AI on Neurotransmitter Optimum Replete Ratios for Methylamphetamine

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Merry Christmas ! I have a "replete question":

1. What ratio of DL-Phenylalanine/L-Tyrosine to L-Tryptophan/5-HTP precursors should I be taking (milligrams) to replete the Catecholamines and Serotonin that Methylamphetamine uses, for optimum neurotransmitter health ?

This is an important and complex question, so let’s break it down carefully.

The ratio and dosages of DL-Phenylalanine/L-Tyrosine to L-Tryptophan/5-HTP depend on your specific goals, body chemistry, and the extent of neurotransmitter depletion caused by methylamphetamine use.

Here’s a general guideline based on common neurochemical principles:

1. Catecholamines (Dopamine, Norepinephrine, Epinephrine)

Precursor: DL-Phenylalanine (DLPA) or L-Tyrosine

Typical dosage: 500–2000 mg per day, split into 1-3 doses

These precursors replenish dopamine and norepinephrine stores, which are heavily depleted by methylamphetamine use.

L-Tyrosine is more direct, but DLPA also supports mood and pain modulation.

2. Serotonin

Precursor: L-Tryptophan or 5-HTP

● Typical dosage:

L-Tryptophan: 500–1500 mg per day

5-HTP: 50–200 mg per day

5-HTP bypasses the rate-limiting step (conversion of tryptophan to 5-HTP), so smaller doses are often sufficient. It also has faster action.

3. Optimal Ratio for Balance

A commonly suggested ratio is approximately 10:1 to 15:1 of DL-Phenylalanine/L-Tyrosine to L-Tryptophan/5-HTP.

Example:

DLPA/L-Tyrosine: 1000–1500 mg

L-Tryptophan/5-HTP: 100–150 mg

This ratio ensures that catecholamines (dopamine and norepinephrine) are prioritized without overly stimulating serotonin, which can lead to imbalances or adverse effects like fatigue or irritability.

4. Timing and Synergy

DLPA/L-Tyrosine:

Take in the morning or early afternoon (away from meals) to avoid disrupting sleep.

L-Tryptophan/5-HTP:

Take in the evening or before bedtime to support serotonin and melatonin synthesis, aiding restful sleep.

5. Cautions and Adjustments

Methylamphetamine Use: Consult a healthcare professional, as your brain's baseline levels may significantly deviate from the norm.

Supplementation should be part of a broader neurochemical support plan, including proper nutrition, hydration, and sleep.

B6 and Cofactors: Ensure adequate Vitamin B6, Magnesium, and Zinc intake, as these are vital cofactors for neurotransmitter synthesis.

Start Low, Go Slow: Individual sensitivity varies. Begin with lower doses and adjust as needed.

Anyway, the optimal ratio of DL-Phenylalanine/L-Tyrosine to L-Tryptophan/5-HTP is approximately 10:1 to 15:1.