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Core Topics => Drugs => GABAergics => Topic started by: Jega on September 06, 2015, 12:23:42 AM
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So this is the popular girl in the club. The one who at moments picks who she goes home with rather than vice versa. Etizolam
(https://forum.drugs-and-users.org/proxy.php?request=http%3A%2F%2Fwww.drugfuture.com%2Fchemdata%2Fstructure%2FEtizolam.gif&hash=dde779aefce36168bcea80b38b14751c094739dc)
Etizolam is a thienodiazepine. What the hell does that mean. It means inside of a Benzene ring bonded to a Diazepine ring, this uses a a thiophene ring insted of the Benzene ring. What that means is it's unlike almost any other benzo in common circulation. It's also an oddball in that I can't think of any other benzo with 2 methyl groups attached to it. Etizolam acts as a full agonist at the benzodiazepine receptor GabaA(bzd) site. Make no mistake; this is absolutely a benzo!
1mg of Etizolam is equal to about 1mg of Alprazolam or 10 mg of Diazepam. Time to onset is about 30-60 minutes orally. Peak blood concentration is in about 2 hours on average but that's a stat I'd like to see more studies confirm. The whole curve effects is usually 6-8 hours in most people. In some countries Etizolam is a prescription drug, not only a RC, so this is a prescription drug even if it's not in your country.
It acts in many people as well as myself as an almost non sedating hypnotic. It does have a strong electro negative at the 2' position which is a common feature among hypnotics. The effects we associate with hypnotic benzodiazepine of sedation, retrograde amnesia, heavy anxiolytic effects, we can prescribe to Etizolam, but Etizolam wont necessarily "knock me out". This usually causes a dramatic story. I shared one of them before but I've kept most of them to myself at the risk of boring you all.
After months of experimenting with the "New" benzos, going back to this will be interesting. I only got it this morning since I'm in heavy WD and I broke and ordered what I knew would work from an old reliable source.
Feel free to share your own Etiz stories.
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Had a chance to sample a 3mg dose last night, with a bit of H (don't try that at home, kids. I'm a trained professional). More on the way soon next week. Will enjoy trying it again too. Last time I used any was Summer 2013.
Hey Jega you ever mess around with any quinazolines? Etaqualone was underwhelming. Short-acting and only good as a hypnotic, really. There's a couple other ones out IIRC, though. Worth a shot maybe.
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Had a chance to sample a 3mg dose last night, with a bit of H (don't try that at home, kids. I'm a trained professional). More on the way soon next week. Will enjoy trying it again too. Last time I used any was Summer 2013.
Hey Jega you ever mess around with any quinazolines? Etaqualone was underwhelming. Short-acting and only good as a hypnotic, really. There's a couple other ones out IIRC, though. Worth a shot maybe.
lol. You have no idea how much I'm waiting for a selection is high quality quaaludes analogs.I'll let the first one go through it's pases but i'll be ordering something eventually! But to answer your question No.
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I liked etiz a lot. Havent had any for a few months, but it was always good to me. A really big help in a time when I needed it badly, and couldnt get scripted benzos by any docs.
a shame, really, that id have to resort to the online-grey-legality rc world just to get some basic, sufficient relief
however my problem with etiz is the short half life.
clonazolam has been much, much better to me in that regard.
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my own Olanzapine is a thienobenzo, too.
it works well for anger and psychosis but has zero recreational value.
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my own Olanzapine is a thienobenzo, too.
it works well for anger and psychosis but has zero recreational value.
I have no idea Zyprexa was a thienobenzo! I dont consider Zyprexa (us trade name) as a benzo though. Does it poses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, and or amnestic properties? If not, it's not a benzo.
But for a chemistry geek you blew my mind there chipper!
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It's sedating, I guess. a lot.
Whilst I'm a chemistry failure, I do my research on my own meds.
thank you.
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It's sedating, I guess. a lot.
Whilst I'm a chemistry failure, I do my research on my own meds.
thank you.
Honestly chipper, simply structurally, it reminds me of a TCA than a Benzo. I know its a atypical antipsychotic (trazodone analog) but hay...you are right...technically it's a thienobenzo!
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however my problem with etiz is the short half life.
clonazolam has been much, much better to me in that regard.
I can absolutely see that.
Not to hijack your thread. I think these could help you. But i'd like someone to try:
Ketazolam, And Delorazepam.
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I liked etiz a lot. Havent had any for a few months, but it was always good to me. A really big help in a time when I needed it badly, and couldnt get scripted benzos by any docs.
a shame, really, that id have to resort to the online-grey-legality rc world just to get some basic, sufficient relief
however my problem with etiz is the short half life.
clonazolam has been much, much better to me in that regard.
After going though a half g this weekend you're absolutely right. It is too short. For all of it's positives you might get 3 hours 4 hours if you're lucky. If you dosed more you'ed hit that retrograde amnesia but i ended up with a new scar on my face level Etiz has.'
The last time I had Clonozolam I kept dosing till the retrograde amnesia killed me. I need to try that one again with more control.
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I got a good amount of Etizolam this weakened and i've noticed a new things. First off Etizolam has a halflife of 3-4 hours but it's metabolite must still be active: alpha-hydroxyetizolam(something so obscure it doesn't even have a google or wikipedia page). Loss of motor and speech control persist 6-8 hours after 1+ hour after dosing.
Benzos that have metabolites tend to have more then one. More research is needed. Someone needs a blood test 1-12 hours after dosing damnit!
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my own Olanzapine is a thienobenzo, too.
it works well for anger and psychosis but has zero recreational value.
I have no idea Zyprexa was a thienobenzo! I dont consider Zyprexa (us trade name) as a benzo though. Does it poses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, and or amnestic properties? If not, it's not a benzo.
But for a chemistry geek you blew my mind there chipper!
Thienobenzazepine, actually, in IUPAC, it's a thieno[2,3-b][1,5]benzodiazepine. Chemically distinct. That's a stretch comparing it to a trazodone analog, though, because trazodone is much more accurately characterized as a phenyl-piperazine compound. Because trazodone's active metabolite is m-chloro-phenyl-piperazine, hence it does not activate the same receptors as the "1-tricyclo"-piperazinyl molecule olanzapine does. Olanzapine acts as an antagonist at all of the receptors it interacts with, while trazodone behaves as a partial agonist of 5-HT1A, rendering it quite pharmacologically distinct from olanzapine, although, to be fair, it does share some crossover activity with olanzapine as antagonist at certain receptors in the CNS.
OK, pharm/chem/geek mode off... overandout.
TL/DR - thienobenzodiazepine is totally different from thienodiazepine.
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Etizolam has been a blessing for me. I mean, it's helped me keep my benzo habit, which ain't so great.. but if not for etiz I'd be copping xanax or clonopin off the streets for like 2-3 bucks a mg.
I only dose twice a day, once when I wake, once 3-4 before bedtime. I will go into WD if I have gone more than 12-16 hours without taking one. Once at work (about an hour into a 9-10 hour shift) I realized I had not taken my morning dose and had forgotten to bring my night time dose with me, that was a bad bad day.
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Etizolam has been a blessing for many people. Peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours:
The mean elimination half-life (t1/2) averaged 3.4 h
https://www.ncbi.nlm.nih.gov/pubmed/2065698
but alpha-hydroxyetizolam can have a half-life of up to 8.2 hours, far greater then the parent compound. So it many be the metabolites that are keeping you well rather then the parent compound, and they are very active.
this suggests that it may contribute significantly to the clinical effects of the parent compound
There is a lot about this compound we don't know. I'm not convinced we've identified all the metabolites yet, but if it helps you that's all that matter.
Wishing you the best Ryan
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I have no idea Zyprexa was a thienobenzo! I dont consider Zyprexa (us trade name) as a benzo though. Does it poses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, and or amnestic properties? If not, it's not a benzo.
But for a chemistry geek you blew my mind there chipper!
@Jega, i am wrong, Etiz. is actually a thienotriazolodiazepine.
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This discussion is all greek to me, except that I am the smallest bit familiar with greek. I'm scripted zyprexa but only take it occasionally & in a small amount at night. Too much or if not needed gives me lethargy & heavy limbs.
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Etizolam does not feel like Olanzapine (Zyprexa), Etizolam is less sedating, more of an amnesiac and more euphoric, with a short half-life.
IMO, 1 mg. Etizolam feels close to 5 mg. Diazepam and is a muscle relaxant.
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Hello i know this is old topic but want to know if anyone had a experience with Etizolam when having alcohol wd and what was your experience? does it helps? :))