dopetalk
Core Topics => Drugs => GABAergics and VGCC Blockers => Topic started by: smfadmin on November 30, 2025, 04:23:03 PM
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⚠️ Multiple BDO Education, Hypothetical Session Summary & Post-Use Harm Reduction⚠️
This sticky is for documentation and harm-reduction purposes only.
ALSO see: What is 1,4-BDO ? (https://forum.drugs-and-users.org/index.php?action=post;msg=47305;topic=5853.0) and BDO (1,4-Butanediol) Dosing Overview (https://forum.drugs-and-users.org/index.php?topic=6252.0)
It contains no dosing guidance for BDO/GHB and does NOT encourage use (see avove).
My Metabolic Data:
BDO (1,4-Butanediol)
│ [Alcohol Dehydrogenase, ADH]
▼
γ-Hydroxybutyraldehyde (GHBA)
│ [Aldehyde Dehydrogenase, ALDH]
▼
GHB
→ Neurochemical targets: 2-3 hour GABA-B agonism, combined delayed dopamine rebound, temporary serotonin satiety
Session Summary
• Total reported intake: approximately ~23 ml BDO, more-or-less spread out evenly (with 1 ml attenuation across the entire TWO DAY session) BUT WITH A VERY HIGH GABA TOLERANCE ACQUIRED FROM BDO USE AND ALCOHOLISM !!!
• Status at last check-in: fully alert, airway clear, side-lying position (THE RECOVERY POSITION) maintained
• Key risk factors:
– ⚠️ High cumulative intake (dangerous for most users)
– 🧠 Consciousness does not imply safety; tolerance is masking risk
– 🫁 BDO/GHB sedation can occur suddenly and silently
– ❤️ Cardiac rhythm abnormalities (e.g., A-fib) increase risk
– ⏳ Delayed effects possible even after feeling “fine”
Immediate Safety Notes
• ➡️ Stay on your side, head slightly elevated (recovery position)
• ⏰ Remain awake and responsive
• 🔄 Regularly monitor alertness and breathing
• 🚫 Do not take additional substances
• 📞 Seek emergency help if: consciousness drops, breathing slows, or heart rhythm changes
Post-BDO Harm-Reduction & Supplement Support
These supplements help recovery and liver support after heavy BDO use:
Essential Supplements
• 💧 Electrolytes – Sodium, potassium, magnesium to correct dehydration and maintain heart rhythm
• 💊 Thiamine (B1) – Supports cognitive function and metabolism; 100–300 mg standard or 50–100 mg benfotiamine
• 🧪 NAC (N-acetylcysteine) – Regenerates glutathione and reduces liver strain; 600–1200 mg
• ⚡ Alpha-lipoic acid (ALA) – Supports glutathione recycling; 100–200 mg
Optional Support
• 🌿 Milk Thistle (Silymarin) – Liver support
• 🐚 Taurine – Calcium regulation, liver and osmolality support; 1–2 g
• 🟢 Magnesium Glycinate – Calms jitters; 200–400 mg
What to Avoid Right Now
• 🚫 Phenibut, benzos, or strong GABAergic supplements
• 🚫 High-dose melatonin
• 🚫 Mega-doses of antioxidants in short intervals
• 🚫 Any further depressants (alcohol, BDO, etc.)
Extra Harm-Reduction Tips
• 🍽 Eat a balanced meal with protein and carbs
• 💧 Hydrate well over 6 hours
• ⏳ Wait at least 2–3 hours between supplements
• 🛏️ Rest in a side-lying or slightly elevated position, remain awake if sedated
Important Reminder
⚠️ These measures support recovery and liver function but **do not eliminate risk**.
Heavy BDO use remains dangerous, even if short and long term tolerances temporarily keeps you conscious.
Always monitor alertness, breathing, and heart rhythm closely.