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21

Phenethylamines / Methamphetamine Bioavailability by Route of Administration

« Last post by smfadmin on November 07, 2025, 01:13:48 PM »

Methamphetamine Bioavailability by ROA

IV (Injection): ~100% 
Direct systemic entry. Highest vascular + infection risk.

Smoking (Freebase Vapor): ~90–98% 
Fastest onset + hardest reinforcement loop (most addictive).

Insufflated (Snorted): ~70–90% 
Varies with pH + technique. Chronic sinus damage common.

Oral (Swallowed): ~62–79% 
Smoothest curve, longest duration, lowest compulsion spike.

Rectal (Plugging): ~70–80% 
Avoids most first-pass. Stronger and faster than oral.

Sublingual / Buccal: ~50–60% 
Most swallowed; inconsistent absorption.

IM (Intramuscular): ~80–90% 
Slower than IV, weaker rush. Infection risk still present.


Onset & Reinforcement Profiles

Smoking / IV: Seconds | Highest DA spike → strongest addiction loop 
Snorted / Rectal: 3–10 min | Moderate reinforcement 
Oral: 20–45 min | Lowest reinforcement, more stable use pattern


Harm Reduction Guidance

• If aiming to control tolerance → choose Oral or Rectal 
• Smoking and IV accelerate tolerance fastest 
• Keep minimum 72 hours spacing between runs 
• Avoid stacking stimulants with sleep deprivation


Supplements That Provide Actual Benefit

• Magnesium – NMDA regulation 
• NAC – reduces oxidative stress + glutamate dysregulation 
• DHA / Omega-3 – neuronal membrane stabilization 
• Vitamin C – antioxidant + post-run recovery 
• Adequate Sleep – mandatory for synaptic reset


Summary: 
Snorting wastes drug + damages tissue. 
Smoking/IV = strongest dopamine spike → steep tolerance ramp. 
Oral/Rectal = smoother kinetics → easiest to keep usage functional.

22

Harm Reduction / Re: Save your dope/cash/life ==> timesafe Time Delay Safes

« Last post by Chip on November 07, 2025, 09:09:48 AM »

Mate needed to break in so I ordered a metal one this time !

Hint: Never get a plastic one and throw away your hacksaw ...

Here is the new one in operation:

23

Heroin / Re: Little Criminals - a graphic video on the Heroin lifestyle circa 1999 in UK

« Last post by smfadmin on November 07, 2025, 01:02:28 AM »

Related video: Detox or Die 2004

About Ibogaine treatment for the producer of the above video ...

https://vimeo.com/25291673?&login=true#_=_

24

Heroin / Little Criminals - a graphic video on the Heroin lifestyle circa 1999 in UK

« Last post by Chip on November 07, 2025, 12:51:11 AM »

Warning: Prolific IV use and possibly triggering

i=JKOMe3VHyai-Z7-e

25

Neuroscience / Excitatory Neurotransmitters: Dopamine's Dual Role in Brain Function

« Last post by Chip on November 01, 2025, 03:10:48 AM »

A good read:

https://neurolaunch.com/excitatory-neurotransmitters/

Excitatory Neurotransmitters: Dopamine's Dual Role in Brain Function

Intro:

Neurotransmitters play a crucial role in brain function, acting as chemical messengers that facilitate communication between neurons. These molecules are essential for various cognitive processes, emotional regulation, and physiological functions. Among the many neurotransmitters in the brain, dopamine stands out as a particularly intriguing and complex molecule, with ongoing debates about its classification as an excitatory or inhibitory neurotransmitter.

To understand the unique nature of dopamine, it’s important to first grasp the concept of excitatory and inhibitory neurotransmitters. Excitatory neurotransmitters are chemicals that increase the likelihood of a neuron firing an action potential, essentially stimulating neural activity. On the other hand, inhibitory neurotransmitters decrease the probability of neuronal firing, effectively dampening neural activity. While most neurotransmitters can be clearly categorized as either excitatory or inhibitory, dopamine’s classification is not as straightforward.

Understanding Excitatory Neurotransmitters
Excitatory neurotransmitters are chemical messengers that promote neuronal firing and increase brain activity. When released into the synaptic cleft, these neurotransmitters bind to specific receptors on the postsynaptic neuron, causing a depolarization of the cell membrane. This depolarization increases the likelihood of the neuron generating an action potential, thus propagating the neural signal.

One of the most abundant and well-known excitatory neurotransmitters in the brain is glutamate. Glutamate plays a crucial role in various cognitive functions, including learning and memory formation. It is essential for synaptic plasticity, the ability of synapses to strengthen or weaken over time in response to increased or decreased activity. Dopamine, Norepinephrine, and Acetylcholine: Key Neurotransmitters in Brain Function are also important excitatory neurotransmitters, each with unique roles in brain function.

Norepinephrine, another excitatory neurotransmitter, is involved in arousal, attention, and the fight-or-flight response. It helps regulate mood, sleep patterns, and cognitive functions such as memory and focus. Acetylcholine, while primarily known for its role in muscle contraction, also acts as an excitatory neurotransmitter in the central nervous system, playing a crucial role in attention, learning, and memory.

The impact of excitatory neurotransmitters on brain activity and behavior is profound. They are responsible for enhancing neural signaling, which is essential for various cognitive processes, emotional responses, and motor functions. Excitatory neurotransmitters contribute to the brain’s ability to process information, form memories, and generate appropriate responses to environmental stimuli.

26

Amino Acids and Supplements / Supplements to Counter Methamphetamine Neuroinflammation & Neurotoxicity

« Last post by smfadmin on November 01, 2025, 01:15:46 AM »

Built by ChatGPT (GPT-5)

Supplements to Counter Methamphetamine Neuroinflammation & Neurotoxicity

Evidence-based harm reduction guide

Last Updated: 2025-10-31 
Focus: Mitigating oxidative stress, neuroinflammation, and dopaminergic depletion caused by methamphetamine exposure. 
Disclaimer: This is not medical advice. Use with caution and clinical awareness.

---

1. Antioxidant & Anti-inflammatory Core

• Alpha Lipoic Acid (ALA) – 300–600 mg/day 
Universal antioxidant; regenerates glutathione and vitamins C/E; crosses the BBB. 
→ Reduces oxidative stress in dopaminergic terminals.

• N-Acetyl Cysteine (NAC) – 600–1200 mg, 2× daily 
Precursor to glutathione; reduces excitotoxicity; blunts MA-induced microglial activation. 
→ Proven to reduce amphetamine-induced neuronal apoptosis in animal models.

• Vitamin C – 500–1000 mg, 2× daily 
Reduces oxidative stress and catecholamine auto-oxidation; supports dopamine synthesis. 
→ Co-administer with zinc for full antioxidant cycle closure.

• Vitamin E (d-α tocopherol) – 200–400 IU/day 
Lipid-phase antioxidant that protects neuronal membranes. 
→ Synergistic with ALA and Vitamin C.

• Curcumin / Turmeric Extract (≥95% curcuminoids) – 500 mg/day 
Anti-inflammatory via NF-κB inhibition and microglial suppression. 
→ Enhances BDNF and reduces MA neuroinflammation markers.

---

2. Mitochondrial & Energy Support

• Acetyl-L-Carnitine (ALCAR) – 500–1000 mg/day 
Improves mitochondrial ATP output and synaptic repair. 
→ Helps restore dopaminergic energy metabolism post-MA.

• Coenzyme Q10 (Ubiquinol) – 100–200 mg/day 
Mitochondrial electron transport cofactor; synergistic with ALCAR. 
→ Reduces MA-induced lipid peroxidation and protects striatal mitochondria.

• Creatine Monohydrate – 3–5 g/day 
Stabilizes ATP levels and phosphocreatine buffer during neural stress. 
→ Shown to reduce dopaminergic neuron loss in oxidative models.

---

3. Neurotransmitter & Synaptic Recovery

• L-Tyrosine – 500–1500 mg/day 
Precursor to dopamine, norepinephrine, and epinephrine. 
→ Replenishes catecholamines post-MA use.

• DL-Phenylalanine (DLPA) – 250–500 mg/day 
D-enantiomer inhibits enkephalinase; L-enantiomer → dopamine precursor. 
→ Supports mood and catecholamine balance.

• Citicoline (CDP-Choline) – 250–500 mg/day 
Boosts membrane phospholipids and acetylcholine; protects dopaminergic terminals. 
→ Enhances synaptic plasticity after stimulant exposure.

• SAM-e – 200–400 mg/day 
Methyl donor for dopamine metabolism and neuronal repair. 
→ Supports monoamine turnover; synergistic with B12 + folate.

---

4. Neuroinflammation Modulators

• Omega-3 Fatty Acids (EPA/DHA) – 1–2 g combined/day 
Anti-inflammatory; regulates microglia and synaptic fluidity. 
→ Restores neuroplasticity and suppresses neuroinflammatory cytokines.

• Palmitoylethanolamide (PEA) – 300–600 mg/day 
Endogenous fatty amide that downregulates mast cell and glial activation. 
→ Strong neuroinflammation modulator with minimal side effects.

• Resveratrol – 200–400 mg/day 
Activates SIRT1 and suppresses microglial NF-κB. 
→ Reduces MA-induced neuronal apoptosis in animal models.

---

5. Sleep & Serotonin System Repair

• 5-HTP – 50–100 mg before bed 
Serotonin precursor; supports post-MA serotonergic recovery. 
→ Use cautiously; avoid within 12 hours of MA to prevent serotonin syndrome.

• Melatonin – 1–5 mg nightly 
Strong antioxidant and circadian regulator. 
→ Reverses MA-induced oxidative stress and sleep disruption.

• Magnesium (glycinate or citrate) – 200–400 mg/day 
NMDA receptor modulator; prevents excitotoxicity. 
→ Restores calm, reduces glutamate overactivity.

---

6. Adjuncts for Vascular & Systemic Protection

• Vitamin D3 – 2000–5000 IU/day 
Anti-inflammatory, supports dopaminergic neurogenesis. 
→ Correlates inversely with stimulant-induced neurotoxicity.

• Zinc – 15–25 mg/day 
Cofactor for dopamine synthesis and antioxidant enzymes. 
→ Prevents catecholamine auto-oxidation damage.

• Iron (if deficient only) 
Required for tyrosine hydroxylase (dopamine synthesis). 
→ Avoid excess; iron overload worsens oxidative stress.

---

7. Stacking Summary

Morning stack: 
ALA + NAC + ALCAR + CoQ10 + Tyrosine + Citicoline + Vitamin C + D3 + Omega-3

Evening stack: 
Curcumin + PEA + Magnesium + Vitamin E + Resveratrol + Melatonin + 5-HTP

---

References & Notes

• PubMed: Methamphetamine-induced neurotoxicity mechanisms (2019–2024)
  
• Antioxidant supplementation in dopaminergic neurodegeneration models
  
• NAC, ALA, and PEA – clinically reviewed neuroprotectants
  
• BDNF and mitochondrial upregulation post-stimulant withdrawal
  

→ Goal: Minimize microglial activation, restore mitochondrial efficiency, and normalize dopamine-serotonin balance.

27

Tryptamines / Re: What's the Deal with DMT Vapes?

« Last post by samueljenkins on October 30, 2025, 07:59:00 PM »

Interesting topic! While discussions around DMT vapes are complex, I’ve been more into exploring safer, legal options like the Geek Bar Vape, which delivers great flavor and performance.

28

Psychology and Psychiatry / Re: Life's Best Tips Of All Time (according to me and Quora)

« Last post by Chip on October 24, 2025, 01:03:18 PM »

When a woman truly loves you, she gives everything , her trust, her heart, and her peace. If you want to keep that love, here are 23 things you should never do:

Don’t break her heart. Love should protect, not wound.

Don’t fake love. If your feelings have changed, be honest , lies leave deeper scars.

Never insult her looks. Every woman wants to feel desired by the man she chose.

Stop comparing her to your ex. Each woman deserves her own story, not someone else’s shadow.

Don’t take her for granted. Attention fades fast when it’s not appreciated.

Don’t yell. If you can’t talk calmly, step away. Anger solves nothing.

Never raise your hand at her. Real men control their temper, not their partner.

Don’t cheat. If loyalty feels like a burden, you shouldn’t be in a relationship.

Don’t disrespect her. Correct in private, praise in public.

Don’t waste her time. If you see no future, end it with honesty, not excuses.

Don’t pressure her for sex. Respect her boundaries , desire without respect is selfishness.

Don’t make her doubt your love. Consistency matters more than big words.

Never force her. Rape is violence, not passion , it kills everything love stands for.

Tell her she’s beautiful. Not just when she’s dressed up, but when she’s tired and real.

Don’t mock her in public. Private jokes are fine , humiliation is not.

Don’t run from responsibility. If she’s pregnant, step up.

Keep her secrets safe. Loyalty isn’t just about bodies , it’s about trust.

Don’t lie. The truth hurts less than being played.

Don’t correct her in front of others. Protect her pride.

Respect her family. You can’t love her while hating where she came from.

Value her presence. She’s not an accessory ,she’s a partner.

Keep your promises. Reliability is rare , be the exception.

Never deceive or use her. Love is not a game; integrity is the test.

When a woman gives her love, it’s not weakness,it’s trust. If you can’t protect that, leave her before you break her.

29

Psychology and Psychiatry / Re: Life's Best Tips Of All Time (according to me and Quora)

« Last post by smfadmin on October 24, 2025, 05:51:11 AM »

Essential Truths of Psychology and Life:

1. Show your true colors from the start. Those who stay are meant to.

2. The less you care, the more others will notice you.

3. Fewer connections mean less unnecessary stress.

4. Once you realize how fast you're forgotten, you'll focus more on yourself.

5. Don't get too comfortable; feelings can change overnight.

6. What people do speaks louder than what they say.

7. Sometimes, breaking down is necessary for growth.

8. Keep your secrets close. Today's friend could be tomorrow's foe.

9. Loyalty should only be given to those who never make you question theirs.

10. People only notice your change, not what caused it.

30

Alcohol & Tobacco / Psychedelic beer may have helped pre-Inca empire in Peru

« Last post by smfadmin on October 09, 2025, 12:45:24 AM »

https://www.livescience.com/archaeology/psychedelic-beer-may-have-helped-pre-inca-empire-in-peru-schmooze-elite-outsiders-and-consolidate-power?utm_medium=referral&utm_source=pushly&utm_campaign=Archaeology

Psychedelic beer may have helped pre-Inca empire in Peru schmooze elite outsiders and consolidate power

Oct 08, 2025

The Wari used beer mixed with psychedelics to help build an empire in Peru around 1,200 years ago, a new study suggests.

The growth of a pre-Inca civilization known as the Wari may have been aided by psychedelic-laced beer, researchers propose in a new study.

The Wari flourished from roughly A.D. 600 to 1000 and are known for their mummified burials, human sacrifices, and elaborate objects created out of gold, silver and bronze.

They also built cities such as Huari and Pikillaqta, which contained temples and dwellings for elite inhabitants, and controlled much of Peru as well as parts of Argentina and Chile.

In the new study, published Monday (Oct. 6) in the journal La Revista de Arqueología Americana (The Journal of American Archaeology), the researchers suggest that Wari rulers used psychedelics mixed in beer to help grow their empire. They explain that the "afterglow" — the long-term effect of drinking the mix — would have lasted weeks and that communal feasts where it was drunk would have brought people together. While the body may excrete psychedelics quickly, the aftereffects can last for days or weeks.

The study authors noted that the remains of seeds from a plant named Anadenanthera colubrina (also known as vilca) have been found at Wari sites, including near the remains of beer made from a plant called Schinus molle. Mixing the vilca, which is known to produce a psychedelic effect, with the beer would have "lessened but extended the high," Justin Jennings, a curator of South American Archaeology at the Royal Ontario Museum and co-author of the paper, told Live Science in an email.

In the paper, the authors noted that scientific studies of similarly acting psychedelics found that people who took them tended to display "greater openness and empathy."

These traits "would have been highly desirable for a Wari political system that depended on friendly, routine face-to-face interactions between people who had once been strangers or even enemies," the researchers wrote in their paper.

People would have drunk the psychedelic beer together at communal feasts held within enclosed areas at the residences of Wari officials. This shared experience would have enhanced the event, the researchers said.

"When guests came to the Wari compounds, they gathered in patios that could only comfortably fit a couple dozen people," the team wrote. "Except for a patch of sky, they were cut off from the rest of the world in a high-walled interior space — this was the place where they would spend hours together drinking, eating, talking, and praying," the researchers wrote in their paper.

"The hours that participants spent together must have been an unforgettable collective experience that forged strong bonds between participants," they added.

Building an empire:

The regular, widespread use of the psychedelic beer and its afterglow played a key role in the Wari Empire's consolidation of political power, said Jacob Keer, an independent scholar and co-author of the paper.

The "long-term psychological effects of drinking vilca beer a few times a year could constitute a new cognitive normal, instilling increased openness and empathy in feast participants," the researchers wrote in their paper. "Within the context of an expanding empire where violence and animosity was commonplace, the lingering effects [of consuming it] may have been integral to Wari legitimization and consolidation."

Scholars who were not involved with the research had mixed reactions to the conclusions in the paper, however. Patrick Ryan Williams, director of the School of Human Evolution and Social Change at Arizona State University, said the team put forward an "interesting hypothesis" but cautioned that we can't be certain that vilca was actually mixed into beer.

"I am not convinced, however, that the discovery of vilca seeds in an area where molle beer was consumed constitutes evidence of vilca being included as an ingredient in beer," Williams said, as it would be like finding cocaine on the floor of a nightclub and assuming the drug was put into drinks.

"When a chemical trace for vilca is found in the ceramic pores of drinking cups, I will be more open to the premise presented here," Williams said.

Mary Glowacki, an archaeologist and president of the Pre-Columbian Archaeological Research Group, called the paper "thought-provoking" but noted that "most early Andean societies used intoxicating substances — including vilca — for political negotiation." She questioned whether the Wari's use of psychedelics was greatly different from that of other groups in the region.

Images:

This jar was found at the Wari site of Conchopata and may have held beer during feasts. (Image credit: José Ochatoma)

Bones, ceramics, botanical remains and other finds from a Wari feast held at the site of Quilcapampa. (Image credit: Lisa Milosavljevic)

If you need any help or a chat then IM/PM or email me, Chip