If you need any help or a chat then IM/PM or email me, Chip

Author Topic: Single Shot of Ketamine May Herald 'Last Call' for Problem Drinking  (Read 1811 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6335
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Today at 05:06:22 AM
  • Deeply Confused Learner
  • Profession: IT Engineer
source: https://www.medscape.com/viewarticle/922460

Single Shot of Ketamine May Herald 'Last Call' for Problem Drinking

December 11, 2019

An experimental treatment that includes a single infusion of ketamine may lead to long-term improvement in problem drinking, new research suggests.

In an study of 90 heavy drinkers, those who received a single dose of intravenous (IV) ketamine plus cognitive behavioral therapy (CBT) that focused on reactivating drinking-related "maladaptive reward memories" (MRMs) significantly curbed the urge to drink and reduced alcohol intake  compared with those who received the ketamine alone or a placebo infusion.

In addition, the combination group reduced their average weekly alcohol consumption by 50% over 9 months of follow-up.

MRMs can cause the brain's reward-learning system to produce an exaggerated desire to take a drug. However, the ketamine plus CBT intervention worked to "reboot" the brain, in order to relearn healthy associations. "This is a first demonstration of a very simple approach," lead investigator Ravi Das, PhD, associate professor, University College London (UCL) Clinical Psychopharmacology Unit, United Kingdom, told Medscape Medical News.

"We hope that with more research into optimizing the method, this could turn into a helpful treatment for excessive drinking, or potentially for other drug addictions," Ravi added in a statement.

The findings were published online November 26 in Nature Communications.

Hijacking the Brain

MRMs are "central to drug and alcohol addiction", the investigators note.

Drug abuse "hijacks the brain's in-built reward-learning system so that you end up associating environmental 'triggers' with the drug," Das said.

"Unfortunately, once these reward memories are established, it's very difficult to re-learn more healthy associations, but it's vital in order to prevent relapse," he added. "We were interested in the processes underlying why people react and the main thing seems to be these learned responses to their environment."

"It's a bit like Pavlov's dog," a famous research subject who learned to associate the reward of food with the ringing of a bell, which induced salivation, he said. 

"Humans have the same kind of automatic learning process. So we were looking at ways to break those associations, and one of the most promising methods is this process of memory reconsolidation," Das added.

In addition, because destabilized memories rely on an N-methyl D-aspartate receptor (NMDAR) mediated protein cascade to re-stabilize themselves, adjunctive ketamine, an NMDAR antagonist, was added to the protocol.

"The main reason we were interested in using ketamine is because we knew it blocks this receptor. And we thought we could use it as a tool to weaken alcohol memories," Das said.

Heavy Drinkers

Ninety individuals (61% men; mean age, 27.5 years) with harmful drinking behavior, but without a formal diagnosis of alcohol use disorder, were enrolled in the study. All had a score greater than 8 on the Alcohol Use Disorders Identification Test.

Participants consumed an average of 74 units of alcohol (8 g) per week, five times the recommended limit. Participants preferred beer, and so 74 units was the equivalent of 30 pints of beer per week.

In the study, all were given a glass of beer, told they could not drink it until they finished a task, and were then asked to rate the intensity of their urge to drink.

Participants also rated their anticipated pleasure after seeing images of beer and other alcoholic drinks. This process focused on retrieving reward memories associated with beer drinking.

Baseline drinking urges were determined on Day 1 when the participants were permitted to drink the beer. On Day 3, the beer was unexpectedly taken away in order to destabilize a retrieved reward memory.

"Typically the brain would then undergo an active process to re-stabilize and store the memory. However, ketamine prevents this memory re-storage process by blocking a receptor in the brain needed to re-stabilize memories," the researchers noted in the release.

Immediately after the beer was removed, one third of study participants received an IV infusion of ketamine hydrochloride, while another third received a saline placebo infusion. The remaining third received the ketamine infusion but without going through the memory retrieval procedure. All participants underwent blood draws before, and after, the infusions.

Long-Term Improvement

Results at the 10-day follow-up showed that compared with the other two groups, the ketamine plus memory retrieval group had significant reductions in "urge to drink" ratings (P ≤ .007).

They also showed pre-drink reductions in their anticipated enjoyment of beer (P < .001) and in actual enjoyment after drinking the beer (P = .004). They also experienced a reduction in weekly alcohol consumption (P < .001), and had a significant reduction in binges, defined as more than 6 drinks per weeks (P < .001). 

All three groups decreased their drinking behavior over the 9-month follow-up period. However, the ketamine plus memory retrieval group had greater initial improvement than the other groups, and a greater overall improvement over time.

Both ketamine groups significantly reduced their drinking volume at the 9-month assessment, but only the combination group lowered their total number of drinking days and bingeing behavior.

Finally, blood levels of ketamine predicted beneficial changes in drinking behaviors — but only after MRM reactivation. 

Overall, "we found that heavy drinkers experienced a long-term improvement after a very quick and simple experimental treatment," Das said.

"An advantage of our study, alongside the pronounced, long-term effect on drinking, is that it's based on a strong understanding of how the drug is working in the brain to achieve its effect," senior author Sunjeev Kamboj, also from the UCL Clinical Psychopharmacology Unit, said in the release.

Das admitted that he was somewhat surprised that the process worked.

"I've been doing research in this field for about 10 years and you get used to expecting not much because getting people to change their behavior around drug use is very difficult," he said.

So seeing their findings was a pleasant surprise, Das noted. However, he cautioned that this is still an experimental procedure and more research is needed before any recommendations can be made.

In addition to looking into whether they can replicate the findings in a large clinical trial, the investigators hope to assess whether other, more noninvasive drugs may be helpful and whether the treatment regimen is effective in conditions such as post-traumatic stress disorder.

"Promising Hypothesis"

Commenting on the study for Medscape Medical News, George Koob, PhD, director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), said the findings "open a promising hypothesis" that should be tested further.

"There are multiple aspects of treatment for alcohol use disorder, one of which is behavioral treatments," Koob said. If the results of this bear out in other studies, this particular intervention "could be a great add-on to the armamentarium," he said.

"Similarly, we're always looking for medications that will help. And both of those are woven into the fabric of this paper," Koob said.

However, he added that ketamine can be a major drug of abuse.

"Ketamine itself may not be the 'drug of drugs,' but the target that they are hypothesizing, working through the glutamatergic system, may indeed be a very good target," Koob said.

He noted that the behavioral part of the investigators' process has demonstrated efficacy in animal studies.

"So this is a very nice confirmation that you can trigger craving and, by manipulating that craving, decrease drinking in humans," he said.

Koob added that the combination of a behavioral therapy, of which there could be others, plus a drug "could be potentially powerful."

I do not condone or support any illegal activities. All information is for theoretical discussion and wonder.
All activities discussed are considered fictional and hypothetical. Information of all discussion has been derived from online research and in the spirit of personal Freedom.

Offline MoeMentim

  • Global Moderator
  • Sr. Member
  • ****
  • SA_Chat+
  • **
  • Join Date: Nov 2015
  • Location:
  • Posts: 735
  • Reputation Power: 20
  • MoeMentim is now quite familiar.MoeMentim is now quite familiar.
  • Last Login:September 02, 2020, 07:21:30 AM
  • Our Harm Reduction & Safe Using forum
Re: Single Shot of Ketamine May Herald 'Last Call' for Problem Drinking
« Reply #1 on: February 07, 2020, 02:47:15 AM »
Those of you who know me know i've been getting ketamine injections for treatment resistant depression/bipolar for about a year and a half now.  I'm now 5 1/2 months sober in long term treatment.  Ket didn't stop or help me cut down my drinking but it did help me start doing things that helped my depression/bipolar/alcohol related anxiety.  Mostly it helped me start doing basic life stuff (like exercising, cleaning the apartment, walking the dog, socializing) that in turn helped my depression.  until i came to rehab i wasn't doing anything specifically geared toward stopping drinking aside from the odd aa meeting after a particularly bad bender.  I'd say try (clean, medical, hopefully via a professional) ketamine, it definitely won't hurt anything. 


Related Topics

  Subject / Started by Replies Last post
9 Replies
Last post November 28, 2017, 01:07:02 AM
by dillydudeEL14
0 Replies
Last post March 06, 2018, 03:49:37 AM
by Chip
0 Replies
Last post May 02, 2018, 06:35:09 AM
by Chip
8 Replies
Last post July 27, 2018, 11:49:05 PM
by bignasty
0 Replies
Last post June 02, 2018, 10:52:42 AM
by Chip
0 Replies
Last post June 24, 2018, 03:35:07 AM
by Chip
0 Replies
Last post May 10, 2019, 08:24:58 PM
by Chip
0 Replies
Last post July 04, 2019, 10:22:14 PM
by Chip
0 Replies
Last post November 28, 2019, 08:08:47 AM
by Chip
0 Replies
Last post January 04, 2020, 03:09:01 AM
by Chip


In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


Founded December 2014
SimplePortal 2.3.6 © 2008-2014, SimplePortal