dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse

This website has run out of funding so feel free to contribute if you can afford it (see footer)

Author Topic: Chronic cocaine use modifies gene expression  (Read 19145 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6648
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Yesterday at 05:53:23 PM
  • Deeply Confused Learner
  • Profession: IT Engineer
Chronic cocaine use modifies gene expression
« on: September 05, 2019, 10:39:09 AM »
source: https://neurosciencenews.com/cocaine-gene-expression-14850/

All drugs alter genes and is probably the underlying mechanism behind tolerance also.

Chronic cocaine use modifies gene expression

Chronic cocaine use alters the epigenetic profile of the FosB gene in the hippocampus. These alterations are required for cocaine-dependent gene expression and cocaine environment associations. Modification of hippocampal FosB results in a condition critical for cocaine-related learning.

Chronic cocaine use changes gene expression in the hippocampus, according to research in mice recently published in Journal of Neuroscience.

Chronic drug users learn to associate the drug-taking environment with the drug itself, reinforcing memories that contribute to addiction. These memories are thought to be created by changes in gene expression in the hippocampus and potentially involve the gene FosB, but the exact mechanism is unknown.

A.J. Robinson and colleagues at Michigan State University examined how cocaine exposure affected expression of the FosB gene in the hippocampus. Mice that were administered cocaine daily showed increased expression of FosB compared to mice that received saline.

Chronic cocaine use caused epigenetic modification of the gene, leading it to becoming more active.

Additionally, when the scientists blocked the changes made to FosB, the mice were unable to form associations between cocaine and the environment where they received it, implicating epigenetic regulation of the gene in drug memory formation.



Hippocampal neurons (green) expressing the FosB gene (red) after cocaine exposure

These results offer new insights in the molecular changes that take place in the hippocampus during chronic cocaine use. Further research in this area could lead to the development of addiction therapies.
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
Our Discord Server invitation link is https://discord.gg/jB2qmRrxyD

Offline Olinmon

  • Newbie
  • Join Date: Nov 2019
  • Location:
  • Posts: 1
  • Reputation Power: 2
  • Olinmon is new on the scene.
  • Last Login:November 08, 2019, 08:56:36 PM
Re: Chronic cocaine use modifies gene expression
« Reply #1 on: November 08, 2019, 08:56:23 PM »
What do they mean by chronic in this case?
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6648
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Yesterday at 05:53:23 PM
  • Deeply Confused Learner
  • Profession: IT Engineer
Re: Chronic cocaine use modifies gene expression
« Reply #2 on: November 09, 2019, 05:30:36 AM »
Daily use.

The study doesn't say how long it ran but i would guess for a few months.
friendly
0
funny
0
informative
0
agree
0
disagree
0
like
0
dislike
0
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
No reactions
Our Discord Server invitation link is https://discord.gg/jB2qmRrxyD

Tags:
 

Related Topics

  Subject / Started by Replies Last post
5 Replies
8599 Views
Last post May 02, 2019, 06:05:09 PM
by Chip
0 Replies
4850 Views
Last post May 22, 2018, 04:03:37 AM
by Chip
0 Replies
5528 Views
Last post May 22, 2018, 04:52:45 AM
by Chip
0 Replies
4865 Views
Last post June 02, 2018, 10:52:42 AM
by Chip
0 Replies
3990 Views
Last post June 02, 2018, 12:27:21 PM
by Chip
3 Replies
7015 Views
Last post March 25, 2019, 01:27:04 PM
by milky
0 Replies
4993 Views
Last post December 16, 2018, 07:04:31 PM
by Chip
0 Replies
4461 Views
Last post September 04, 2019, 08:30:05 AM
by Chip
0 Replies
5199 Views
Last post October 20, 2019, 06:05:55 AM
by Chip
0 Replies
3223 Views
Last post June 08, 2021, 01:11:30 AM
by Chip


dopetalk does not endorse any advertised product nor does it accept any liability for it's use or misuse





TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE


Founded December 2014
SimplePortal 2.3.6 © 2008-2014, SimplePortal