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Author Topic: GABA subunits A (there are 5) and B (there are 2) differences and drug examples  (Read 6346 times)

Offline Chip (OP)

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GABA subunits A (there are 5) and B (there are 2) differences and drug examples
« on: February 08, 2024, 10:09:01 AM »
GABA type A (GABAA) receptor is a ligand-gated chloride channel which mediates fast inhibitory signals through rapid postsynaptic membrane hyperpolarization whereas the metabotropic GABAB receptor produces slow and prolonged inhibitory signals via G proteins and second messengers (GPCRs).

As far as drugs go, Diazepam and Alprazolam are examples of agonists that bind to GABA A and do so quickly whilst Gabapentinoids like Baclofen or Phenibut bind to GABA B and may take hours to kick in yet GHB is also an agonist there but kicks in must faster.

« Last Edit: February 08, 2024, 12:28:55 PM by Chip »
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