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Core Topics => Tolerance => Topic started by: Chip on July 12, 2019, 07:49:50 AM

Title: Why roadside drug (and even alcohol) tests are not always fair
Post by: Chip on July 12, 2019, 07:49:50 AM

I have been researching tolerance and looking for any genetic indicators for possibly using genes to "tell" how much a person is tolerant to a particular drug.

As we all know, some of us function normally and in a totally sober fashion when we end up maintaining on our drugs(s) of choice.

For example, a person who drinks over 10 standard drinks a day will show no signs of intoxication if their blood alcohol limit is raised above the legal limit. So too for drug use and therein in lies the inadequacies and unfairness in such testing

An abstract can be found below on the Involvement of gene expression in drug tolerance and dependence can be found at https://www.ncbi.nlm.nih.gov/pubmed/7975924

The development of drug tolerance and dependence are thought to be associated with gene expression. Our studies showed that the binding activity of nuclear factors to several DNA sequences is altered by long-term treatment with methamphetamine, cocaine and morphine:

1) the binding activity of AP-1 increased markedly in the mouse brain after administration of methamphetamine and cocaine,

2) CRE-binding activity was decreased by chronic morphine treatment in the amygdala complex, cerebral cortex and hypothalamus of the mouse brain.

3) The binding activity of single-stranded CRE binding proteins^Wiki was decreased by chronic morphine treatment in the mouse cerebellum.

This data suggest that the changes of DNA binding proteins can be involved in the development of drug tolerance
 and dependence.