MND Stem Cell Update

[Chip (OP)]

Addendum:

The regrowth of pyramidal motor neurons and interneurons using stem cells holds significant promise for stimulating motor neuron traffic and potentially treating various neurological conditions.

Recent studies have shown that human induced pluripotent stem cells (iPSCs) can be differentiated into pyramidal neuronal precursors (PNPs).

These PNPs, when transplanted into models of spinal cord injury, have demonstrated the ability to mature into corticospinal pyramidal neurons and extend axons into host spinal cord tissues¹.

* This not only helps in reconstructing neuronal circuits but also shows potential in modulating the microenvironment to support nerve regeneration¹.

Moreover, the human motor cortex microcircuit, which includes pyramidal neurons and interneurons, plays a crucial role in motor functions.

Understanding and leveraging this microcircuit can provide insights into neurodegenerative diseases and help develop targeted therapies².

It's an exciting area of research with the potential to make significant strides in treating conditions like spinal cord injuries, ALS, and other neurodegenerative diseases.

 Are you interested in any specific applications or recent advancements in this field?

Source: Conversation with Copilot, 2024-10-04

(1) Human induced pluripotent stem cell/embryonic stem cell-derived .... https://link.springer.com/article/10.1007/s00018-024-05350-9.

(2) The human motor cortex microcircuit: insights for ... - Nature. .

(3) A shared origin for cortical excitatory neurons and interneurons - Nature.

https://www.nature.com/articles/d41586-021-03664-3.

(4) Pluripotent stem cell strategies for rebuilding the human brain.

* https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.1017299/full.

(5) undefined. https://doi.org/10.1038/.