The fact that you found Methylamphetamine in my system is not conclusive as it had zero affect on me, so I need to know more about what tests you ran, if it may not displease the court.
1. What are the chiral (or the 3-D trajectories of the molecule) properties of the methylamphetamine molecule ? S(+)-inister or R(-)-ectus) ?
2. What are the 2-D isomers or enantiomers of its primary planar metabolite, Amphetamine (left/Laevorotatory or right/Dexrorotatory) ?
3. Upon what ring position was the methyl group (see below) connected to ?
4. If you comprehend that my reward system and its metabolic pathways and the location of its neural pathways are all reflected in my DNA, especially after 45+ years of (double) methylation of my phenethylamines ?
So if I don't have my daily dose then I'm absolutely miserable, listless, lethargic, sad, cannot concentrate nor focus and I am very agitated.
5. What was the exact dose ?
6. Why was it paedophile purple ?
7. If you can understand that I was at the end of my tether, shut out from everywhere so I had had ENOUGH ! - I was in a hurry because I wanted to kill my dealer, lol, complete with HIV-infected needle then save him with PrEP ! That sort of ideation, although not serious, indicates how angry I was !
8. If you convict me then I'll withdraw my support, ideas and designs.
9. Did you take my tolerance of 46+ years into account ?
10. Other countries at least a blood/drug threshold and so should Australia.
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20 years of sexual abuse by proxy - the WIGGLER (at home, at the dealers), rumours and perpetual rip-offs !
Let's use AI to look at just the homologous aromatic hydrocarbon benzene ring positions:
The psychoactivity of ring-substituted amphetamines (methylamphetamine derivatives with substitutions at positions 3, 4, 5, or 6 of the aromatic ring) depends on the nature of the substitution and the position. These compounds are part of a broader class called substituted amphetamines, which exhibit diverse effects ranging from stimulatory to hallucinogenic depending on the modification. Here's a breakdown:
Ring Positions and Psychoactivity
1. Position 3 (Meta position)
Substituents on the 3-position can alter the compound's interaction with monoamine transporters, especially dopamine, norepinephrine, and serotonin.
Examples:
3,4-Methylenedioxyamphetamine (MDA) is highly psychoactive and produces empathogenic and hallucinogenic effects.
Substitutions at position 3 alone (without other modifications) are relatively less common in psychoactive derivatives.
2. Position 4 (Para position)
The para position (4-position) is highly significant in determining psychoactivity.
Examples:
4-Methylamphetamine: Has stimulant properties, similar to amphetamine but less potent.
4-Chloroamphetamine: Neurotoxic but psychoactive, influencing serotonin release.
4-Hydroxyamphetamine: A metabolite of amphetamine with minor stimulant activity.
4-Substitutions often increase selectivity for serotonin systems, especially when combined with other functional groups, leading to MDMA-like empathogenic effects.
3. Position 5 (Meta position)
Substitutions at the 5-position are less common and often decrease psychoactivity relative to 3 or 4.
Example:
5-Methylamphetamine has reduced psychoactivity compared to 4-methylamphetamine.
4. Position 6 (Ortho position)
Substitutions at the 6-position tend to disrupt interaction with monoamine transporters and often result in reduced or no psychoactivity.
These modifications are rare in recreational or pharmaceutical contexts.
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General Trends
Substitutions at position 4 (para) tend to be the most psychoactive due to favorable interactions with neurotransmitter systems.
Substitutions at positions 3 and 5 can also be psychoactive, but the effects are typically weaker or more variable.
Substitutions at position 6 (ortho) often diminish psychoactivity.
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Nature of Substituents
The psychoactivity also depends on the chemical nature of the substituent:
Hydroxy (-OH): May reduce lipophilicity, altering blood-brain barrier permeability but can result in active metabolites (e.g., 4-hydroxyamphetamine).
Methoxy (-OCH3): Often enhances hallucinogenic properties (e.g., 3,4-methylenedioxy derivatives).
Halogens (Cl, Br, F): Para-halogenated compounds (e.g., 4-chloroamphetamine) often affect serotonin systems and may have neurotoxic potential.
Alkyl groups (-CH3, -CH2CH3): Typically enhance stimulant properties (e.g., 4-methylamphetamine).
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Conclusion
Position 4 (para) is most significant for psychoactivity in terms of both potency and variety of effects (stimulant, empathogenic, or hallucinogenic).
Position 3 and 5 modifications may also be psychoactive but are usually less potent or selective.
Position 6 substitutions are generally non-psychoactive or minimally psychoactive.
Would you like details about specific compounds or the pharmacology of certain substitutions?
In the context of substituted amphetamines, positions 1 and 2 refer to the side chain carbons of the amphetamine molecule (rather than the aromatic ring). Substitutions at these positions can have significant effects on the compound's psychoactivity, metabolism, and overall pharmacological profile. Here's a detailed breakdown:
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Position 1 (α-Carbon)
The α-carbon (adjacent to the amine group) is a key site for substitution.
Changes here strongly influence the compound's pharmacokinetics (absorption, metabolism) and pharmacodynamics (interaction with monoamine systems).
Common Substitutions:
1. Methyl group (-CH3)
Adding a methyl group at the α-carbon produces methamphetamine.
Methamphetamine is significantly more psychoactive than amphetamine due to increased lipophilicity, better blood-brain barrier penetration, and greater resistance to metabolism.
Effects: Potent central nervous system (CNS) stimulant with strong dopamine-releasing properties.
2. Ethyl group (-CH2CH3)
Substitution with a larger group (e.g., ethyl) tends to reduce psychoactivity.
Example: Ethylamphetamine is less potent than amphetamine and has weaker stimulant effects.
3. Hydroxyl group (-OH)
This substitution, found in ephedrine and pseudoephedrine, significantly reduces CNS psychoactivity. Instead, the compound acts more on peripheral adrenergic receptors, making it a mild stimulant.
4. Halogens or bulky groups
Large or electronegative substitutions generally reduce psychoactivity, often rendering the compound inactive as a stimulant.
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Position 2 (β-Carbon)
The β-carbon (next to the α-carbon, farther from the amine group) is another site of modification.
Substitutions here affect interaction with monoamine transporters and enzymes like monoamine oxidase (MAO), influencing the compound's psychoactivity and metabolism.
Common Substitutions:
1. Hydroxyl group (-OH)
The addition of a hydroxyl group here results in phenylpropanolamine (PPA) or norephedrine. These compounds have little to no psychoactivity but retain peripheral stimulant properties (used in decongestants).
This substitution increases polarity, reducing brain penetration and psychoactivity.
2. Ketone group (=O)
Substitution with a ketone group at the β-carbon forms cathinone, the active compound in the khat plant.
Cathinones are stimulants with amphetamine-like properties but are less potent.
Methcathinone (β-keto methamphetamine) is a designer drug with stimulant effects similar to methamphetamine.
3. Halogens or other bulky groups
Modifications at the β-carbon with bulky or electronegative groups often reduce CNS activity.
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General Trends
Position 1 (α-carbon):
Substitutions at the α-carbon (especially small alkyl groups like methyl) significantly enhance psychoactivity by increasing dopamine-releasing properties and brain penetration. Larger groups tend to reduce psychoactivity.
Position 2 (β-carbon):
Substitutions here often diminish psychoactivity, especially polar groups (e.g., hydroxyl or ketone), which reduce the compound's ability to cross the blood-brain barrier. However, some β-carbon substitutions like ketones (e.g., cathinones) retain stimulant properties.
Summary
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Position 1 (α-carbon): Affects potency, stimulant effects, and CNS activity. Methylation (e.g., methamphetamine) enhances psychoactivity.
Position 2 (β-carbon): Substitutions typically reduce psychoactivity but may retain peripheral stimulant effects. Ketones (e.g., cathinones) are an exception, maintaining moderate stimulant properties.
September 02, 2015, 10:36:10 PM
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