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Core Topics => Drugs => Cannabis and Cannabinoids => Topic started by: Chip on May 27, 2019, 10:58:02 PM

Title: Oleylethanolamide, Satiety, Love and the Endocannabinoid system
Post by: Chip on May 27, 2019, 10:58:02 PM

... So i was thinking about better ways of losing weight and after reviewing a lots of studies on brain fats, i came across Oleylethanolamide^Wiki but as of yet, have not purchased and not have i tried it.

Here is some info that i found:

Endocannabinoid system^Wiki

(look it up, it's bountiful)

The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons.

at https://www.ncbi.nlm.nih.gov/pubmed/23959001

Quote

Abstract

The anandamide monounsaturated analogue oleoylethanolamide (OEA) acts as satiety signal released from enterocytes upon the ingestion of dietary fats to prolong the interval to the next meal. This effect, which requires intact vagal fibers and intestinal PPAR-alpha receptors, is coupled to the increase of c-fos and oxytocin mRNA expression in neurons of the paraventricular nucleus (PVN) and is prevented by the intracerebroventricular administration of a selective oxytocin antagonist, thus suggesting a necessary role of oxytocinergic neurotransmission in the pro-satiety effect of OEA. By brain microdialysis and immunohistochemistry, in this study we demonstrate that OEA treatment can stimulate oxytocin neurosecretion from the PVN and enhance oxytocin expression at both axonal and somatodendritic levels of hypothalamic neurons. Such effects, which are maximum 2h after OEA administration, support the hypothesis that the satiety-inducing action of OEA is mediated by the activation of oxytocin hypothalamic neurons.