Author Topic: Pysychedelic Trip Effect Mitigation  (Read 106 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6108
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Yesterday at 04:32:32 PM
  • Deeply Confused Learner
Pysychedelic Trip Effect Mitigation
« on: July 06, 2019, 11:56:57 AM »
Most people know that Benzodiazepine can effectively turn off a trip but do you know why ?

I did some research on this but failed to come up with the anwsers but i suspect that LSD causes hyper-connectivity between the sensory inputs and the benzos mitigate the amplitude of these signals therefore making the experience significantly more back to normal.

I could be wrong, of course. But I did learn to NEVER mix HaloperidolWiki with stimulants or with hallucinogens !

read about a discussion at https://drugs-forum.com/threads/effects-of-benzodiazepines-on-lsd.11157/

an article about LSD Toxicity Medication at https://emedicine.medscape.com/article/1011615-medication says:

If placing a patient who has used lysergic acid diethylamide (LSD) in a quiet environment with minimal stimuli is not effective, a benzodiazepine (lorazepam or diazepam) is the medication of choice, especially in patients with dysphoric reactions.

Benzodiazepines decrease central and peripheral sympathomimetic drug effects (EDIT: probably by acting on the Somatosensory CortexWiki.

As previously mentioned, neuroleptic medications, such as haloperidol (Haldol), may have adverse psychomimetic effects and thus are not indicated in LSD intoxication.

A discussion on Effects - Valium before an LSD trip is to be found at https://drugs-forum.com/threads/valium-before-an-lsd-trip.95824/

There is an article on Lysergic acid diethylamide antagonism by chlorpromazine, haloperidol, diazepam, and pentobarbital in the rabbit at https://www.sciencedirect.com/science/article/pii/0041008X77901958 but there only is this abstract:

The single and interactive iv effects of lysergic acid diethylamide (LSD, 50 μg/kg) given 20 min preceding or following chlorpromazine (CPZ, 1 and 2 mg/kg), haloperidol (HPD, 1 and 2 mg/kg), diazepam (Diaz, 1 and 2 mg/kg), or pentobarbital (Pb, 5 and 10 mg/kg) were assessed on electroencephalographic (EEG) cortical voltage output (CVO), behavior, and body temperature in unrestrained rabbits.

Depending on dose and administration order, each drug partially antagonized the decrease of CVO and (except for CPZ) the increase in standing duration and frozen-like postures caused by LSD.

LSD-induced hyperthermia was partially antagonized by CPZ and Diaz, not altered by Pb, and augmented by HPD.

Novel stereotypyWiki emerged from the interaction of LSD with HPD, Diaz, or Pb.

Additionally, three of five rabbits given LSD died shortly after HPD administration.

These data indicate that LSD is partially but not completely antagonized by these drugs, and the nature of the interaction with LSD depends on dose and order of LSD-drug administration.
« Last Edit: July 07, 2019, 09:56:58 AM by Chip »
Over 90% of all computer problems can be traced back to the interface between the keyboard and the chair !

Tags:
 

Related Topics

  Subject / Started by Replies Last post
3 Replies
1293 Views
Last post August 03, 2015, 01:49:08 PM
by Thoms
2 Replies
1919 Views
Last post June 15, 2016, 03:56:47 PM
by Opi-ette
0 Replies
1474 Views
Last post August 16, 2016, 12:35:42 PM
by Chip
1 Replies
1791 Views
Last post September 28, 2016, 07:55:46 PM
by MoeMentim
0 Replies
948 Views
Last post March 06, 2018, 03:49:37 AM
by Chip
5 Replies
2045 Views
Last post May 02, 2019, 06:05:09 PM
by Chip
4 Replies
1069 Views
Last post September 26, 2018, 02:32:17 AM
by Chip
0 Replies
113 Views
Last post June 30, 2019, 09:22:34 AM
by Chip
0 Replies
122 Views
Last post July 02, 2019, 04:06:41 PM
by Chip




TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE



Founded December 2014