dopetalk
Core Topics => Drugs => Hallucinogens/Psychedelics => Topic started by: Chip on July 06, 2019, 11:56:57 AM
-
Most people know that Benzodiazepine can effectively turn off a trip but do you know why ?
I did some research on this but failed to come up with the anwsers but i suspect that LSD causes hyper-connectivity between the sensory inputs and the benzos mitigate the amplitude of these signals therefore making the experience significantly more back to normal.
I could be wrong, of course. But I did learn to NEVER mix HaloperidolWiki with stimulants or with hallucinogens !
read about a discussion at https://drugs-forum.com/threads/effects-of-benzodiazepines-on-lsd.11157/
an article about LSD Toxicity Medication at https://emedicine.medscape.com/article/1011615-medication says:
If placing a patient who has used lysergic acid diethylamide (LSD) in a quiet environment with minimal stimuli is not effective, a benzodiazepine (lorazepam or diazepam) is the medication of choice, especially in patients with dysphoric reactions.
Benzodiazepines decrease central and peripheral sympathomimetic drug effects (EDIT: probably by acting on the Somatosensory CortexWiki.
As previously mentioned, neuroleptic medications, such as haloperidol (Haldol), may have adverse psychomimetic effects and thus are not indicated in LSD intoxication.
A discussion on Effects - Valium before an LSD trip is to be found at https://drugs-forum.com/threads/valium-before-an-lsd-trip.95824/
There is an article on Lysergic acid diethylamide antagonism by chlorpromazine, haloperidol, diazepam, and pentobarbital in the rabbit at https://www.sciencedirect.com/science/article/pii/0041008X77901958 but there only is this abstract:
The single and interactive iv effects of lysergic acid diethylamide (LSD, 50 μg/kg) given 20 min preceding or following chlorpromazine (CPZ, 1 and 2 mg/kg), haloperidol (HPD, 1 and 2 mg/kg), diazepam (Diaz, 1 and 2 mg/kg), or pentobarbital (Pb, 5 and 10 mg/kg) were assessed on electroencephalographic (EEG) cortical voltage output (CVO), behavior, and body temperature in unrestrained rabbits.
Depending on dose and administration order, each drug partially antagonized the decrease of CVO and (except for CPZ) the increase in standing duration and frozen-like postures caused by LSD.
LSD-induced hyperthermia was partially antagonized by CPZ and Diaz, not altered by Pb, and augmented by HPD.
Novel stereotypyWiki emerged from the interaction of LSD with HPD, Diaz, or Pb.
Additionally, three of five rabbits given LSD died shortly after HPD administration.
These data indicate that LSD is partially but not completely antagonized by these drugs, and the nature of the interaction with LSD depends on dose and order of LSD-drug administration.