dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse

This website has run out of funding so feel free to contribute if you can afford it (see footer)

Author Topic: Bioavailability of Methamphetamine  (Read 10203 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6648
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Yesterday at 05:53:23 PM
  • Deeply Confused Learner
  • Profession: IT Engineer
Bioavailability of Methamphetamine
« on: December 25, 2015, 01:18:04 AM »
Bioavailability of methamphetamine is as follows:

62.7% oral; 79% nasal; 90.3% smoked; 99% rectally; 100 % IV.

sourced from drugs-forum.com
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
Our Discord Server invitation link is https://discord.gg/jB2qmRrxyD

Offline Guts

  • Sr. Member
  • ****
  • Join Date: Oct 2015
  • Location:
  • Posts: 1009
  • Reputation Power: 36
  • Guts is working their way up.Guts is working their way up.Guts is working their way up.
  • Last Login:April 25, 2019, 10:04:31 PM
  • Our Community Board
Re: Bioavailability of Methamphetamine
« Reply #1 on: December 25, 2015, 02:29:43 AM »
Taken orally, does meth work kinda like h? Does it lose the methyl group and become regular amphetamine?
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions

Offline Narkotikon

  • Honest
  • Sr. Member
  • ****
  • SA_Chat+
  • **
  • Join Date: Jun 2015
  • Location: USA
  • Posts: 1141
  • Reputation Power: 50
  • Narkotikon has got loads of potential.Narkotikon has got loads of potential.Narkotikon has got loads of potential.Narkotikon has got loads of potential.Narkotikon has got loads of potential.
  • Gender: Male
  • Last Login:March 28, 2016, 11:31:11 PM
  • Keeping Them Honest
Re: Bioavailability of Methamphetamine
« Reply #2 on: December 26, 2015, 12:39:56 AM »
I'm gonna say no, simply because there is pharmaceutical meth. It's called Desoxyn. It's used to treat ADHD, narcolepsy, and also for obesity I think. If it was converted back into amphetamine they'd simply use Dexedrine / dextroamphetamine.

Take that with a serious grain of salt though. I've never taken meth orally. I've only smoked glass a handful of times. I'm sure our resident meth expert will chime in with a definitive answer.
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
Transparency is necessary to ensure decent staff members get elected. Members need to know when staff are misbehaving, so members can be informed voters.

Offline Guts

  • Sr. Member
  • ****
  • Join Date: Oct 2015
  • Location:
  • Posts: 1009
  • Reputation Power: 36
  • Guts is working their way up.Guts is working their way up.Guts is working their way up.
  • Last Login:April 25, 2019, 10:04:31 PM
  • Our Community Board
Re: Bioavailability of Methamphetamine
« Reply #3 on: December 26, 2015, 02:21:01 AM »
They made pharmaceutical oral heroin at one point too... the higher lipid solubility allows it a higher BA even though its converted back to morphine. I'll wait on out expert though :)
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions

Offline Reezy

  • Full Member
  • ***
  • SA_Chat+
  • **
  • Join Date: Aug 2015
  • Location:
  • Posts: 237
  • Reputation Power: 13
  • Reezy is new on the scene.
  • Gender: Male
  • Last Login:November 20, 2018, 02:50:54 PM
  • Welcome to our community forum ...
Re: Bioavailability of Methamphetamine
« Reply #4 on: December 26, 2015, 11:08:32 AM »
Quote
Following oral administration, methamphetamine is well-absorbed into the bloodstream, with peak plasma methamphetamine concentrations achieved in approximately 3.13–6.3 hours post ingestion.[102] Methamphetamine is also well absorbed following inhalation and following intranasal administration.[9] Due to the high lipophilicity of methamphetamine, it can readily move through the blood–brain barrier faster than other stimulants, where it is more resistant to degradation by monoamine oxidase.[9][102] The amphetamine metabolite peaks at 10–24 hours.[9] It is excreted by the kidneys, with the rate of excretion into the urine heavily influenced by urinary pH.[20][102] When taken orally, 30–54% of the dose is excreted in urine as methamphetamine and 10–23% as amphetamine.[102] Following IV doses, about 45% is excreted as methamphetamine and 7% as amphetamine.[102] The half-life of methamphetamine is variable with a mean value of between 5 and 12 hours.[9][102]

CYP2D6, dopamine β-hydroxylase, flavin-containing monooxygenase, butyrate-CoA ligase, and glycine N-acyltransferase are the enzymes known to metabolize methamphetamine or its metabolites in humans.[4][5][6][7][103] The primary metabolites are amphetamine and 4-hydroxymethamphetamine; other minor metabolites include: 4-hydroxyamphetamine, 4-hydroxynorephedrine, 4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, and phenylacetone, the metabolites of amphetamine.[3][102][104][105] Among these metabolites, the active sympathomimetics are amphetamine, 4‑hydroxyamphetamine,[106] 4‑hydroxynorephedrine,[107] 4-hydroxymethamphetamine,[102] and norephedrine.[108]

The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N-oxidation, N-dealkylation, and deamination.[3][102][104] The known metabolic pathways include:[3][102][105]

So no, not like H to M. but amphetamine is a metabolite though it seems.
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions

Tags:
 

Related Topics

  Subject / Started by Replies Last post
0 Replies
7778 Views
Last post June 07, 2015, 07:50:37 AM
by Chip
6 Replies
11564 Views
Last post December 26, 2019, 05:56:10 AM
by Chip
2 Replies
9010 Views
Last post July 23, 2015, 09:16:12 PM
by Chip
4 Replies
9971 Views
Last post January 16, 2018, 07:53:52 AM
by Chip
0 Replies
8484 Views
Last post August 11, 2015, 12:03:32 AM
by Chip
3 Replies
7002 Views
Last post September 24, 2015, 11:34:51 AM
by Jega
6 Replies
9531 Views
Last post July 03, 2016, 10:10:42 PM
by Chip
0 Replies
6057 Views
Last post May 22, 2018, 03:40:26 AM
by Chip
0 Replies
4892 Views
Last post May 22, 2018, 03:50:20 AM
by Chip
0 Replies
4396 Views
Last post September 10, 2023, 01:15:25 PM
by Chip


dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse





TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE


Founded December 2014
SimplePortal 2.3.6 © 2008-2014, SimplePortal