dopetalk
Core Topics => Drugs => Amino Acids and Supplements => Topic started by: smfadmin on August 29, 2025, 09:26:44 AM
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🧠 Dopamine & MA + Piperine / Hordenine Stack — Condensed Notes
1. Piperine + Dopamine Receptors
💊 Piperine **does NOT directly increase dopamine receptor sensitivity**
⚡ Main effect: **CYP3A4/CYP2D6 inhibition**, slows MA metabolism → higher, longer dopamine
🧪 Mild **MAO inhibition** possible
⚠️ High doses (200 mg+) → gut irritation, unpredictable effects
2. Effects of MA + Piperine
⏳ Slower onset, **sharper peak once absorbed**
📈 **Extended plateau** → longer functional stimulation
❌ Piperine increases exposure, **does not restore receptor sensitivity**
3. Hordenine + MA + Piperine
🌿 Hordenine: **NRI + mild TAAR1 activity**, additive with MA
⏱ Piperine slows Hordenine clearance → stronger effect
💥 Combined: higher norepinephrine + dopamine, longer duration, elevated HR/BP
⚠️ Not a resensitizer — stresses desensitized receptors
4. Timeline of Effects (150 mg MA + 200 mg Piperine + 450 mg Hordenine)
| Time | Effect |
|------------|--------|
| 0–0.5 hr | Mild alertness, delayed onset |
| 0.5–2 hr | Rising phase; jitters, mild jaw tension |
| 2–6 hr | Peak/plateau; functional stimulation, motivation, cardiovascular load |
| 6–12 hr | Declining; wired tail, restlessness, appetite suppression, sleep disruption |
| 12–24 hr | Comedown; fatigue, low mood, mental fog, gut irritation |
5. Dopamine Receptor Resensitization
🔹 High MA tolerance → D1/D2 downregulation
🔹 Recovery = **rest receptors, not more dopamine**
Recovery Protocol (60 × 1000 mg CDP-Choline)
💊 Core Stack:
- CDP-Choline: 250–500 mg AM with food/fat
- Omega-3 (DHA/EPA): 1000–2000 mg/day
- Magnesium glycinate/threonate: 200–400 mg PM
🧩 Optional Builders:
- Uridine Monophosphate: 150–250 mg AM
- NAC: 600–1200 mg/day
- B-vitamins: B6, B9, B12
🏃 Lifestyle:
- Exercise 3–5×/week → boosts D2 receptor density
- Solid sleep → receptor density rebounds
- Novelty/learning → natural dopamine stimulation
⏱ Timeline:
- 1–2 weeks → subtle clarity/focus
- 1–2 months → reward sensitivity improves
- 3+ months → motivation rebound
- 3–6 months → major receptor recovery (if MA minimal)
⚠️ MA Use During Recovery:
- Low-dose or spaced out only
- Micro-dosing occasionally okay, frequent use slows recovery
6. CDP-Choline Notes
- Supports **receptor density, synapse repair, membrane health**
- Works best with **DHA + uridine**
- Dose: 250–500 mg/day, split 1000 mg capsules
- Benefits over **weeks–months**
- Supply: 60 × 1000 mg → ~4 months at 500 mg/day
7. Safety & Warnings
- MA + Piperine + Hordenine → increased cardiovascular load; monitor HR/BP
- Piperine prolongs clearance → longer effects
- Gut irritation, restlessness, insomnia possible
- Stack **does NOT resensitize receptors**; repeated use worsens tolerance
8. TL;DR
- ⚡ Piperine = metabolic amplifier, not receptor fixer
- 🧠 CDP-Choline + DHA + uridine + magnesium + lifestyle = true receptor rebuilding
- 🚀 MA/Hordenine/Piperine = functional boost, long tail, receptor stress
- 🔑 Recovery = **time off stimulants + nutrition + exercise + sleep**