Hamilton's Pharmacopeia - Bufo The Psychedelic Toad [x-DMT]

[Chip (OP)]

We are under attack from Cane Toads in AUS and it's a massive problem 'coz those buggers are robust as fuck (just what the Peptide enthusiasts and Immunologists need) ... a little gene editing or cross breeding and the country would start lovin' the Toad, whilst TriPpIn' and wiping out Immunodeficiency Virus.

Now THAT's a sweet "druggie experience" !! I must have a word with the city zoo ☻.

Toads are still legal, i reckon.
EDIT: Not in the USA so maybe same for Oz.

For research purposes but maybe someone else is interested ...


(2005 - Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells)

https://www.ncbi.nlm.nih.gov/m/pubmed/16140737/

[bignasty]

never seen that episode and I thought I've seen all of them. Looks scary but interesting. I wonder if taking a large dose of benzo's would take away from the effect 'cause I'd be nervous and it'd end up giving me a bad trip if I didn't take enough benzo's beforehand. I wish I had a strong enough mind to like psychedelics without benzo's but that's something I could never do.

[MoeMentim]

real psychedelics are always scary.  i don't treat them like other drugs at all.  i'm very intentional in my use.  i prefer doing them alone but with dmt i like to have a sitter.  never really needed one but the fact that he's there in his right mind is comforting

[bignasty]

real psychedelics are always scary.  i don't treat them like other drugs at all.  i'm very intentional in my use.  i prefer doing them alone but with dmt i like to have a sitter.  never really needed one but the fact that he's there in his right mind is comforting

I'd have to have a hot female sitter that I trusted and was in her right mind as weed used to freak me out so I can't imagine what psychedelics would do to me.

[Chip (OP)]

One day, these drugs will be "tools" for humanity but for some stoopid fucking reason, they are "bad for you" and only in the realm of the deviant ! ... [but never be blase and do your due diligence]

DMT is fine but this is actually something a little different to what I thought.

5-Meo-DMT^Wiki ... and tripsit.me

Bufo alvarius is unique within the genus in its possession of an unusual enzyme (or catalyst), O-methyl transferase, which, among other reactions, converts bufotenine (5-OH-DMT) to the potent hallucinogen 5-methoxy-N,N-dimethyl-tryptamine (5-MeO-DMT).

In fact, the activity of this enzyme leads to the production and accumula- tion of enormous amounts of 5-MeO-DMT, up to as much as 15% of the dry weight of the parotoid and tibia1 glands (Erspamer et al., 1965, 1967; Cei et al., 1972)

[MoeMentim]

the lower colorado river toad excretes dmt as well.  always wanted one of those

[bignasty]

the lower colorado river toad excretes dmt as well.  always wanted one of those

I searched around the internet and I think they're the same thing but folks are giving them different names or different species because they both are supposedly also called the Sonoran toad or Sonoran frog. The lower Colorado river frog isn't Bufo alvarius according to wiki but it says it's the Sonoran toad. Sounds like 2 different species that are similar but people are getting confused about or just using them interchangeably.

[Tainted]

As far as DMT goes, I've read reports on I believe shroomery of people letting their parents (good health, in their  70s) give DMT a try, and it caused them to have a stroke. DMT increases your bloodpressure and heart rate, so it's certainly possible. This was a single ancedotal story, but I've no reason to doubt it's validity, especially given the persons age. They recovered, but it's still something to consider. With that said, I don't believe any species of toad produces DMT. They produce 5-meo-DMT which is completely different than N,N Dimethyltryptamine. To my knowledge, the only sources of DMT are various root barks (acaia confuisous [sp] Mimosa Hostilis and possibly a few others.) I've read that it's produced in certain grasses and in certain mammals, but the levels are not high enough for an extraction.

I watched that episode of hamiltons pharmacopia (I've been a fan of Hamilton Morris since the early 2000's when he was putting out documentaries on the internet about psychedelics) and it honestly turned me off 5-meo-dmt. Taking benzos with it would likely not be a good idea. benzos are known for significantly reducing the effects of tryptamine hallucinogens.

It does seem to depend on the benzo though. I can take 2mg of kpin and my normal dose of LSD an hour or two later and trip with slightly reduced visuals/effects/body load. However, if I take 1mg of xanax 3 hours before I take triple my normal dose, I might get some slight visual distortions, but I don't really trip at all, and I'm able to goto sleep 3 hours into the trip. So clearly there is a difference between benzos. If I'm 5 hours into a trip and getting bored and wanting to goto bed somewhat soon, I can take 2mg of xanax and within 30 minutes, most of the visual effects subside, the closed eye visuals become much less colorful and plentiful, pretty much kills 80% of the trip. Taking the same dose of kpin often doesn't effect the trip much outside reducing the body load. That's been my experience anyways.

[Chip (OP)]

You will need a potent benzo with active metabolites such as Diazepam to offset the serotonergic agent (LSD).

Fuck i could do with a decent trip.

[Tainted]

You will need a potent benzo with active metabolites such as Diazepam to offset the serotonergic agent (LSD).

Fuck i could do with a decent trip.

I guess I've had different results with benzos. I'm prescribed 1mg kpin and 2mg football a day, but i abstain for 36 hours before tripping. If i don't take a big dose (a strip) , and i take either 1mg kpin or xanax, pretty much all the physical effects are gone in 45
Minutes. The visuals are still present but they go from colors blending light warping to just residual tracers and patterning. I took a ten strip at ten last night and took a kpin at like 3am which killed the remainder of the trip. Was hoping to get some sleep but o have yo be up to go-to the clinic in like 2 hours so that's not likely

[Chip (OP)]

well, I finally watched the whole thing.

Hamilton's response to the trip tells all; he is, without doubt, the coolest and most loving tripper I have had the privilege to observe.

his heart and mind know of little, if any, bounds

 

[Tainted]

well, I finally watched the whole thing.

Hamilton's response to the trip tells all; he is, without doubt, the coolest and most loving tripper I have had the privilege to observe.

his heart and mind know of little, if any, bounds

 

It's one of the rare episodes he actually partakes. I've watched every episode of that show cause that dudes awesome, but i only remember him partaking in kratom, 5meoDMT and peyote (he was at a legal native American retreat for peyote) I get the feeling he's not allowed to break the law on the show. There is an episode titled Wizards of DMT where he interviewed two people who outright synthesis it from scratch and one person who provides dmt experiences for people, but he didn't join in, which surprised me.

[Chip (OP)]

Don't forget that he can snyth this stuff in his lab if he wanted to BUT he is into the rich folklore and even the religious aspects of these chemicals that have been used for 100,s and even 1000,s of years by indigenous cultures.

He may have felt that he couldn't truly join in their ceremony for personal reasons or wanted to remain sober for another reason.

You can tell that he has tripped a few times;so that much that his intracranial communications have already neuroplasticized so he
doesn't have the motorneuron overload and can purely enjoy those temporary connections and go even DEEPER.

But most importantly, he loves and seriously respects being allowed to partake in these previously unexposed rituals.

Love is what he finds, love is what he experiences ... nirvana found !