dopetalk
Core Topics => Drugs => Amino Acids and Supplements => Topic started by: Chip on June 27, 2025, 12:06:50 PM
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🧬 Metabolic Effects: PEA + Methamphetamine + ALCAR + SAMe
🧠 1. Phenylethylamine (PEA)
- Rapidly broken down by MAO-B into phenylacetic acid.
- Brief spikes in dopamine, norepinephrine, serotonin.
- Short-lived unless MAO-B is inhibited.
🔥 2. Methamphetamine (MA)
- Increases dopamine, norepinephrine, serotonin via VMAT2 inhibition.
- Inhibits MAO, making PEA more effective.
- Induces oxidative stress in neurons.
⚡ 3. ALCAR (Acetyl-L-Carnitine)
- Enhances mitochondrial energy metabolism.
- Reduces oxidative damage.
- Improves dopamine receptor sensitivity.
🔁 4. SAMe (S-Adenosylmethionine)
- Primary methyl donor for neurotransmitter production.
- Supports COMT → dopamine breakdown.
- Boosts glutathione production and detox processes.
🧪 Combined Effects
- PEA + MA: MA inhibits MAO → PEA lasts longer → intense stimulation ⚡
- MA + ALCAR: MA stresses mitochondria → ALCAR counters it 🔋
- ALCAR + SAMe: Energy + methylation synergy 🔁
- MA + SAMe: Dopamine synthesis + breakdown maintained 🧬
⚠️ Key Risks
- Hypertensive Crisis: MA + PEA → extreme BP & HR 💣
- Neurotoxicity: Dopamine overflow → ROS damage 💥
- Serotonin Syndrome: Rare but possible with SSRI/5-HTP ⚠️
- Tolerance: Downregulation & depletion 📉
✅ Benefits (With Caution)
- 🚀 Increased focus, euphoria, motivation
- 🔋 Better mitochondrial health
- 🧬 Enhanced neurotransmitter turnover
🧠 Final Summary
Combining PEA + MA + ALCAR + SAMe creates a potent metabolic synergy of:
- High stimulant potential
- Mitochondrial and cognitive support
- Improved methylation & detox
…but also demands caution due to:
- Cardiovascular risk
- Tolerance buildup
- Oxidative stress
NB: Using supplements can preserve your health so do your own research (or ask me) so take plenty of care and do not be blasé !