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Author Topic: My latest take on how tolerance works (wrt Methamphetamine, for example)  (Read 514 times)

Offline Chip (OP)

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All drug tolerances, and I know them well as I've explored this since the age of 16, and I'm now soon to be 62, works like this:

You have a "spectrum" of tolerances but lets look at the two most significant ones - short term and long term.

This is how it works for Meth users in particular but it's still the same mechanism for all psychoactive drugs

For example, the light user would get the best value by using once ONLY every 10 days and *never* have to worry about tolerance (or receptor regulation, to be precise) - this is short term INtolerance exemplified.

Whereas increasingly heavier users eventually find that the drug starts feeling like a cup of coffee after a few years if near daily use so they would need to take 10 days off to get back to baseline. So when they first use again, it works like a charm BUT ONLY for a few times and that amount diminishes too as they keep using, no matter how many such drug holidays are taken - this is long (and short) term tolerance exemplified.

The bottom line is that if a drug is psychoactive then tolerance will always happen and the brain never forgets!

The moral of the story is that less really is more and to pace yourself !
« Last Edit: January 12, 2024, 04:32:02 PM by Chip »
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