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I had a 79 Camaro that I put a new engine in. It wasnt exactly "stock" and I could easily bury the speedometer that went to 130. So-Id say around 130 was the fastest I have ever driven.
How fast would you drive if there was no speed limit?
32
A nice theory that someone hopes to test soon is that anti-matter produces anti-gravity - that matter and anti-matter repel each other.
Then, if there were areas of deep space filled with diffuse anti-matter, this might eplain ekz key is broken on my keyboard dark energy - and why the epansion of the universe is accelerating.
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« Last post by Chip on June 02, 2025, 02:04:11 PM »
🔥 Piperine Synergy & PotentiationPiperine is the primary active alkaloid in black pepper ( Piper nigrum) and functions as a powerful bioavailability enhancer, modulating both Phase I (CYP450) and Phase II (glucuronidation) metabolic pathways.
🧬 Key Mechanisms- Inhibits CYP3A4, CYP2D6, CYP2E1 – Slows drug metabolism
- Blocks UDP-glucuronosyltransferase (UGT) – Prevents rapid excretion
- Enhances absorption via intestinal epithelial permeability
- Increases thermogenesis and blood flow in the gut
⚡ Optimal Dosage| Formulation | Typical Dose | | Piperine extract (BioPerine®) | 5–20 mg | | Black pepper (powdered spice) | 250–500 mg |
🧠 Therapeutic effect begins at 5 mg of standardized piperine extract. Doses over 20 mg may cause GI irritation.
🔥 Substances Potentiated by Piperine🧠 Nootropics & Neuromodulators- Curcumin – Up to 2000% ↑ absorption
- Resveratrol – Higher blood plasma retention
- 5-HTP – Slower breakdown, stronger mood support
- L-DOPA / Mucuna – Prolonged dopaminergic effect
- Phenethylamine (PEA) – Longer duration, stronger stimulation
- Hordenine – Extended TAAR1 activity
- Caffeine – Slower metabolism, extended half-life
- Modafinil – Mild potentiation of wakefulness
💊 Supplements & Adaptogens- Berberine – Enhanced glucose modulation
- Quercetin – Amplified antioxidant effects
- Bacopa Monnieri – Improved cognitive support
- CoQ10 – Greater mitochondrial delivery
- Melatonin – Longer sleep duration
- Fat-soluble Vitamins (A, D, E, K) – Improved absorption
🌿 Cannabinoids- CBD / THC – Increased potency and duration
⚠️ May raise anxiety levels at high doses
⏱️ Timeline of Effects| Time After Ingestion | Effect | | 0–10 min | Initial absorption in GI tract begins | | 10–30 min | CYP/UGT enzyme inhibition takes effect | | 30–45 min | Peak potentiation of target substances | | 1–3 hours | Sustained enhancement of absorption/metabolism | | 3–6 hours | Gradual return to baseline enzyme activity |
🚨 ⚠️ Pharmaceutical Interactions ⚠️ 🚨Due to CYP and UGT inhibition, Piperine may dangerously increase levels of: - Benzodiazepines (Diazepam, Clonazepam)
- SSRIs / SNRIs (Sertraline, Venlafaxine)
- Opioids (Morphine, Oxycodone)
- Beta-blockers (Metoprolol, Atenolol)
- MAO inhibitors – Hypertensive risk
- Anticoagulants (Warfarin) – Bleeding risk
❗ Avoid combining piperine with narrow therapeutic index medications unless supervised by a medical professional.
⚙️ Integration Tips- Dose 10–15 minutes before target compound
- Use 5–10 mg Piperine extract, or 250–300 mg black pepper powder
- Cycle use to avoid enzyme over-inhibition or tolerance
🧠 Notes for Formulators- Piperine is lipophilic – combine with fats or oils for best effect
- Highly synergistic with methyl donors, dopaminergics, and anti-inflammatory agents
- Acts as a natural AMPK modulator, supporting metabolic and neuroprotective stacks
Created for Neurostack Optimization — by Chipper 🔗 GitHub Repo: NeuroOverride Stack
34
My fellow dinosaurs still on buckets:
Im frustrated by Bucket Blowout Syndrome BBS. Its not uncommon for the spile to tear through the sidewall of my plastic bucket, spilling a good amount of sap. Bucket quality and age probably factor in. Ive tried different spiles. Several years ago I used the cast aluminum "shark fin" spiles that easily tore through the bucket above the hole. I tried inserting a washer between the fin and the bucket wall but that was cumbersome. Im currently using Sap Meister spiles that have a built-in washer but they tear through also.
Any ideas on how to prevent? Ive tried running tubing to a bucket on the ground but that takes time to setup with different lengths of tubing each year.
Thanks for ideas.
Marc
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Extensor action
A discussion has arisen about extensor action in oz forum,hopefully we can find out more here on the home of TGM.
ADVANTAGES.....what are the advantages? .Can it be overdone?....and what are the signs of overkill in extensor action
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Quite a few, actually all 45s. I do not recheck often, so not sure how many are still truly UTR at least dozens, possibly hundreds. Still lots out there IMO, but as mentioned above, how many are any good?
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"You must take your opponent into a deep, dark forest, where 22=5, and the path leading out is only wide enough for one"
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« Last post by smfadmin on June 01, 2025, 03:48:44 PM »
HOW TO RESPECT YOURSELF
1. Stop begging others.
2. Stop saying more than necessary.
3. Stop looking for who is not looking for you.
4. Invest in yourself and make yourself happy.
5. Stop entertaining gossip about other people.
6. When people disrespect you, confront them immediately.
7. Don't eat other people's food more than they eat yours.
8. Always look your best; dress the way you should be addressed.
9. Reduce how often you visit some people, especially if they don't reciprocate
10. Think before you talk; 80% of how people value you is what comes out of your mouth.
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« Last post by smfadmin on June 01, 2025, 03:14:18 PM »
Your post is irrelevant so why post it here ?
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i would check out the quality of ikon shocks before you buy your next set terry . they used to be great when they were made in australia but the last set i bought were not so good . when i checked the box it said assembled in australia so i guess they are now made in china .
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