I found an anecdotal story of a woman who took Spironolactone
for adult onset acne.
She found that it greatly reduced her tolerance. (Got high on less)
It also reduced WD symptoms.
It seems to be a little used drug.
I thought it was interesting for a number of reasons.
Link is below:
https://drugs-forum.com/forum/showthread.php?t=283128 From story : " A previously small dose can bring on the nod."
" Spironolactone during opiate withdrawals significantly reduced my symptoms."
"WARNING: Nontoxic doses of spironolactone raised the sensitivity of morphine-tolerant rats so that previously tolerated morphine doses become lethal.
"