Author Topic: Methamphetamine induces DNA damage in specific regions of the female rat brain.  (Read 368 times)

Offline Chip (OP)

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shamelessly ripped straight from PubMed (is that like club med ?)

Methamphetamine is neurotixic and thus increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain.

They examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions.

Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine-rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine-rich brain regions that were tested.

Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.
well, that's me fucked and glad to not have wanted kids
Over 90% of all computer problems can be traced back to the interface between the keyboard and the chair !

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