Simple amino acid supplement greatly reduces Alzheimer’s damage

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Simple amino acid supplement greatly reduces Alzheimer’s damage | ScienceDaily

https://www.sciencedaily.com/releases/2025/11/251121090731.htm

November 21, 2025

Arginine shows unexpected power to reduce amyloid damage, hinting at a low-cost, fast-track Alzheimer’s treatment option.

Summary:

Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and improved behavior. Its strong safety record and low cost make it a promising repurposing candidate. The findings hint at a surprisingly simple path toward more accessible AD therapies.

Alzheimer's disease (AD) is a progressive disorder that damages nerve cells in the brain and is one of the main causes of dementia around the world. Current treatments cannot cure the condition. Although antibody-based drugs targeting amyloid β (Aβ) have recently become available, their benefits remain modest. These therapies can also be expensive and may trigger immune-related side effects, underscoring the need for safer, low-cost options that are easier for patients to access.

A new study published in Neurochemistry International reports that researchers from Kindai University and partner institutions found that oral arginine, a naturally occurring amino acid that acts as a safe chemical chaperone, can markedly reduce Aβ aggregation and its toxic effects in animal models of AD. The team noted that although arginine is sold as a dietary supplement, the dose and schedule used in their experiments were designed for research and do not match commercial products.

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An inexpensive amino acid already used clinically—can dramatically reduce amyloid buildup and toxicity in Alzheimer’s models. Credit: Shutterstock