Author Topic: The opiate antagonist naloxone does not wake us from the delta sleep phase  (Read 141 times)

Offline Chip (OP)

  • Server Admin
  • Hero Member
  • *****
  • Administrator
  • *****
  • Join Date: Dec 2014
  • Location: Australia
  • Posts: 6012
  • Reputation Power: 0
  • Chip has hidden their reputation power
  • Gender: Male
  • Last Login:Today at 05:44:03 AM
  • Deeply Confused Learner
source: https://www.ncbi.nlm.nih.gov/m/pubmed/3097709/

Abstract:

To see if the opiate receptor/endorphin system plays a part in the regulation of natural sleep in humans the effects of the opiate antagonist naloxone on delta sleep were examined. The sleep behaviour of each of six healthy male volunteers aged 20-32 years was monitored by continuous recordings of EEG, EOG, EMG, heart rate and respiratory rate for 3 nights. The sleep stages were evaluated according to Rechtschaffen and Kales. Naloxone (0.03 mg/kg body wt.) or saline as placebo was administered intravenously in a double-blind randomized order during the spontaneously occurring delta sleep, the effects being observed on sleep behaviour and recorded variables. Naloxone never elicited arousal, either in the EEG or in the subjects' behaviour. The only effect noted was an increase in the mean latency of the first REM sleep stage. Naloxone does not arouse humans from natural delta sleep. It seems unlikely therefore, that endorphins play a role in the regulation of delta sleep in humans unless there are opiate receptor subtypes involved for which naloxone has a low affinity in man.
Over 90% of all computer problems can be traced back to the interface between the keyboard and the chair !

Tags:
 

Related Topics

  Subject / Started by Replies Last post
11 Replies
5642 Views
Last post June 23, 2015, 06:51:47 AM
by Chip
0 Replies
1790 Views
Last post June 30, 2015, 07:29:24 AM
by Chip
3 Replies
2416 Views
Last post September 08, 2016, 09:35:07 AM
by Chip
0 Replies
1351 Views
Last post October 17, 2016, 03:26:42 PM
by Chip
13 Replies
1804 Views
Last post November 06, 2016, 04:31:37 AM
by Chip
13 Replies
3330 Views
Last post December 15, 2016, 04:00:52 PM
by Chip
5 Replies
928 Views
Last post October 25, 2018, 07:22:59 AM
by MoeMentim
1 Replies
547 Views
Last post March 05, 2019, 10:19:20 PM
by Chip
0 Replies
205 Views
Last post May 02, 2019, 12:11:09 PM
by Chip
0 Replies
100 Views
Last post June 12, 2019, 03:22:48 PM
by Chip




TERMS AND CONDITIONS

In no event will d&u or any person involved in creating, producing, or distributing site information be liable for any direct, indirect, incidental, punitive, special or consequential damages arising out of the use of or inability to use d&u. You agree to indemnify and hold harmless d&u, its domain founders, sponsors, maintainers, server administrators, volunteers and contributors from and against all liability, claims, damages, costs and expenses, including legal fees, that arise directly or indirectly from the use of any part of the d&u site.


TO USE THIS WEBSITE YOU MUST AGREE TO THE TERMS AND CONDITIONS ABOVE



Founded December 2014