Prozac Shows Promise in Fighting Infections & Sepsis

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https://neurosciencenews.com/prozac-sepsis-neuropharmacology-28418/

Prozac Shows Promise in Fighting Infections & Sepsis

February 14, 2025

Summary: New research suggests that fluoxetine, commonly used as an antidepressant, may also help protect against infections and sepsis. Scientists found that the drug has antimicrobial properties and helps regulate the immune response, reducing the risk of tissue and organ damage.

In mice, fluoxetine lowered bacterial levels, increased anti-inflammatory molecules, and prevented life-threatening immune overreactions. Surprisingly, these benefits were independent of the drug’s known effects on serotonin.

This dual action—killing pathogens while preventing immune damage—could lead to new infection treatments. The findings highlight the potential for repurposing fluoxetine and similar SSRIs for infectious disease management.

Key Facts

Dual Protection: Fluoxetine both kills bacteria and prevents immune overreactions.

Sepsis Defense: Mice treated with fluoxetine had lower bacterial loads and survived infections.

Serotonin Independence: The drug’s immune benefits were unrelated to its effects on serotonin.

The full article can be found at the link ...

Ayres and Gallant say their next step is to explore fluoxetine dosing regimens appropriate for septic individuals. Credit: Neuroscience News