7-OH-Mitragynine–Induced Psychosis and Delirium

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https://www.psychiatrist.com/pcc/7-oh-mitragynine-induced-psychosis-delirium/?utm_source=Klaviyo&utm_medium=email&utm_campaign=FOM_New_4%2F17&klid=01HYSTTNXNB74YAYKT9XMYQCN0&_kx=va3uRF3O8-7Dg_zjrKMZJk0wdery-TOTVyZ3l8muM1g.VpkqxC

7-OH-Mitragynine–Induced Psychosis and Delirium

April 14, 2026

Mitragyna speciosa is a tropical tree native to Southeast Asia, the leaves of which are commonly known as kratom. 7-Hydroxymitragynine (7-OH) is a substance derived from kratom leaves and is marketed as a distinct product.

Although its full properties are poorly understood, 7-OH’s known opioid-like effects and unregulated status in the United States have resulted in more widespread recreational use.

As 7-OH use gains prevalence, it becomes increasingly important to understand its constellation of adverse effects. We present the case of a patient who, following several months of heavy 7-OH use, developed psychosis and delirium that persisted for nearly a week following cessation.

The patient was medically hospitalized and required several days of opioid withdrawal management and supportive care before returning to his baseline mental status.

The case report can be found at the link above ...