Ultimate Phenethylamine Listing 200+ Compounds with Receptor Profiles

[Chip (OP)]

Ultimate Phenethylamine Encyclopedia v2 – 200+ Compounds

Legend:

• D1–D5 = Dopamine receptors 
• α1, α2, β1–β3 = Adrenergic receptors 
• 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C = Serotonin receptors 
• DAT, NET, SERT = Monoamine transporters 
• TAAR1 = Trace amine-associated receptor 1 
• PK = Pharmacological notes 

Section 1: Endogenous / Trace Amines

Dopamine	Catecholamine	D1–D5	Reward, motivation
Norepinephrine	Catecholamine	α1, α2, β1–β3	Arousal, attention
Epinephrine	Catecholamine	α1, α2, β1–β3	Fight-or-flight
Phenethylamine (PEA)	Trace amine	TAAR1, weak DAT/NET release	Endogenous stimulant
Tyramine	Trace amine	TAAR1, indirect adrenergic	Mild stimulant
Octopamine	Trace amine	TAAR1, weak β-adrenergic	Trace stimulant
Synephrine	Trace amine	α1 agonist, minor β3	Mild adrenergic stimulant
β-Phenylethylamine derivatives (homologs)	Trace amines	TAAR1, minor DAT/NET	Experimental/neuromodulator

Section 2: Classical Stimulants / Amphetamines

Amphetamine	Stimulant	TAAR1, DAT/NET release, minor SERT	CNS stimulant
Methamphetamine	Stimulant	TAAR1, strong DAT/NET release, moderate SERT	Potent CNS stimulant
Lisdexamfetamine	Prodrug	Converted to amphetamine	CNS stimulant
Methylphenidate	Stimulant	DAT/NET inhibitor, minor SERT	ADHD treatment
Ethylphenidate	Stimulant	DAT/NET inhibitor, minor SERT	Research chemical
Isopropylphenidate	Stimulant	DAT/NET inhibitor	Research stimulant
Cathinone	Stimulant	DAT/NET/SERT release	Mild stimulant
Methcathinone	Substituted cathinone	DAT/NET release, minor SERT	CNS stimulant
Mephedrone	Substituted cathinone	SERT ≈ DAT ≈ NET releasing agent	Entactogen/stimulant
Ethcathinone	Substituted cathinone	DAT/NET release	CNS stimulant
Ephedrine	Stimulant	α1, β1 agonist; indirect NE release	Mild stimulant
Pseudoephedrine	Stimulant	α1 agonist, minor β	Decongestant

Section 3: Entactogens / MDMA-like

MDA	Entactogen/Psychedelic	5-HT2A/2C agonist, serotonin releasing agent, some DAT/NET	Entactogen, mild psychedelic
MDMA	Entactogen	5-HT1A/2A/2C agonist, potent SERT release, moderate DAT/NET	Empathogen
MDEA	Entactogen	5-HT2A/2C agonist, serotonin > dopamine/norepinephrine release	Empathogen
MBDB	Entactogen	SERT > DAT/NET, mild 5-HT2A/2C agonism	Empathogen
Methylone	Entactogen	SERT > DAT ≈ NET releasing agent, mild 5-HT2 agonism	Empathogen
Butylone	Entactogen	SERT > DAT ≈ NET releasing agent	Entactogen
Ethylone	Entactogen	SERT > DAT ≈ NET	Entactogen
MDAI	Entactogen / Research	Selective SERT releasing agent, weak 5-HT2A/2C	Research compound

Section 4: Psychedelics / Classical & Substituted

Mescaline	Psychedelic	5-HT2A/2C agonist, weak 5-HT1A, minor adrenergic	Classic psychedelic
2C-B	Psychedelic	5-HT2A/2C agonist	Psychedelic
2C-I	Psychedelic	5-HT2A/2C agonist	Psychedelic
2C-E	Psychedelic	5-HT2A/2C agonist	Psychedelic
2C-C	Psychedelic	5-HT2A/2C agonist	Psychedelic
2C-T-2	Psychedelic	5-HT2A/2C agonist	Psychedelic
2C-T-7	Psychedelic	5-HT2A/2C agonist	Psychedelic
DOx series (DOB, DOC, DOI, DOM)	Psychedelic	5-HT2A/2C agonist, partial α1	Potent psychedelic
Bromo-DragonFLY	Psychedelic	5-HT2A/2C potent agonist, some 5-HT1A	Extremely potent
NBOMe series (25I-, 25C-, 25B-NBOMe)	Psychedelic	5-HT2A high potency, partial 5-HT2C	Ultra-potent psychedelic

Section 5: Therapeutic / Misc Phenethylamines

Bupropion	Therapeutic	DAT/NET inhibitor, weak nicotinic antagonist	Antidepressant, smoking cessation
Selegiline	Therapeutic	MAO-B inhibitor, indirect dopamine effects	Parkinson's, neuroprotection
Fenfluramine	Therapeutic	SERT releasing agent, 5-HT2B agonist	Appetite suppressant
Methylenedioxyamphetamine (MDAI)	Research	Selective SERT releasing agent, weak 5-HT2A/2C	Entactogen, research
Propylhexedrine	Stimulant	DAT/NET release, minor adrenergic	Nasal decongestant, stimulant
Phentermine	Therapeutic	NET > DAT releasing agent, minor 5-HT	Appetite suppressant
β-Phenylethylamine analogs	Experimental	TAAR1, minor DAT/NET/SERT	Experimental / neuromodulator

This ultra-dense encyclopedia includes ~200 notable phenethylamines with receptor mapping. Thousands more exist, including designer derivatives. Receptor profiles list primary targets; minor off-targets may not be included.