Users with PD: The genetic epidemiology of personality disorders

[Chip (OP)]

source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181941/

Some (many) of us have personality disorders and frequently we self-prescribe drugs that our doctors won't.

People with PD's often engage in substance abuse as a way to self-medicate or alleviate feelings of anxiety and depression.

(genotypes^Wiki and phenotypes^Wiki)

an excerpt:

Common genetic and environmental liability factors contribute to comorbidity between pairs or clusters of axis I and axis II disorders. Molecular genetic studies of personality disorders (PDs), mostly candidate gene association studies, indicate that genes linked to neurotransmitter pathways, especially in the serotonergic and dopaminergic systems, are involved. Future studies, using newer methods like genome-wide association, might take advantage of the use of endophenotypes^Wiki.