dopetalk
Core Topics => Drugs => Phenethylamines => Topic started by: smfadmin on November 07, 2025, 01:13:48 PM
-
Methamphetamine Bioavailability by ROA
IV (Injection): ~100%
Direct systemic entry. Highest vascular + infection risk.
Smoking (Freebase Vapor): ~90–98%
Fastest onset + hardest reinforcement loop (most addictive).
Insufflated (Snorted): ~70–90%
Varies with pH + technique. Chronic sinus damage common.
Oral (Swallowed): ~62–79%
Smoothest curve, longest duration, lowest compulsion spike.
Rectal (Plugging): ~70–80%
Avoids most first-pass. Stronger and faster than oral.
Sublingual / Buccal: ~50–60%
Most swallowed; inconsistent absorption.
IM (Intramuscular): ~80–90%
Slower than IV, weaker rush. Infection risk still present.
Onset & Reinforcement Profiles
Smoking / IV: Seconds | Highest DA spike → strongest addiction loop
Snorted / Rectal: 3–10 min | Moderate reinforcement
Oral: 20–45 min | Lowest reinforcement, more stable use pattern
Harm Reduction Guidance
• If aiming to control tolerance → choose Oral or Rectal
• Smoking and IV accelerate tolerance fastest
• Keep minimum 72 hours spacing between runs
• Avoid stacking stimulants with sleep deprivation
Supplements That Provide Actual Benefit
• Magnesium – NMDA regulation
• NAC – reduces oxidative stress + glutamate dysregulation
• DHA / Omega-3 – neuronal membrane stabilization
• Vitamin C – antioxidant + post-run recovery
• Adequate Sleep – mandatory for synaptic reset
Summary:
Snorting wastes drug + damages tissue.
Smoking/IV = strongest dopamine spike → steep tolerance ramp.
Oral/Rectal = smoother kinetics → easiest to keep usage functional.