dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse

This website has run out of funding so feel free to contribute if you can afford it (see footer)

Author Topic: The Role of 5-HT3 Receptors in Drug Abuse and Pharmacotherapy  (Read 8906 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6663
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:October 08, 2024, 06:17:38 AM
  • Deeply Confused Learner
  • Profession: IT Engineer
source: https://www.researchgate.net/publication/23763083_The_Role_of_5-HT3_Receptors_in_Drug_Abuse_and_as_a_Target_for_Pharmacotherapy

The Role of 5-HT3 Receptors in Drug Abuse and as a Target for Pharmacotherapy

Abstract:

Alcohol and drug abuse continue to be a major public health problem in the United States and other industrialized nations. Extensive preclinical research indicates the mesolimbicWiki dopamine (DA) pathway and associated regions mediate the rewarding and reinforcing effects of drugs of abuse and natural rewards, such as food and sex.

The serotonergic (5-HT) system, in concert with others neurotransmitter systems, plays a key role in modulating neuronal systems within the mesolimbic pathway. A substantial portion of this modulation is mediated by activity at the 5-HT3 receptor.

The 5-HT3 receptor is unique among the 5-HT receptors in that it directly gates an ion channel inducing rapid depolarization that, in turn, causes the release of neurotransmitters and/or peptides.

Preclinical findings indicate that antagonism of the 5-HT3 receptor in the ventral tegmental area, nucleus accumbens or amygdala reduces alcohol self-administration and/or alcohol-associated effects. Less is known about the effects of 5-HT3 receptor activity on the self-administration of other drugs of abuse or their associated effects.

Clinical findings parallel the preclinical findings such that antagonism of the 5-HT3 receptor reduces alcohol consumption and some of its subjective effects.

This review provides an overview of the structure, function, and pharmacology of 5-HT3 receptors, the role of these receptors in regulating DA neurotransmission in mesolimbic brain areas, and discusses data from animal and human studies implicating 5-HT3 receptors as targets for the development of new pharmacological agents to treat addictions.
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
Our Discord Server invitation link is https://discord.gg/jB2qmRrxyD

Tags:
 

Related Topics

  Subject / Started by Replies Last post
0 Replies
8509 Views
Last post August 28, 2015, 07:11:58 PM
by Chip
4 Replies
13812 Views
Last post November 17, 2015, 08:25:38 PM
by Chip
37 Replies
35019 Views
Last post January 25, 2018, 02:52:59 PM
by Chip
0 Replies
7279 Views
Last post February 02, 2017, 01:59:13 AM
by nick
0 Replies
7088 Views
Last post November 06, 2017, 08:43:21 PM
by Chip
1 Replies
8741 Views
Last post July 04, 2018, 03:59:45 AM
by Cronos Aegis
0 Replies
5741 Views
Last post May 27, 2019, 08:48:40 PM
by Chip
0 Replies
5772 Views
Last post June 01, 2019, 02:46:14 PM
by Chip
0 Replies
7925 Views
Last post October 22, 2019, 04:05:58 AM
by Chip
0 Replies
10153 Views
Last post September 08, 2023, 01:41:07 AM
by Chip


dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse





TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE


Founded December 2014
SimplePortal 2.3.6 © 2008-2014, SimplePortal