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41
Deep Learning / -
« Last post by Cliftonpleme on June 01, 2025, 12:19:32 PM »
An interesting or I thought interesting question came up during a discussion with a couple of my good friends.

While discussing Calvinism, Armenianism and Open Theism one of us asked if God can change the past? Now the context is that I am Armenian, but do lean towards Open theism. My one friend is soundly in the middle and the other is Armenian, but leans pretty well to the Calvinist position in many ways.

So one asked if God can change the past. I had been arguing the Open position that God cannot "know" the actual future because it doesnt exist. Time is not a literal, tangible contruct. It isnt a linear "string" with any actual points on it that can be visited. So, according to the Open Theism position, God knows every possible outcome and every possible consequence of every possible choice we can make in every situation...but cannot know the actual choice itself that we will make because until it is made...it has not happened. There IS no future yet that can be known. The lone exception, as any Open theist would readily admit, is in the instances of actual prophecy where God essentially just asserts His absolute will and demands an outcome.

While my one friend was disagreeing, the other asked "can God change the past". His point was that if we come to the conclusion that God cannot change the past because there actually IS NO past to change, then how can we then say God can know the actual choice we will make, and therefore know the actual future and not just every potential future. If the past is not tangible in a sense, like a point on a string behind us, then why do so many assume the future is tangible in a sense? If the string behind us doesnt really exist, then why do we assume the string in front of us does?

It mostly would make time merely a series of "now" where the past and future are NOT actually places but merely constructs of our memory and recorded history. You wuldnt be able to go back to yesterday because yesterday doesnt actually exist. All yesterday is is a series of moments that we lived and happen to remember. It cannot be gone to becuase it never really was a place.

So if that summation is incorrect in your opinion, then can God actually change the past? Can God go back to yesterday and change what you were eating or dinner? Or if a loved one died tragically, can God go back and prevent it? If you say yes, then wouldnt that require God to re-write all of reality, time and space and our memories from the moment of change forward? God would have to erase the butterfly effect right?

Or is God unable to change the past? And if He cannot change the past, then why is the future any different assuming the nature of time itself is constant?

Attachments: sdilfcmtbq.gif

42
Pregnancy and Addiction / -
« Last post by Cliftonpleme on June 01, 2025, 08:16:01 AM »
You could think of it as an opportunity to improve your skills as an instrument chaplain.

 Its a bigger part of the job than I ever thought it would be.

 Part of cradle to grave service.

Attachments: oqsuzmqkeh.gif

43
Astronomy / -
« Last post by Cliftonpleme on June 01, 2025, 01:48:08 AM »
It was another week of getting things done but not necessarily the things that I wanted to do in the order that I wanted to do.  The extra work load has been throwing me off.

Attachments: lxotdzomil.gif

44
Cannabis and Cannabinoids / Re: [USA] What is HHC and How Does it Compare to THC?
« Last post by qieji on May 30, 2025, 02:45:06 PM »
It seems a good news! I will have a try, I always use a lookah firebee 510 battery with my delta-8 THC cart, I will give HHC a try If the store has it.
45
The ‘3-word rule’ that makes ChatGPT give expert-level responses,
the concept is simple: Add a short, three-word directive to your prompt that tells ChatGPT how to respond. These three words can instantly shape the tone, voice and depth of the output. You’re not rewriting your whole question. You’re just giving the AI a lens through which to answer:

1. “Like a lawyer” — for structured, detailed and logical responses

2. “Be a teacher” — for simplified, clear and educational explanations

3. “Act like Hemingway” — for punchy, minimalist writing with impact
46
1. If a person starts shaking their leg as long as they sit down, they are intelligent.

2. If a person talks to themselves often, they have a sharp mind and deep thoughts.

3. If someone prefers staying quiet in a group, they are usually the smartest observer.

4. If a person gets bored easily, their brain craves higher intellectual stimulation.

5. If someone laughs at dark humor, they have a high IQ and advanced thinking skills.
47
🧬 Amino Acids with Psychoactive Synergy

This list includes amino acids known to influence neurotransmitter systems or support the action, metabolism, or recovery phases of major psychoactive drugs. For informational purposes only.


🌟 L-Tyrosine
💊 Synergy: Phenethylamines, Amphetamines, Dopamine Agonists 
🧠 Function: Precursor to dopamine, norepinephrine, and epinephrine 
⚠️ May enhance stimulant response or recovery from stimulant depletion


🌈 DL-Phenylalanine (DLPA)
💊 Synergy: Stimulants, Opiates 
🧠 Function: D-isomer inhibits enkephalinase (preserves endorphins), L-isomer is a dopamine precursor 
🛡️ May reduce pain and improve mood during stimulant or opiate withdrawal


🌀 L-Tryptophan
💊 Synergy: SSRIs, Empathogens, Tryptamines 
🧠 Function: Precursor to serotonin 
🌙 Supports sleep and mood regulation; do NOT mix with serotonergic drugs unsupervised


☯️ 5-HTP (5-Hydroxytryptophan)
💊 Synergy: MDMA, SSRIs, Psilocybin (Post-use Recovery) 
🧠 Function: Immediate precursor to serotonin 
🚨 Caution: Risk of serotonin syndrome with active serotonergic substances


⚡ L-Theanine
💊 Synergy: Stimulants, Psychedelics, Caffeine 
🧠 Function: Promotes calm focus via GABA and glutamate modulation 
🧘‍♂️ Smooths stimulant experience, reduces anxiety


💤 L-Glycine
💊 Synergy: NMDA Antagonists (Ketamine, DXM), GABAergics 
🧠 Function: Co-agonist at NMDA receptors; calming effects 
🌌 May enhance dream vividness, promote sleep


🧊 L-Glutamine
💊 Synergy: Dissociatives, Nootropics, Stimulants 
🧠 Function: Precursor to glutamate and GABA 
🔄 Supports CNS recovery after overstimulation


💪 L-Arginine
💊 Synergy: Psychedelics, Nootropics, MDMA 
🧠 Function: Boosts nitric oxide, enhances circulation 
❤️ May increase intensity of experience and body load


🔥 L-Citrulline
💊 Synergy: Phenethylamines, Sexual Enhancers 
🧠 Function: Converts to Arginine, increases NO 
🫀 Vasodilation may enhance physical rush or tactile pleasure


🛡️ L-Cysteine (NAC precursor)
💊 Synergy: Stimulants, Alcohol, MDMA 
🧠 Function: Antioxidant, glutathione precursor 
🧬 Protects against neurotoxicity and oxidative stress


⚙️ Acetyl-L-Carnitine (ALCAR)
💊 Synergy: Stimulants, Cognitive Enhancers 
🧠 Function: Enhances mitochondrial function and acetylcholine metabolism 
🔋 Boosts energy, reduces mental fatigue


🎯 Taurine
💊 Synergy: Stimulants, Alcohol, Benzodiazepines 
🧠 Function: GABAergic modulator 
🧘‍♀️ May blunt overstimulation and improve hydration


🧠 L-Histidine
💊 Synergy: MAO inhibitors, Dream Inducers 
🧠 Function: Histamine precursor, supports wakefulness and immune balance 
😵‍💫 High doses may cause vertigo or nausea in sensitive individuals


🌿 Beta-Alanine
💊 Synergy: Phenethylamines, Performance Drugs 
💥 Buffers lactic acid, may increase endurance or paresthesia 
⚠️ May intensify body tingles when mixed with stimulants


📜 Notes
  • ⚠️ Combining any supplement with psychoactive drugs carries risk—do your own research.
  • 🧪 These pairings are often based on anecdotal, nutritional, or experimental neuroscience data.
  • 🔍 Many of these amino acids also aid post-experience recovery or protect neurotransmitter systems.

Compiled by ChatGPT | Public Domain | For educational use only
48
Drugs / Ranked Street Substances by Combined Psychoactivity & Addictiveness
« Last post by Chip on May 29, 2025, 06:55:05 PM »
💊 Ranked Street Substances by Combined Psychoactivity & Addictiveness

RankSubstancePsychoactivityAddiction RiskCombinedNotes
1Carfentanil10Extreme14Extremely potent synthetic opioid (100x Fentanyl)
2Fentanyl9.5Extreme13.5Ultra-potent synthetic opioid
3Nitazenes (e.g., Isotonitazene)9.4Extreme13.4New ultra-potent opioid class, stronger than fentanyl
4Heroin9High12Semi-synthetic opioid; strong euphoria and sedation
5Methamphetamine9High12Potent central stimulant, long-acting
6Crack Cocaine8.5High11.5Smoked freebase form; intense, short-lived high
7Cocaine8High11Stimulant; short duration; strong DA/NE reuptake inhibition
8PCP8Moderate10NMDA antagonist; dissociative and deliriant effects
9Ketamine7.5Moderate9.5Dissociative anesthetic; NMDA antagonist
10MXE7.4Moderate9.4Longer-acting ketamine analog; dissociative
11MDMA (Ecstasy)7Moderate9Empathogen; serotonin and dopamine releaser
12Spice/K2 (Synthetic Cannabinoids)6High9Unpredictable synthetic cannabinoids
13LSD7.8Low8.8Classic serotonergic psychedelic
14DMT7.7Low8.7Ultra-short-acting intense psychedelic
155-MeO-DMT7.6Low8.6Non-visual, ego-dissolving psychedelic
16NBOMe compounds6.5Moderate8.5Highly potent 5-HT2A agonists
17Alcohol5.5High8.5GABAergic CNS depressant
18Psilocybin Mushrooms7.3Low8.3Serotonergic tryptamine psychedelic
19Toluene (Inhalant)5.2High8.2Solvent with disorienting CNS effects
20Marijuana (High-THC strains)6Moderate8Cannabinoid agonist; euphoria + relaxation
212C-B6.8Low7.8Psychedelic phenethylamine; visual + empathogenic
22Mescaline (Peyote/San Pedro)6.7Low7.7Natural psychedelic phenethylamine
23Benzodiazepines (e.g. Xanax, Valium)4.5High7.5GABA-A agonists; anxiolytic/sedative
24Ayahuasca6.3Low7.3Oral DMT + MAOI brew
25Salvia divinorum6.2Low7.2Kappa-opioid agonist; intense short hallucinations
26Barbiturates4.2High7.2GABA-A potentiators; older sedatives
27DXM (in high doses)5Moderate7OTC NMDA antagonist/dissociative
28Nitrous Oxide5.4Low6.4Dissociative gas; NMDA antagonist
29Codeine4Moderate6Weak opioid; often combined with paracetamol
30Kratom4Moderate6Mitragynine; mild opioid agonist/stimulant hybrid
31Tobacco (Nicotine)3High6Stimulant and neuromuscular modulator
32Zuclopenthixol3.8Low4.8Notazine antipsychotic; strong D2 blocker
33Flupenthixol3.7Low4.7Motivational lift + antipsychotic effects
34Clopenthixol3.6Low4.6Sedative Notazine; rarely used recreationally
35Haloperidol3.5Low4.5Potent typical antipsychotic; tranquilizer effect
36Olanzapine3.4Low4.4Atypical antipsychotic; heavy sedation in high doses
37Caffeine2Moderate4Adenosine receptor antagonist; mild stimulant
49
Drugs / Psychoactive Substances by Mechanism of Action of Interest
« Last post by Chip on May 29, 2025, 06:44:26 PM »
📚 Known Psychoactive Substances by Mechanism of Action of Interest

🔋 Dopamine Reuptake Inhibitors (DRIs)
- Methylphenidate
- Bupropion
- Ethylphenidate
- 4F-MPH
- HDMP-28
- Prolintane
- Desoxypipradrol (2-DPMP)
- Amineptine

🔥 Dopamine Releasers
- Amphetamine
- Methamphetamine
- PEA (Phenethylamine)
- Ethylhexedrone
- Mephedrone
- α-PVP
- 4-MEC
- Naphyrone

🧠 Serotonin Reuptake Inhibitors (SSRIs)
- Fluoxetine
- Sertraline
- Paroxetine
- Citalopram
- Escitalopram

💗 Serotonin Releasers and Agonists
- MDMA
- MDA
- MDEA
- MDAI
- 5-MAPB
- 4-FA
- Psilocybin
- LSD
- 5-MeO-DMT
- 2C-B
- 25I-NBOMe
- DMT
- 4-AcO-DMT

❄️ NMDA Receptor Antagonists
- Ketamine
- DXM
- MXE
- PCP
- 3-MeO-PCP
- Methoxphenidine
- Nitrous Oxide

💤 GABA-A Agonists (Anxiolytics/Sedatives)
- Diazepam
- Clonazepam
- Alprazolam
- Zolpidem
- Etizolam
- Phenobarbital
- Gabapentin

😴 GABA-B Agonists
- Phenibut
- Baclofen
- GHB

🧬 Acetylcholinesterase Inhibitors (AChE-Is)
- Galantamine
- Huperzine A
- Donepezil
- Tacrine
- Rivastigmine

🎨 5-HT2A Agonists (Psychedelics)
- LSD
- Psilocin
- 4-HO-MET
- 2C-E
- 2C-I
- DOC
- 25C-NBOMe
- Mescaline
- AL-LAD

🧪 MAO Inhibitors (MAOIs)
- Harmine
- Harmaline
- Selegiline
- Rasagiline
- Isocarboxazid
- Phenelzine

🧲 COMT Inhibitors
- Tolcapone
- Entacapone

🛑 Opioid Receptor Agonists
- Morphine
- Codeine
- Heroin
- Oxycodone
- Hydrocodone
- Fentanyl
- Methadone
- Buprenorphine

⚙️ Opioid Antagonists
- Naloxone
- Naltrexone
- Nalmefene

📈 Nootropic Racetams & Cognitive Enhancers
- Piracetam
- Aniracetam
- Oxiracetam
- Phenylpiracetam
- Noopept
- NSI-189
- Modafinil
- Centrophenoxine
- Uridine Monophosphate

💡 Neurosteroids and Hormonal Modulators
- DHEA
- Pregnenolone
- Arimidex
- Letrozole
- Clomiphene
- Tamoxifen
- Melatonin
- Testosterone

💉 Peptides and Neuropeptides
- Semax
- Selank
- DSIP
- Oxytocin
- Vasopressin
50
Drugs / All Known Psychoactive Drug Categories and Examples of Interest
« Last post by Chip on May 29, 2025, 06:34:53 PM »
📚 Psychoactive Drug Categories and Examples (Expanded)

🌿 Ethnobotanicals
- Ayahuasca — DMT + Harmine, Harmaline
- Ibogaine — Ibogaine
- Kava — Kavalactones
- Kratom — Mitragynine, 7-Hydroxymitragynine
- Salvia divinorum — Salvinorin A
- Peyote — Mescaline
- San Pedro Cactus — Mescaline
- Blue Lotus — Aporphine, Nuciferine
- Syrian Rue — Harmaline, Harmine (MAOIs)
- Yopo / Vilca — Bufotenin, 5-MeO-DMT
- Amanita muscaria — Muscimol, Ibotenic acid
- Calamus root — Beta-asarone
- Voacanga africana — Voacangine
- African Dream Root (Silene capensis) — Triterpenoid saponins
- Calea zacatechichi — Unknown bitter sesquiterpenes

🧠 Oneirogens (Dream Inducers)
- Calea zacatechichi — Dream herb
- Silene capensis — Xhosa dream root
- Galantamine — Acetylcholinesterase inhibitor
- Mugwort — Thujone, cineole
- Phenibut — β-Phenyl-GABA; GABA-B agonist with dream-enhancing properties

☠️ Deliriants (Anticholinergic Hallucinogens)
- Datura stramonium — Scopolamine, Atropine
- Brugmansia — Hyoscine
- Belladonna — Atropine, Scopolamine
- Diphenhydramine — H1 antagonist; anticholinergic in high doses
- Mandrake root — Scopolamine derivatives

💥 Designer Dopaminergics (Stimulant RCs)
- Prolintane — NDRI
- Ethylphenidate — Dopamine/NE reuptake inhibitor
- Isopropylphenidate — Longer acting analog
- Desoxypipradrol (2-DPMP) — Ultra-long acting stimulant

🧬 Peptides / Neuropeptides
- Semax — ACTH(4-10) analog, nootropic, anxiolytic
- Selank — Tuftsin analog, anxiolytic, immune-modulating
- DSIP — Delta sleep-inducing peptide
- Oxytocin — Social bonding, trust, cognition
- Vasopressin — Memory, aggression modulation

🧫 Immunopsychoactives (Inflammation-Modulating Psychoactives)
- LPS (Lipopolysaccharide) — Induces sickness behavior in animal models
- Infliximab — TNF-alpha blocker studied for depression
- IL-6 modulators — Linked to mood regulation in current research

🌬️ Inhalants and Volatile Agents
- Nitrous Oxide — NMDA antagonist
- Amyl Nitrite — Vasodilator, mild euphoria
- Butyl Nitrite — “Poppers”, similar to amyl
- Toluene — Solvent abuse (dangerous)
- Ether — Legacy anesthetic
- Chloroform — CNS depressant, toxic

🎨 Psychedelic Amphetamines (DOx / NBOMe Class)
- DOC — 4-chloro-2,5-dimethoxyamphetamine
- DOB — 4-bromo-2,5-dimethoxyamphetamine
- DOI — 4-iodo-2,5-dimethoxyamphetamine
- 25I-NBOMe — Extremely potent 5-HT2A agonist
- 25C-NBOMe — Chlorinated analog

🧪 Hormonal Modulators (Neuroendocrine-Linked Psychoactivity)
- Arimidex (Anastrozole) — Aromatase inhibitor
- Letrozole — Estrogen synthesis blocker
- Clomiphene — Estrogen receptor modulator
- Tamoxifen — SERM; sometimes nootropic-like effects
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