Methamphetamine induces DNA damage in specific regions of the female rat brain

[Chip (OP)]

source: https://www.ncbi.nlm.nih.gov/pubmed/25867833


Chipper says:

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How can such a PROFOUND drug experience such as opiate/opiod use or potent stimulants use NOT get into our RNA ?

It has to as it have fooled nature, Nuero-replasticized us and that winning combination must be marked as "top priority" for our Genome.

Doubt me ? please critique my logic and explain  why you reject my thought process ... (?)

a somewhat limiting but salient abstract on the damage (which I believe is a genetic transcription recoding process):

Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain.

In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine-rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine-rich brain regions that were tested.

Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.