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Core Topics => Drugs => Exogenous/Endogenous Human Morphine Antagonistic Therapeutics => Topic started by: Chip on May 04, 2019, 02:56:04 PM

Title: Anhedonia to music and mu-opioids: Evidence from Naltrexone administration
Post by: Chip on May 04, 2019, 02:56:04 PM
source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296903/

Abstract

Music’s universality and its ability to deeply affect emotions suggest an evolutionary origin. Previous investigators have found that naltrexone (NTX), a μ-opioid antagonist, may induce reversible anhedonia, attenuating both positive and negative emotions. The neurochemical basis of musical experience is not well-understood, and the NTX-induced anhedonia hypothesis has not been tested with music. Accordingly, we administered NTX or placebo on two different days in a double-blind crossover study, and assessed participants’ responses to music using both psychophysiological (objective) and behavioral (subjective) measures. We found that both positive and negative emotions were attenuated. We conclude that endogenous opioids are critical to experiencing both positive and negative emotions in music, and that music uses the same reward pathways as food, drug and sexual pleasure. Our findings add to the growing body of evidence for the evolutionary biological substrates of music.
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