common everyday problems to long-term health issues that usually require multiple visits to the drugstore. Instead of standing in queues, you can now order what you need online in minutes. What kind of diseases are we talking about? weight reduction in a big wayThe range covers a crazy number of options: - respiratory issues - allergies - headaches & migraines - diseases that need regular medication You can quit stressing in local stores. Why I think this is important PseudomembranousIt’s not just about convenience. Online pharmacies solve the main pain point: affordable prices. Honestly, I was shocked when I saw how many health problems can be treated with the help of an digital medicine store. Now I’m curious — have you ever tried using online pharmacies? Share your thoughts in the comments — I bet many of you have stories. I want to order Zyrtec — tell me the website? How to save buying Cialis online without prescription Drugs at late hours? Just online! Is it safe to order medicines online in 2025? No more embarrassment at the pharmacy 22b414f @medical453.comby
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« Last post by smfadmin on August 10, 2025, 01:01:38 PM »
Don’t fully trust your friends. Sometimes, you learn more from those who disagree with you.
Speak less than needed. Silence often says more than words.
Don’t try to look perfect all the time. People get jealous or suspicious.
Learn when to act and when to wait. Timing matters.
Show your worth through what you do, not by arguing.
Know when to stop. Winning too much can backfire.
Don’t cut yourself off from everyone. Being alone too much is risky.
Sometimes stepping away makes people value you more.
Focus your energy on one goal instead of spreading it thin.
Think your own way, but blend in when needed.
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« Last post by smfadmin on August 08, 2025, 06:08:56 AM »
https://www.livescience.com/space/mars/nasa-finds-multi-billion-year-old-coral-on-mars?utm_medium=referral&utm_source=pushly&utm_campaign=Space%20Audience8 Aug, 2025 NASA's Curiosity rover has snapped black and white images of a rock on the Martian surface that looks remarkably like a piece of coral. The strange object is in fact a small, light-colored, wind-eroded rock, which the rover found inside the Red Planet's Gale Crater on July 24 — but it looks remarkably similar to the reef-building creatures found in Earth's oceans. A black and white picture taken with Curiosity's Remote Micro Imager — a high-resolution, telescopic camera that is mounted on the rover — and shared by NASA in a statement on Aug. 4 shows the approximately 1-inch-wide (2.5 centimeters) rock with its intricate branches. "Curiosity has found many rocks like this one, which were formed by ancient water combined with billions of years of sandblasting by the wind," NASA representatives wrote in the statement. Coral-shaped rocks on Mars started forming billions of years ago, when the Red Planet still had water, according to the statement. Just like water on Earth, this water was full of dissolved minerals. It percolated through small cracks in Martian rocks, gradually depositing minerals and forming solid "veins" inside the rocks. These veins form the strange branches of the coral-shaped object that we see in Curiosity's picture today, after millions of years of erosion by sand-laden winds wore away the rock. The article continues at the source link ... The Curiosity rover discovered what looks like coral on Mars. (Image credit: NASA Jet Propulsion Laboratory):
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« Last post by Chip on August 07, 2025, 08:25:20 AM »
That's excellent news Mr Pooper, that you're mobile again; sadly, I have lost my license for 3 years so I get it so you have more reasons to smile about now. I ran your reply through AI again and this is the reply: 🧪 Ongoing Fentanyl Positives Despite Abstinence – Full Case & Update“I’ve been clean for almost a year, yet my clinic keeps saying I’m positive for fentanyl. Dipsticks and home tests are negative, but the lab says positive. My credibility is being destroyed.”--- 🚨 Summary of the Issue- Stopped using fentanyl and meth in September
- Multiple random fentanyl positives despite months of clean results in between
- Methadone given in dissolvable disc pills, sometimes handled without gloves
- Environmental contamination suspected
- Now a pattern: dipstick test = negative, lab test = positive
--- 📅 Update from Patient“So a little update. I’m STILL getting positives for fentanyl at my methadone clinic. They do a dipstick test before sending the urine sample to the lab. It’s tested NEGATIVE every time with the dipstick test. But once sent to the lab, they are claiming it’s detected POSITIVE for fentanyl.
I’ve even gone as far as to do my own at-home fentanyl urine test, and they test NEGATIVE every time. I even got fentanyl test wipes to test surfaces for fentanyl.
It seems like I’ll get a few dirty tests, then one clean. Few dirty tests, then one clean.
My clinic is flat-out accusing me of using. They claim it’s impossible to have this many false positives. I asked if anyone else was having similar issues — they said no. They occasionally have false positives, but not 5+ like me.
I’m really upset by this. Being accused of using, despite being clean for almost a year, is a horrible feeling. And now with the added urine tests claiming positive drug use, my credibility is shot, and it’s making me untrustworthy.”
--- 🧪 1. Possible Explanations🔹 A. Environmental Contamination Possible, though rare. Fentanyl can transfer via skin oils if staff handle contaminated items and then handle medication. One contaminated pill could cause a positive. 🔹 B. Ultra-Sensitive Lab Testing Labs may use cutoffs as low as 1–2 ng/mL, so even microscopic contamination can trigger a positive. This could explain why dipsticks (less sensitive) are negative but lab results are positive. 🔹 C. Stored in Fat Tissue? Unlikely given the random pattern and long gaps between use and positives. 🔹 D. False Positives at the Lab Uncommon for fentanyl, but possible with lab error, cross-contamination, or issues in sample handling. --- 🧾 2. Steps to Prove Cleanliness✅ A. Request GC/MS or LC-MS/MS Confirmation These tests can: - Differentiate fentanyl from analogues
- Show exact nanogram level
- Confirm if metabolites are present (proves ingestion)
Say: “Can I have every positive urine sample sent for GC/MS confirmation before any action is taken?”✅ B. Independent Testing On the same day as your clinic test: - Do an independent lab urine test
- Do a hair follicle test for 90-day history
✅ C. Document Everything Track: - Every clinic test result
- Every independent test result
- Handling conditions of methadone
✅ D. Evidence of Pill Handling Practices Note glove use, packaging methods, and storage conditions. Consider requesting a change to liquid methadone or blister packs. --- 🛡️ 3. What to Say to the Clinic
“I’ve been clean since September. My clinic dipstick tests are always negative, and my at-home tests are negative, yet the lab reports positives. This suggests there is either contamination or lab error.
I am not accusing anyone of misconduct, but I am asking for GC/MS confirmatory testing on all positives, and I’d like to explore ways to avoid any possible contamination in handling or packaging of my doses.”
--- 👩⚖️ 4. If the Clinic Refuses to Cooperate- File a written request for confirmatory testing
- Contact your state’s Patient Advocate or Ombudsman
- Consider a clinic transfer
--- 🧷 TL;DR Action Plan✅ Request GC/MS confirmation on all positives ✅ Get independent lab + hair tests same day as clinic ✅ Keep detailed documentation log ✅ Request sealed or liquid doses to avoid contamination risk ✅ Stay professional, polite, and persistent --- 💬 Final Note Intermittent positives with all on-site and home tests being negative point toward either environmental contamination or lab processing issues. Without GC/MS confirmation, it’s impossible to know which — but persistence and independent verification can protect your credibility. (AI reply finished)@Mr.pooper, tell them if you were using Fentanyl (and its stored in your fatty tissue for a while) then you'd have ALL tests positive and you'd be in opi withdrawal on the negative days and need more Methadone (which you do not as I assume that you're stable now). Any chance of changing clinics or getting a GC/MS or a hair follicle test ?
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« Last post by Mr.pooper on August 06, 2025, 11:45:01 PM »
So a little update. Im STILL getting positives for fentanyl at my methadone clinic….they do a dipstick test before sending the urine sample to the lab. Its tested NEGATIVE every time with the dip stick test. But once sent to the lab, they are claiming its detected POSITIVE for fentany.
ive even gone as far to do my own in home fentanyl urine test, and they test NEGATIVE every time. I even got fentanyl test wipes to wipe down things in my environment to test surfaces for fentanyl.
It seems like ill get a few dirty tests. Then one clean. Few dirty tests. Then one clean.
My clinic is flat out just accusing me of using. Claiming it’s impossible to have this many false positives
I asked if anyone else was having similar issues, and they said no. They occasionally have false positives, but not 5+
Im really upset by this. Being accused of using, despite being clean for almost a year is a horrible feeling. And now with the added urine tests claiming positive drug use, my credibility is shot, and making me untrustworthy.
On a positive note, I managed to get my drivers license and purchased a 2016 suv. I had to work hard to get that drivers license too! I had to take the written test and do a on road driving test like when i was a teenager..i never thought id ever legally be able to drive again, or own a car ever again. So im really proud to have ID and a car w/ legal papers. I also just got my new teeth! The dentist instructed me to smile and look at them in a mirror, and I realized i didnt know how to smile anymore. Ive been sad for so long, and on top of missing most my teeth, i never smile anymore. To the point i dont even have the facial muscles to do it anymore.
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