Reversing or Protecting Against Methamphetamine's Neurotoxic's Effects

[Chip (OP)]

Some related studies and tools of interest etc.

N-acetylcysteine-amide improves tissue oxidative stress, DNA damage, and proteins disappearance in methamphetamine toxicity more efficiently than N-acetyl-L-cysteine:

https://www.sciencedirect.com/science/article/abs/pii/S2352007821000184#:~:text=Injection%20of%20NAC%20and%20NACA,than%20NAC%20in%20treated%20animals.

How reversible is Meth related brain damage ?

https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://commons.und.edu/cgi/viewcontent.cgi%3Farticle%3D1408%26context%3Dndlr&ved=2ahUKEwiPz_TI05uDAxVWQPUHHTptBIgQFnoECC0QAQ&usg=AOvVaw0Izx38l7MkFbYj00ZXaA31

NIDA Pursues Many Approaches to Reversing Methamphetamine’s Neurotoxic Effects:

https://www.ehd.org/health_meth_11.php

The effects of vitamin B12 on the brain damages caused by methamphetamine in mice:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960763/

Selegiline:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374985/#:~:text=Based%20on%20this%20finding%2C%20it,activation)(77%2C%2078).

MDMA oriented article should help with Meth too:

https://www.usersnews.com.au/home/2019/12/18/supplements-guide

Baicalein reverse the methamphetamin-induced striatal dopaminergic neurotoxicity in mice

[Chip (OP)]

Key Vitamins and Supplements for Meth Recovery:

https://www.harmonyridgerecovery.com/vitamins-supplements-meth-recovery/

One well informed person's complete stack of daily supplements:

**__AM__**
* **Synthroid** *(levothyroxine sodium)* 100mcg
* **Mydayis** *(mixed amphetamine salts, 3-bead ER)* 50mg
* **MethylPro® B Complex** *(thiamine mononitrate, riboflavin 5' phosphate, niacinamide, pyridoxine hydrochloride and pyridoxal 5' phosphate, L-5-methylfolate calcium, methylcobalamin, biotin, calcium D-pantothenate, choline bitartrate, inositol, para-aminobenzoic acid)*
* **NALT** *(N-acetyl-L-tyrosine)* 350mg
* **ALCAR** *(acetyl-L-carnitine)* 500mg
* **L-Citrulline** 1,300mg
* **TeaCrine®** *(theacrine)* 100mg
* **Cognizin®** *(citicoline)* 250mg
* **CoQH-CF™** *(ubiquinol)* 100mg
* **Magtein®** *(magnesium L-threonate)* 1,334mg / 96mg elemental magnesium
* **Cognance™** *(Bacopa monnieri extract, whole plant)* 100mg *(10% Ebelin lactone [1])*
* **AvailOm®** *(omega-3 PUFA / L-Lysine complex)* 1000mg *(245mg DHA / 205mg EPA FFA) [2]*
* **PrimaVie®** *(purified shilajit)* 250mg
* **Longvida® Curcumin** *(optimized Curcuma longa extract, rhizome)* 400mg *(23% curcuminoids)*
* **Tongkat Ali Extract** *(Eurycoma longifolia extract, root)* 100mg *(10% eurycomanone)*
* **Horny Goat Weed Extract** *(Epimedium brevicornum extract, leaf)* 500mg *(10% icariin)*
* **Tribulus Extract** *(Tribulus terrestris extract, fruit)* 500mg *(20% protodioscin)*

**__Noon__**
* **NALT** *(N-acetyl L-tyrosine)* 350mg
* **Cognizin®** *(citicoline)* 250mg

**__PM__**
* **Depakote ER** *(divalproex sodium, 24-hr ER)* 1500mg
* **Crestor** *(rosuvastatin calcium)* 5mg
* **Vitamin D3** *(cholecalciferol)* 125mcg Mon-Fri | 250mcg Sat-Sun
* **Xyzal** *(levocetirizine dihydrochloride)* 5mg
* **Truvada** *(emtricitabine-tenofovir disoproxil fumarate)* 200mg-300mg
* **Magtein®** *(magnesium L-threonate)* 667mg / 48mg elemental magnesium
* **Magnesium glycinate** *(magnesium bisglycinate chelate monohydrate)* 1,067mg / 133mg elemental magnesium
* **LiOr** *(lithium orotate)* 20mg
* **NACET 100mg + Cofactors** *(N-acetyl-L-cysteine ethyl ester, L-selenomethionine, Molybdenum, Glycine)*
* **Pregnenolone** *(micronized)* 5mg
* **Beta-ecdysterone** *(Cyanotis arachnoidea extract, root)* 500mg *(50% beta-ecdysterone/20-hydroxyecdysone)*
* **Licorice Extract** *(Glycyrrhiza glabra extract, root)* 25mg *(98% Isoliquiritigenin [3])*
* **Noble Kava Extract** *(Piper methysticum extract, root)* 1,000mg *(10% kavalactones [4])*

**__As-Needed__**
* **Klonopin** *(clonazepam)* Up to 1mg/d
* **Lunesta** *(eszopiclone)* 2mg qhs
* **Cialis** *(tadalafil)* 20mg/d

[Chip (OP)]

l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834329/