| Rank | Substance | Psychoactivity | Addiction Risk | Combined | Notes |
| 1 | Carfentanil | 10 | Extreme | 14 | Extremely potent synthetic opioid (100x Fentanyl) |
| 2 | Fentanyl | 9.5 | Extreme | 13.5 | Ultra-potent synthetic opioid |
| 3 | Nitazenes (e.g., Isotonitazene) | 9.4 | Extreme | 13.4 | New ultra-potent opioid class, stronger than fentanyl |
| 4 | Heroin | 9 | High | 12 | Semi-synthetic opioid; strong euphoria and sedation |
| 5 | Methamphetamine | 9 | High | 12 | Potent central stimulant, long-acting |
| 6 | Crack Cocaine | 8.5 | High | 11.5 | Smoked freebase form; intense, short-lived high |
| 7 | Cocaine | 8 | High | 11 | Stimulant; short duration; strong DA/NE reuptake inhibition |
| 8 | PCP | 8 | Moderate | 10 | NMDA antagonist; dissociative and deliriant effects |
| 9 | Ketamine | 7.5 | Moderate | 9.5 | Dissociative anesthetic; NMDA antagonist |
| 10 | MXE | 7.4 | Moderate | 9.4 | Longer-acting ketamine analog; dissociative |
| 11 | MDMA (Ecstasy) | 7 | Moderate | 9 | Empathogen; serotonin and dopamine releaser |
| 12 | Spice/K2 (Synthetic Cannabinoids) | 6 | High | 9 | Unpredictable synthetic cannabinoids |
| 13 | LSD | 7.8 | Low | 8.8 | Classic serotonergic psychedelic |
| 14 | DMT | 7.7 | Low | 8.7 | Ultra-short-acting intense psychedelic |
| 15 | 5-MeO-DMT | 7.6 | Low | 8.6 | Non-visual, ego-dissolving psychedelic |
| 16 | NBOMe compounds | 6.5 | Moderate | 8.5 | Highly potent 5-HT2A agonists |
| 17 | Alcohol | 5.5 | High | 8.5 | GABAergic CNS depressant |
| 18 | Psilocybin Mushrooms | 7.3 | Low | 8.3 | Serotonergic tryptamine psychedelic |
| 19 | Toluene (Inhalant) | 5.2 | High | 8.2 | Solvent with disorienting CNS effects |
| 20 | Marijuana (High-THC strains) | 6 | Moderate | 8 | Cannabinoid agonist; euphoria + relaxation |
| 21 | 2C-B | 6.8 | Low | 7.8 | Psychedelic phenethylamine; visual + empathogenic |
| 22 | Mescaline (Peyote/San Pedro) | 6.7 | Low | 7.7 | Natural psychedelic phenethylamine |
| 23 | Benzodiazepines (e.g. Xanax, Valium) | 4.5 | High | 7.5 | GABA-A agonists; anxiolytic/sedative |
| 24 | Ayahuasca | 6.3 | Low | 7.3 | Oral DMT + MAOI brew |
| 25 | Salvia divinorum | 6.2 | Low | 7.2 | Kappa-opioid agonist; intense short hallucinations |
| 26 | Barbiturates | 4.2 | High | 7.2 | GABA-A potentiators; older sedatives |
| 27 | DXM (in high doses) | 5 | Moderate | 7 | OTC NMDA antagonist/dissociative |
| 28 | Nitrous Oxide | 5.4 | Low | 6.4 | Dissociative gas; NMDA antagonist |
| 29 | Codeine | 4 | Moderate | 6 | Weak opioid; often combined with paracetamol |
| 30 | Kratom | 4 | Moderate | 6 | Mitragynine; mild opioid agonist/stimulant hybrid |
| 31 | Tobacco (Nicotine) | 3 | High | 6 | Stimulant and neuromuscular modulator |
| 32 | Zuclopenthixol | 3.8 | Low | 4.8 | Notazine antipsychotic; strong D2 blocker |
| 33 | Flupenthixol | 3.7 | Low | 4.7 | Motivational lift + antipsychotic effects |
| 34 | Clopenthixol | 3.6 | Low | 4.6 | Sedative Notazine; rarely used recreationally |
| 35 | Haloperidol | 3.5 | Low | 4.5 | Potent typical antipsychotic; tranquilizer effect |
| 36 | Olanzapine | 3.4 | Low | 4.4 | Atypical antipsychotic; heavy sedation in high doses |
| 37 | Caffeine | 2 | Moderate | 4 | Adenosine receptor antagonist; mild stimulant |