Ranked Street Substances by Combined Psychoactivity & Addictiveness

[Chip (OP)]

💊 Ranked Street Substances by Combined Psychoactivity & Addictiveness

Rank	Substance	Psychoactivity	Addiction Risk	Combined	Notes
1	Carfentanil	10	Extreme	14	Extremely potent synthetic opioid (100x Fentanyl)
2	Fentanyl	9.5	Extreme	13.5	Ultra-potent synthetic opioid
3	Nitazenes (e.g., Isotonitazene)	9.4	Extreme	13.4	New ultra-potent opioid class, stronger than fentanyl
4	Heroin	9	High	12	Semi-synthetic opioid; strong euphoria and sedation
5	Methamphetamine	9	High	12	Potent central stimulant, long-acting
6	Crack Cocaine	8.5	High	11.5	Smoked freebase form; intense, short-lived high
7	Cocaine	8	High	11	Stimulant; short duration; strong DA/NE reuptake inhibition
8	PCP	8	Moderate	10	NMDA antagonist; dissociative and deliriant effects
9	Ketamine	7.5	Moderate	9.5	Dissociative anesthetic; NMDA antagonist
10	MXE	7.4	Moderate	9.4	Longer-acting ketamine analog; dissociative
11	MDMA (Ecstasy)	7	Moderate	9	Empathogen; serotonin and dopamine releaser
12	Spice/K2 (Synthetic Cannabinoids)	6	High	9	Unpredictable synthetic cannabinoids
13	LSD	7.8	Low	8.8	Classic serotonergic psychedelic
14	DMT	7.7	Low	8.7	Ultra-short-acting intense psychedelic
15	5-MeO-DMT	7.6	Low	8.6	Non-visual, ego-dissolving psychedelic
16	NBOMe compounds	6.5	Moderate	8.5	Highly potent 5-HT2A agonists
17	Alcohol	5.5	High	8.5	GABAergic CNS depressant
18	Psilocybin Mushrooms	7.3	Low	8.3	Serotonergic tryptamine psychedelic
19	Toluene (Inhalant)	5.2	High	8.2	Solvent with disorienting CNS effects
20	Marijuana (High-THC strains)	6	Moderate	8	Cannabinoid agonist; euphoria + relaxation
21	2C-B	6.8	Low	7.8	Psychedelic phenethylamine; visual + empathogenic
22	Mescaline (Peyote/San Pedro)	6.7	Low	7.7	Natural psychedelic phenethylamine
23	Benzodiazepines (e.g. Xanax, Valium)	4.5	High	7.5	GABA-A agonists; anxiolytic/sedative
24	Ayahuasca	6.3	Low	7.3	Oral DMT + MAOI brew
25	Salvia divinorum	6.2	Low	7.2	Kappa-opioid agonist; intense short hallucinations
26	Barbiturates	4.2	High	7.2	GABA-A potentiators; older sedatives
27	DXM (in high doses)	5	Moderate	7	OTC NMDA antagonist/dissociative
28	Nitrous Oxide	5.4	Low	6.4	Dissociative gas; NMDA antagonist
29	Codeine	4	Moderate	6	Weak opioid; often combined with paracetamol
30	Kratom	4	Moderate	6	Mitragynine; mild opioid agonist/stimulant hybrid
31	Tobacco (Nicotine)	3	High	6	Stimulant and neuromuscular modulator
32	Zuclopenthixol	3.8	Low	4.8	Notazine antipsychotic; strong D2 blocker
33	Flupenthixol	3.7	Low	4.7	Motivational lift + antipsychotic effects
34	Clopenthixol	3.6	Low	4.6	Sedative Notazine; rarely used recreationally
35	Haloperidol	3.5	Low	4.5	Potent typical antipsychotic; tranquilizer effect
36	Olanzapine	3.4	Low	4.4	Atypical antipsychotic; heavy sedation in high doses
37	Caffeine	2	Moderate	4	Adenosine receptor antagonist; mild stimulant