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Core Topics => Drugs => GABAergics => Topic started by: Roxstar on June 02, 2015, 03:15:42 AM

Title: Benzodiazepines Equivalencies and Half-Lifes
Post by: Roxstar on June 02, 2015, 03:15:42 AM

Here's a small list of benzodiazepines with the half-life and equivalent dose to 10mg diazepam.  This list is not exact and is only a relative guideline.  This is not intended for dosing reference.  Consult with your physician before taking any medication. 


Benzodiazepines                   Oral dose (milligrams)                       Half-life (hours) {Active metabolite}

Alprazolam (Xanax)                           0.5                                            6-12

Bromazepam (Lexotan)                    6                                             10-20

Chlordiazepoxide (Librium)             25                                             5-30 {36-200}

Clonazepam (Klonopin, Rivotril)           0.5                                            18-50

Clorazepate (Tranxene)                   15                                             {36-200}

Diazepam (Valium)                           10                                             20-100 {36-200}

Estazolam (ProSom, Nuctalon)           1-2                                           10-24

Flunitrazepam (Rohypnol)                    1                                              18-26 {36-200}

Flurazepam (Dalmane)                    15                                            {40-250}

Halazepam (Paxipam)                    20                                            {30-100}

Ketazolam   (Anxon)                          15-30                                          30-100 {36-200}

Lorazepam (Ativan)                             1                                             10-20

Lormetazepam (Noctamid)                 1-2                                           10-12

Nitrazepam (Mogadon)                    10                                            15-38

Oxazepam (Serax)                              20                                            4-15

Prazepam (Centrax)                         10-20                                          {36-200}

Quazepam (Doral)                             20                                            25-100

Temazepam (Restoril)                     20                                            8-22

Triazolam (Halcion)                             0.5                                              2

Non-benzodiazepines

Zaleplon (Sonata)                              20                                                2

Zolpidem (Ambien, Stilnox)                20                                                2

Zopiclone (Zimovane)                        15                                                5-6

Eszopiclone (Lunesta)                         3                                                 6

Title: Re: Benzodiazepines Equivalencies and Half-Lifes
Post by: Narkotikon on June 03, 2015, 12:17:20 PM

Good list, Roxstar.  You seem to know a lot about benzos. 

Do you have any thoughts on Phenibut or w/d from it? 

Title: Re: Benzodiazepines Equivalencies and Half-Lifes
Post by: Roxstar on June 03, 2015, 02:25:03 PM

Hey, Nark.  How are ya man?  Good to have ya around again. 

As for phenibut, I don't have any experience with it.  I honestly never even heard of it until I was part of an online community.  From what I read though is that it's not as dangerous as benzos in regard to withdrawal.  It seems the research is all over the board so to speak...with varying opinions and contradicting findings. 

Benzos seem to be an agonist primarily at GABA (A) in the brain.  Phenibut acts primarily on GABA (B) with little to no action at GABA (A).  I think this is why there isn't such a dramatic withdrawal from phenibut (i.e. seizures)

I think it's interesting to note that, although the two drugs are very different, phenibut is accepted and used in Russia, whereas methadone is banned in Russia.

Title: Re: Benzodiazepines Equivalencies and Half-Lifes
Post by: sk8phaze on August 11, 2015, 06:02:17 AM

Also baclofen is just a modified version of phenibut. They say it works better and less side effects (withdrawal)