Treatment of acute mania | Treatment of acute depression | Mania relapse - prevention | Depression relapse - prevention | |
Lithium | ++ | ++ | ++ | ++ |
Valproate | ++ | + | ++ | + |
Carbamazepine | + | 0 | + | 0 |
Lamotrigine | – | ++ | + | ++ |
Olanzapine | ++ | +(+1) | ++ | + |
Quetiapine | ++ | ++ | ++ | ++ |
Risperidone | ++ | – | ++2 | – |
Ziprasidone | ++ | – | ++ | – |
Aripiprazole | ++ | – | ++ | – |
Paliperidone | ++ | 0 | 0 | 0 |
Asenapine | + | 0 | + | 0 |
Antidepressants | – | – | – | – |
++ | good double-blind, placebo-controlled evidence |
+ | limited supportive double-blind, placebo-controlled evidence |
0 | no good double-blind, placebo-controlled evidence |
– | negative studies exist |
1 | including olanzapine-fluoxetine combination |
2 | risperidone long-acting injection (depot) |