Supplement Data for Extremely High Dose Methylamphetamine Users

[Chip (OP)]

So, I've been averaging 1750 mg *racemic* MA every two days but I'm on the maximum Clopixol Deconate dose biweekly IM.

I've not slept more than an hour or two, a night for over two weeks and I'm fine.

This is my minimum supplement intake *every few hours when using heavily*, including ratios/counts and doses.

Neuroprotectants, Neurotegeneratives:

* Thiamine 200 per day

* NAC or N-Acetyl-Cysteine 600 mg each 2:2 Resveratrol 1800 mg each

Repletes -- Catecholamines + Serotonin (Melatonin doses are at the users discretion):

* DLPA or DL-Phenylalanine 500 mg each 5:3 L-Tyrosine 500 mg each

* L-Tryptophan 1500 mg each 1:1 5-HTP each

Deamination -- COM2 drivers/Methyl Donorship:

* L-Methionine 500 mg each 3:1 SAMe 400 mg each

GABA vs it's inverted sister, Glutamate complex:

* L-Glutamine 500 mg each 2:2 GABA 750 mg each

AI says:

Your regimen and transparency about publishing harm-reduction data are commendable in that you're promoting an open dialogue on a subject often shrouded in stigma. However, as you pointed out, there are significant risks involved in the practices you’ve described. Here’s an analytical perspective, acknowledging that you're already well-informed but prioritizing safety and clarity:

General Observations:

1. Methylamphetamine Dosage:

A dosage of 1750 mg of racemic methylamphetamine every two days is extreme and carries significant risks of cardiovascular events, neurotoxicity, and long-term physiological damage. Combining this with minimal sleep further exacerbates these risks.



2. Clopixol Decanoate (Zuclopenthixol):

The biweekly IM administration at maximum dosing introduces concerns about extrapyramidal side effects, cognitive dulling, and metabolic stress. This is particularly significant in the context of stimulants.



3. Neuroprotective and Supplement Protocol:

Your supplement list demonstrates a good understanding of potential neuroprotection and neurotransmitter balance. However, the real efficacy of supplements in counteracting the neurotoxic and oxidative damage caused by methylamphetamine is limited, especially at such doses.





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Supplement Analysis:

Neuroprotectants:

Thiamine: Great for supporting glucose metabolism and nerve function, but 200 mg/day is already high; excess might not provide additional benefits.

NAC (600 mg): A well-studied antioxidant. Combining it with resveratrol (1800 mg) may help mitigate oxidative stress, but the effectiveness against methylamphetamine-induced neurotoxicity is uncertain in heavy use.


Catecholamine/Serotonin Repletion:

DLPA/Tyrosine:

Useful in restoring dopamine but could contribute to hyperstimulation in combination with high-dose stimulants.


L-Tryptophan/5-HTP: These promote serotonin synthesis but could pose a risk of serotonin syndrome, particularly in combination with Clopixol, which may have serotonergic activity.


Methylation Support:

Methionine/SAMe:

Essential for detoxification pathways but could lead to over-methylation and exacerbate oxidative stress under such heavy usage.



GABA/Glutamate Balancing:

L-Glutamine/GABA: Balancing excitatory (glutamate) and inhibitory (GABA) systems is critical. However, the efficacy of exogenous GABA supplementation is controversial, as it may not cross the blood-brain barrier effectively.



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Concerns and Recommendations:

1. Sleep Deprivation: The lack of sleep creates a compounded risk to your cardiovascular, metabolic, and immune systems, even if you're "feeling fine." Chronic sleep deprivation can also accelerate neurodegeneration.


2. Long-Term Risks:

Even with neuroprotective measures, high-dose stimulant use poses irreversible risks like cognitive impairment, cardiovascular damage, and emotional dysregulation.



3. Data Publishing: Sharing this protocol could encourage experimentation by others without your level of understanding or physiological resilience, which might inadvertently lead to harm.


4. Suggestions:

Prioritize sleep with targeted interventions such as melatonin or prescription sleep aids (under medical supervision).

Regular cardiovascular check-ups and neuroimaging to monitor for damage.

Gradually reduce stimulant intake while increasing reliance on supplements for recovery rather than sustenance during heavy use.





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Your approach to harm reduction is meticulous, but pushing physiological limits can backfire even with countermeasures. Balancing transparency with safety in your publications is essential to ensure your audience doesn't misinterpret your experience as universally replicable.

Do NOT mimic my seemingly blase approach never, ever bc I'm old and IDGAF much !!!