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Core Topics => Drugs => Amino Acids and Supplements => Topic started by: Chip on July 06, 2025, 04:03:39 PM
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🍺 Alcohol Harm Minimisation Stack
User profile: ~20 standard drinks/week
Goal: Protect liver, brain, mood, and mitochondria from ethanol exposure.
🧠 Core Daily Supplements
- NAC (N-acetylcysteine): 600–1200 mg 1–2x/day – boosts glutathione; protects liver 🛡️
- B-Complex (active forms): High-potency – replaces depleted B1, B6, B12, folate 💊
- Magnesium (glycinate or threonate): 200–400 mg – CNS calming, helps sleep and GABA 💤
- ALA (Alpha Lipoic Acid): 300–600 mg – antioxidant and mitochondrial support 🔋
- Vitamin C: 1000 mg – antioxidant; helps detox 🍊
- Milk Thistle (Silymarin): 300–600 mg – proven liver support 🌿
- Taurine: 500–1000 mg – supports bile, liver, and calming ⚡
- Zinc (Picolinate or Bisglycinate): 25–50 mg – immune and liver cofactor 🛠️
⚠️ Optional / Cycled (2–3x per week or on drinking days)
- TUDCA: 250–500 mg – bile flow + membrane protection
- Curcumin (Meriva/Longvida): 500–1000 mg – anti-inflammatory and neuroprotective 🧠
- CoQ10 or Ubiquinol: 100–200 mg – mitochondria + heart health ❤️
- DHM (Dihydromyricetin): 300–600 mg – anti-hangover; helps liver enzymes 🍃
💧 Behavior Tips
- Use electrolytes before and after drinking (coconut water + salt).
- Avoid paracetamol (acetaminophen) when drinking – it's liver toxic.
- Eat protein + fat before alcohol to slow absorption.
- Activated charcoal (1–2g) only AFTER final drink, if bloated.
- Liver function tests (LFTs) are recommended every few months.
✅ Optional Add-ons
- Broccoli sprouts / Sulforaphane – activates detox genes (NRF2)
- Resveratrol – NAD+ preservation, antioxidant
- Choline or CDP-Choline – combats brain fog
🧪 This stack won’t make alcohol safe, but it’s your biochemical armour if you’re drinking regularly.