dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse

This website has run out of funding so feel free to contribute if you can afford it (see footer)

Author Topic: Why roadside drug (and even alcohol) tests are not always fair  (Read 3474 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6648
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Today at 05:29:51 AM
  • Deeply Confused Learner
  • Profession: IT Engineer
I have been researching tolerance and looking for any genetic indicators for possibly using genes to "tell" how much a person is tolerant to a particular drug.

As we all know, some of us function normally and in a totally sober fashion when we end up maintaining on our drugs(s) of choice.

For example, a person who drinks over 10 standard drinks a day will show no signs of intoxication if their blood alcohol limit is raised above the legal limit. So too for drug use and therein in lies the inadequacies and unfairness in such testing

An abstract can be found below on the Involvement of gene expression in drug tolerance and dependence can be found at https://www.ncbi.nlm.nih.gov/pubmed/7975924

The development of drug tolerance and dependence are thought to be associated with gene expression. Our studies showed that the binding activity of nuclear factors to several DNA sequences is altered by long-term treatment with methamphetamine, cocaine and morphine:

1) the binding activity of AP-1 increased markedly in the mouse brain after administration of methamphetamine and cocaine,

2) CRE-binding activity was decreased by chronic morphine treatment in the amygdala complex, cerebral cortex and hypothalamus of the mouse brain.

3) The binding activity of single-stranded CRE binding proteinsWiki was decreased by chronic morphine treatment in the mouse cerebellum.

This data suggest that the changes of DNA binding proteins can be involved in the development of drug tolerance
 and dependence.
« Last Edit: July 12, 2019, 07:50:19 AM by Chip »
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
Our Discord Server invitation link is https://discord.gg/jB2qmRrxyD

Tags:
 

Related Topics

  Subject / Started by Replies Last post
3 Replies
17870 Views
Last post February 10, 2015, 02:18:16 PM
by Chip
11 Replies
20861 Views
Last post September 04, 2015, 04:28:38 AM
by Jega
0 Replies
6649 Views
Last post August 28, 2015, 07:08:24 PM
by Chip
30 Replies
23496 Views
Last post October 20, 2015, 04:47:25 AM
by JonWrong
7 Replies
8955 Views
Last post March 15, 2016, 01:44:32 PM
by BTHvsECP
4 Replies
8493 Views
Last post November 17, 2015, 08:25:38 PM
by Chip
8 Replies
13422 Views
Last post March 09, 2019, 02:19:24 AM
by bignasty
11 Replies
11698 Views
Last post November 04, 2016, 03:00:06 AM
by 6-mam
3 Replies
6914 Views
Last post December 03, 2017, 05:21:14 PM
by Chip
2 Replies
6760 Views
Last post August 03, 2020, 07:13:59 AM
by oden123


dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse





TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE


Founded December 2014
SimplePortal 2.3.6 © 2008-2014, SimplePortal